Determinantion and evaluation of antisperm antibodies and seminal immunosuppressive material in recurrent aborting couples

Circulating antisperm antibodies (AsAb) and immunosuppressive material in seminal plasma (SPIM)were determined by solid-phase enzyme staining assay and anticomplement test respectively in 686 patients with abortion (including 285 couples) . 241 fertile couple served as control. It's found that the positive rate of AsAb in infertile patients was significantly higher than that in fertile control,being 36.6% vs 3.3% (P<0.001). AsAb was even more offen detected in recurrent aborting patients. Male patients whose spouses aborted 2-6 fetuses had significantly less SPIM than control, sperm count and sperm motility were also significantly decreased. But the incidence of pyospermia was significantly greater than that in control. It is concluded that AsAb and SPIM have played an important role in the development of recurrent abortions.     

Recurrent pregnancy loss due to familial and non-familial habitual molar pregnancy.

OBJECTIVES: To present a series of women with recurrent molar pregnancies, including rare familial cases, and discuss etiology and treatment options. METHODS: We performed a detailed clinical evaluation and pedigree analysis of five Egyptian women with recurrent pregnancy loss due to molar pregnancy. RESULTS: The women had a history of four to nine consecutive hydatidiform moles but of no viable pregnancies. Two of the women had molar pregnancies with different husbands who themselves had viable offspring from previous wives; and three of them, who belonged to a family with extensive intermarriage, had a pedigree consistent with an autosomal recessive maternal-effect mutation. CONCLUSIONS: Recurrent pregnancy loss due to habitual molar pregnancy is uncommon and familial cases are extremely rare. The etiology of this disorder is not well understood but likely results from a maternal-effect mutation. Management options are limited, especially for couples who desire to have their own genetic offspring.     

主动免疫恢复T辅助细胞平衡治疗习惯性流产

目的:寻求安全、有效地治疗不明原因习惯性流产(UHA)的方法,并探讨主动免疫治疗前后的细胞因子的免疫功能变化及T辅助细胞的平衡状态。方法:①对35例UHA患者采用丈夫肘静脉血20 m l分离淋巴细胞行主动免疫治疗(妊娠前治疗两次,妊娠后治疗两次);②采用酶联免疫吸附方法对68例UHA患者及30例正常妇女外周血IL-2、IL-4、IL-10、IFN进行检测;③对29例主动免疫后妊娠成功者治疗前后的IL-2、IL-10、Th1/Th2进行检测。结果:①主动免疫组33例妊娠,妊娠成功并分娩29例,妊娠成功率87.88%(29/33),未经主动免疫治疗的对照组妊娠成功率26.67%(8/30),两组相比差异有显著性(P<0.010);②68例UHA患者较正常妇女外周血中IL-2明显升高(P<0.01),IL-10降低(P<0.05),Th1/Th2比值增高(P<0.05);③29例UHA患者主动免疫治疗后妊娠成功者IL-10显著上升(P<0.1),Th1/Th2比值下降(P<0.05)。结论:UHA患者Th1、Th2平衡异常,主动免疫治疗可诱导Th1向Th2转移,恢复Th1、Th2之间的平衡,可用于UHA的治疗。     

Body composition,work capacity,and work efficiency of active and inactive young men

On 46 healthy young men, of whom 18 took part in strenuous sport at least once a week, height, weight, total body fat (as % of body mass) and lean body mass (LBM) were determined. The subjects performed submaximal exercise on a bicycle ergometer and climbing on an upwardly inclined treadmill at work loads of 60, 110, and 140 watts. Oxygen consumption ( ), respiratory quotient (RQ), energy expenditure (), and heart rate (f _H) were measured at rest and at each work load, and maximum oxygen intake ( max) and physical work capacity (PWC₁₅₀, PWC₁₇₀) were calculated.Anthropometric parameters did not differ significantly between sportsmen and sedentary subjects. max, PWC₁₅₀, and PWC₁₇₀ had higher correlations with LBM than with the other anthropometric parameters. max expressed in terms of LBM (ml/kg LBM/min) was the parameter which showed the clearest distinction between sportsmen and sedentary individuals. The sportsmen had higher max on the treadmill test than on the bicycle ergometer. PWC₁₅₀ and PWC₁₇₀ were higher on the bicycle than on the treadmill and had high correlations with max. Work efficiency was of the same order in both groups and showed negative correlation with the degree of obesity on the bicycle ergometer and positive correlation on the treadmill.     

Anti-idiotypic IgM antibodies to anti-HLA class I antibodies in habitual abortion.

In order to investigate the role of the idiotypic network in miscarriages, sera from 28 habitually aborting women undergoing paternal leukocyte immunization were studied for the presence of HLA antibodies and related anti-idiotypes. Sixty-eight percent of sera from preimmunized patients which did not contain anti-lymphocyte antibodies inhibited the activity of antibodies to the HLA class I antigens expressed by the spouse. This inhibitory activity could be assigned to IgM antibodies, which cross-inhibit antibodies of similar specificity. This suggests that they are anti-idiotypes for the binding site of HLA antibodies. Immune sera of successfully treated patients exhibited both cytotoxic IgG anti-HLA antibodies and inhibitory IgM anti-idiotypic antibodies. A possible role for an intact idiotypic network in maintaining pregnancy is suggested.     

健康教育对习惯性流产患者社会支持和抑郁的影响

目的:探讨健康教育对于习惯性流产患者社会支持和抑郁的影响.方法:选择2010年6月～ 2011年6月习惯性流产患者140例,随机分为实验组(健康教育组)70例和对照组70例,对照组实施常规护理,而实验组在对照组的基础上进行健康教育的干预,用社会支持量表(SSQ)和汉密尔顿抑郁量表对两组患者在干预前后进行测量,比较评分结果.结果:实验组社会支持总分与对照组相比明显提高,抑郁总分较对照组明显下降.结论:在临床护理中应注重与患者建立良好的护患关系；对患者进行健康教育对习惯性流产患者抑郁的缓解及社会支持水平的提高是有效的.     

寿胎丸治疗习惯性流产23例

目的：探讨寿胎丸对习惯性流产的治疗效果,为习惯性流产治疗提供安全有效方法。方法47例习惯性流产患者,随机分为对照组24例和研究组23例。对照组给予临床常规治疗,研究组在常规治疗的基础上给予寿胎丸治疗,观察对比两组患者治疗效果。结果研究组患者治愈9例,有效12例,总有效率91.30%,对照组患者治愈5例,有效9例,总有效率58.33%,两组比较差异有统计学意义(P<0.05)。结论寿胎丸能够有效降低习惯性流产发生率,治疗安全可靠,临床可积极推广应用。     

Relationship between habitual physical activity,motor capacity,and capability in children with cerebral palsy aged 4–5 years across all functional abilities

Background

Children with cerebral palsy (CP) have lower habitual physical activity (HPA) than their typically developing peers. There are limited studies of HPA in young children with CP under the age of 5 years.