Case Report: Transient Stress Hyperglycemia in the Patient With ST-Elevation Myocardial Infarction

Transient stress hyperglycemia in the setting of acute myocardial infarction is a frequent phenomenon. Its transient nature should not dissuade the clinician from management of elevated blood glucose in a patient after an ST-elevation myocardial infarction. This case presents an adult patient after an ST-elevation myocardial infarction with transient stress hyperglycemia and the evidence used to identify optimal pharmacologic management and secondary prevention.     

儿童肥胖症的相关影响因素与控制对策分析及其对糖尿病发病情况的影响

目的 分析儿童肥胖症的相关影响因素与控制对策分析及其对糖尿病发病情况的影响,为制定针对儿童肥胖症的防控措施提供理论依据。方法 将2012年5月-2018年1月期间于沈阳市第五人民医院儿科进行体检的836名儿童作为研究对象,统计本组研究对象中肥胖症发生率,并调查所有研究对象性别、年龄、学校性质、生活习惯等因素与肥胖症发生率的相关性。将出现肥胖症的患儿作为观察组,将正常儿童作为对照组,对比两组对象空腹血糖、餐后2 h血糖(2 hPBG),空腹血糖受损(IFG)、葡萄糖耐量异常(IGT)以及糖尿病发生率的差异。结果 836名儿童中,89名存在肥胖症,231名儿童体重超重,516名儿童BMI正常,肥胖症发生率为10.65%;多因素Logistic回归分析结果显示,男性(OR＝6.415,95%CI:2.714~12.684,P=0.027)、年龄>10岁(OR＝9.328,95%CI:2.413~10.152,P=0.003)、居住地在城市(OR＝6.413,95%CI:2.748~8.503,P=0.015)、早餐地点在家里(OR＝6.349,95%CI:2.692~8.419,P=0.009)、周末活动时间<1 h(OR＝14.928,95%CI:4.210~15.384,P<0.001)均是儿童肥胖症的危险因素;观察组FPG及2 hPBG表达水平均显著高于对照组(P<0.05);观察组IFG、IGT及糖尿病发生率均显著高于对照组(P<0.05)。结论 儿童肥胖症的发生与外界及自身多项因素有密切联系,还可能诱发糖尿病等并发症,临床中应针对诱导儿童肥胖症产生的具体因素制定相应控制对策,改善肥胖患儿生活质量,使其健康成长。     

Human metabolism: pathways and clinical aspects

Metabolism describes the series of chemical reactions that are concerned with the provision of energy to biological systems. They may be divided into reactions involved in energy yield (catabolism: demand exceeds supply), and energy storage (anabolism: supply exceeds demand). Regulation of these pathways is critical for homeostasis, and derangements in metabolism are seen in a wide variety of pathological processes. Understanding metabolism is key to the treatment of many diseases, notably diabetes, as well as underpinning clinical nutritional support.     

Fundamentals about onset and progressive disease character of type 2 diabetes mellitus

ResearchGate is a world wide web for scientists and researchers to share papers, ask and answer questions, and find collaborators. As one of the more than 15 million members, the author uploads research output and reads and responds to some of the questions raised, which are related to type 2 diabetes. In that way, he noticed a serious gap of knowledge of this disease among medical professionals over recent decades. The main aim of the current study is to remedy this situation through providing a comprehensive review on recent developments in biochemistry and molecular biology, which can be helpful for the scientific understanding of the molecular nature of type 2 diabetes. To fill up the shortcomings in the curricula of medical education, and to familiarize the medical community with a new concept of the onset of type 2 diabetes, items are discussed like: Insulin resistance, glucose effectiveness, insulin sensitivity, cell membranes, membrane flexibility, unsaturation index (UI; number of carbon-carbon double bonds per 100 acyl chains of membrane phospholipids), slow-down principle, effects of temperature acclimation on phospholipid membrane composition, free fatty acids, energy transport, onset of type 2 diabetes, metformin, and exercise. Based on the reviewed data, a new model is presented with proposed steps in the development of type 2 diabetes, a disease arising as a result of a hypothetical hereditary anomaly, which causes hyperthermia in and around the mitochondria. Hyperthermia is counterbalanced by the slow-down principle, which lowers the amount of carbon-carbon double bonds of membrane phospholipid acyl chains. The accompanying reduction in the UI lowers membrane flexibility, promotes a redistribution of the lateral pressure in cell membranes, and thereby reduces the glucose transporter protein pore diameter of the transmembrane glucose transport channel of all Class I GLUT proteins. These events will set up a reduction in transmembrane glucose transport. So, a new blood glucose regulation system, effective in type 2 diabetes and its prediabetic phase, is based on variations in the acyl composition of phospholipids and operates independent of changes in insulin and glucose concentration. UI assessment is currently arising as a promising analytical technology for a membrane flexibility analysis. An increase in mitochondrial heat production plays a pivotal role in the existence of this regulation system.