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目的:观察HD02对慢性前脑缺血大鼠神经干细胞增殖分化的变化。方法:结扎双侧颈总动脉制备慢性前脑缺血大鼠模型,采用免疫单标和双标方法检测成体大鼠神经干细胞及分化的功能细胞。给予模型大鼠HD02水煎剂灌胃,分别于造模后15,30d观察神经干细胞增殖分化的变化。结果:与正常对照组相比,慢性前脑缺血大鼠大脑皮质、室周区、海马BrdU阳性细胞数和BrdU+NF200,BrdU+NeuroD,BrdU+GFAP免疫荧光双标细胞数于造模后15d明显增多(P<0.01),但造模后30dBrdU阳性细胞数和BrdU+NF200,BrdU+NeuroD,BrdU+GFAP免疫荧光双标细胞数与正常对照组相比差异无显著性意义(P>0.05);造模后30d,HD02组BrdU阳性细胞数和BrdU+NF200,BrdU+NeuroD,BrdU+GFAP免疫荧光双标细胞数较慢性前脑缺血组明显增多(P<0.01)。结论:HD02可显著增加慢性前脑缺血大鼠神经干细胞增殖分化能力 相似文献
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Basic evaluation of Pentra MS CRP,a new automated hematology analyzer for rapid 5‐part WBC differential and CRP using a small volume of whole blood
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Portakal O Tavil B Kuşkonmaz B Aytaç S Hasçelik G 《Journal of clinical laboratory analysis》2011,25(2):71-75
This study was aimed to evaluate the analytical performance of an automated image analysis system (a pilot model of Diff Master? Octavia) for the preclassification of leucocytes in children with hematological disease. Manual microscopy performed by pediatric hematologists was used as the reference method. Five mature cell class and blasts were evaluated. Diff Master Octavia correctly preclassified 87.4% of all leucocytes with a high reproducibility. The overall accuracy was found to be 93.0%. Clinical sensitivity was 97.7% and specificity was 76.0%. The average time per slide for Diff Master? Octavia was 2.3 min lower than that of manual method. Our results indicated that the Diff Master? Octavia can detect and preclassify leucocytes accurately; therefore, it can be used as an efficient and fast method in pediatric hematology routine. J. Clin. Lab. Anal. 25:71–75, 2011. © 2011 Wiley‐Liss, Inc. 相似文献
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多发性硬化(multiple sclerosis,MS)是一种中枢神经系统炎性脱髓鞘疾病,多发生于青壮年,是成人神经性致残的主要原因。传统治疗仅能延长疾病的缓解期,并不能彻底治愈。诱导性多能干细胞(induced pluripotent stem cells,i PSCs)具有干细胞的分化全能性,在MS细胞替代疗法中具有广阔的应用前景;而体细胞转分化技术相较于传统的i PSCs分化成少突胶质细胞谱系,缩短了时间窗,为MS治疗提供了一条新思路。随着获取神经干细胞和少突胶质细胞效率和质量的提高,未来的MS细胞治疗将有望取得重大的突破。 相似文献
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本文通过对《伤寒论》中部分条文的分析,认为张仲景辨证论治的思路有以下的特点:①同病须审寒热虚实而异治;②病证可因体质禀赋而转归;③详辨病位病性而予鉴别;④治随证变凸显辨证原则;这些给后世医家以很大的启发,对中医临证思维有着极大的指导意义。 相似文献
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自噬在体内对于维持血管正常功能和结构发挥至关重要的作用。当受到应激刺激时,自噬水平增加,进
一步促进细胞存活、表型转化及减轻钙化,从而避免增殖性血管疾病的发生,对血管平滑肌细胞起保护作用。相
反,平滑肌自噬水平降低可促使细胞衰老,导致血管舒缩功能异常和结构改变,参与血管老化的进展。然而,自噬
过度激活会损伤平滑肌细胞内正常的蛋白质和重要细胞器,甚至引发自噬性细胞死亡,加速血管疾病的进程。因
此,充分利用自噬有利的一面,精确调控自噬或将成为治疗血管疾病的一种崭新方式。 相似文献
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Poor cell block adequacy rate for molecular testing improved with the addition of Diff‐Quik–stained smears: Need for better cell block processing
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