Diagnostic value of copeptin combined with hypersensitive cardiac troponin T detection in early acute myocardial infarction: A protocol of randomized double-blind diagnostic trial

Background:The sensitivity and specificity of the routine detection of acute myocardial infarction (AMI) in early diagnosis are not high, which can not meet the clinical needs. Copeptin combined with hypersensitive cardiac troponin T (hs-cTnT) is a new detection scheme, and its value in the early diagnosis of acute myocardial infarction is still unclear. Accordingly, the aim of this study is to evaluate the diagnostic value of copeptin combined with hypersensitive troponin T detection in early acute myocardial infarction.Methods:This is a prospective, randomized; double-blind diagnostic trial to investigate the diagnostic value of copeptin combined with hypersensitive troponin T detection in early acute myocardial infarction. Approved by the clinical research ethics of our hospital. Patients were randomly divided into one of 2 test protocols: (A) copeptin combined with hs-cTnT group and (B) cardiac troponin I (cTnI) group. Patients, doctors, nurses, inspectors, and data-gathering assistants were blinded to group allocation. We will focus on the sensitivity comparison of the 2 detection methods at different time periods and the sensitivity and specificity comparison of the two detection methods. Data were analyzed using the statistical software package SPSS version 25.0 (Chicago, IL).Discussion:The purpose of this study is to evaluate the diagnostic value of copeptin combined with hypersensitive cardiac troponin T detection in early acute myocardial infarction. The results of this study will establish clinical evidence for the detection of high sensitivity cardiac troponin T in the early diagnosis of acute myocardial infarction.Ethics and dissemination:Private information from individuals will not be published. This systematic review also does not involve endangering participant rights. Ethical approval was not required. The results may be published in a peer-reviewed journal or disseminated at relevant conferences.OSF Registration number:DOI 10.17605/OSF.IO/6TE5Z.     

hs-cTnT与心力衰竭分期及预后的相关性研究

目的探讨hs-cTnT与心力衰竭分期及预后相关性情况。方法分析我院2013年1月1日至2014年9月31日收治的心力衰竭患者216例临床资料,依据美国AHA/ACCD的成人慢性心力衰竭分期(A、B、C、D期)相对应分成4组,A组51例,B组55例,C组60例,D组50例。结果四组心力衰竭患者治疗后hs-cTnT及NT-proBNP水平均较各组治疗前明显降低,四组心力衰竭患者分期和治疗后hs-cTnT及NT-proBNP水平呈现明显正相关性,C组、D组心力衰竭患者不良事件发生率均优于A组、B组,P<0.05,差异均有统计学意义。结论 hs-cTnT水平和心力衰竭的发生发展关系密切,可对心力衰竭患者尽早干预及病情预后评估提供依据。     

芪苈强心胶囊对慢性心力衰竭患者血浆BNP及hs-cTnT的影响

目的:探讨芪苈强心胶囊对慢性心力衰竭患者血浆脑钠肽(BNP)及肌钙蛋白(hs-c Tn T)的影响。方法:选取2015年3月至2015年11月在鄂东医疗集团黄石市中心医院接受的慢性心力衰竭的60例患者,按随机数表法随机分为对照组和观察组,每组30例。观察组采用在常规方式前提下加服芪苈强心胶囊进用常规行治疗;对照组采用常规方式进行治疗。对比分析2组患者在治疗前后血浆BNP、hs-c Tn T、hs-CRP、IL-1、IL-6、TNF-α水平、6 min的步行试验距离及心脏相关彩超指标以及临床总有效率。结果:2组患者与治疗前比较血浆BNP及hs-c Tn T水平均有所下降,但观察组明显优于对照组,差异有统计学意义(P0.05);2组患者与治疗前比较,在接受治疗之后6 min的步行试验距离均有所增加,但观察组明显高于对照组且相关彩超指标明显优于优于对照组,差异有统计学意义(P0.05);2组患者与治疗前比较,接受治疗之后hs-CRP、IL-1、IL-6及TNF-α水平均有所下降,但观察组明显低于对照组,差异有统计学意义(P0.05);观察组患者总有效率(93.33%)明显高于对照组(76.67%),2组数据对比,差异有统计学意义(P0.05)。结论:芪苈强心胶囊可以有效地使患者心功能得到改善,能够使患者的血浆BNP及hs-c Tn T水平显著降低,其有助于慢性心力衰竭进行治疗,值得在临床上推广及应用。     

社区老年人高密度脂蛋白胆固醇与肾功能的关系研究

目的高密度脂蛋白胆固醇(HDL-C)对心血管系统有保护作用,低水平的HDL-C是独立于低密度脂蛋白胆固醇以外的心血管系统的危险因素。设计本研究的目的是调查HDL-C和肾功能在社区老年人群中的关系。方法调查研究北京石景山区某社区60岁以上常住人口,其中885名社区老年人的估算的肾小球滤过率(eGFR)水平,对其与HDL-C水平之间的关系进行单因素分析以及多元线性回归分析。结果 885例研究人群中男性367名(41.5%)和女性518名(58.5%),年龄范围为60~96岁,平均年龄为(69.2±6.3)岁。简单相关分析的结果表明,HDL-C与eGFR水平呈正相关关系(r=0.08,P=0.01)。在校正混杂因素后,社区老年人群的HDL-C水平独立地与e GFR水平相关。此外,总胆固醇、甘油三酯、低密度脂蛋白胆固醇、尿酸和同型半胱氨酸水平分别独立地与eGFR水平相关。结论在社区老年人群中发现HDL-C水平与肾功能变化是独立相关的。