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排序方式: 共有549条查询结果,搜索用时 15 毫秒
1.
Carlos Robles-Medranda Manuel Valero Miguel Puga-Tejada Roberto Oleas Jorge Baquerizo-Burgos Miguel Soria-Alc var Haydee Alvarado-Escobar Hannah Pitanga-Lukashok 《World journal of gastrointestinal endoscopy》2020,12(1):23-32
BACKGROUND Accurate detection of gastric infection by Helicobacter pylori(H.pylori) and premalignant lesions are important for effective provision of treatment,preventing the development of gastric neoplasia.Optical enhancement systems with optical magnification improved the identification of mucosal superficial and vascular patterns in patients with dyspepsia.AIM To evaluate an optical enhancement system with high-definition magnification,for diagnosis of normal gastric mucosa,H.pylori-associated gastritis,and gastric atrophy.METHODS A cross-sectional,nonrandomized study from November 2015 to April 2016 performed in a single-tertiary academic center from Ecuador.Seventy-two consecutive patients with functional dyspepsia according to the Rome III criteria,were tested for H.pylori using a stool antigen test and were assigned to an Hp+group or an Hp-control group.Esophagogastroduodenoscopy with highdefinition optical magnification and digital chromoendoscopy was performed,and patients were classified into 4 groups,in accordance to the microvasculararchitecture pattern of the mucosa.Interobserver and intraobserver agreement among operators were calculated.RESULTS Of the 72 participants,35 were Hp+ and 37 were Hp-.Among 10 patients with normal mucosal histology in biopsy samples,90% had a Type I pattern of microvascular architecture by endoscopy.Among participants with type IIa and type IIb patterns,significantly more were Hp+ than Hp-(32 vs 8),and most(31 out of 40) had histological diagnoses of chronic active gastritis.Two of the three participants with a histological diagnosis of atrophy had a type III microvascular pattern.The type I pattern predicted normal mucosa,type IIa–IIb predicted H.pylori infection,and type III predicted atrophy with sensitivities of 90.0%,91.4%,and 66.7%,respectively.The intraobserver and interobserver agreements had kappa values of 0.91 and 0.89,respectively.CONCLUSION High-definition optical magnification with digital chromoendoscopy is useful for diagnosis of normal gastric mucosa and H.pylori-associated gastritis with high accuracy,but further studies are needed to determine whether endoscopic diagnosis of gastric atrophy is feasible. 相似文献
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中药配合针刺治疗慢性胃炎131例临床疗效分析 总被引:1,自引:0,他引:1
目的 :探讨针药结合及单纯中药治疗慢性胃炎的临床疗效。方法 :1 31例慢性胃炎患者采用针药结合治疗 ,4 7例慢性胃炎患者采用单纯中药治疗 ,1 5d为 1疗程 ,共治疗 3个疗程 ;治疗前后分别记录临床症状及胃镜结果。结果 :1 31例经服中药及针刺治疗 4 5天 ,临床症状明显好转 ,胃粘膜病变明显改善 ,总有效率为91 . 7%;4 7例单纯服用中药治疗 4 5天 ,临床症状明显好转 ,胃粘膜病变改善明显 ,总有效率为 71 . 1 %;两组经统计学分析有显著差异 (P <0 . 0 1 ) ;针药结合组、中药组 ,胃镜结果显示 ,胃粘膜病变程度均有不同的好转 ,但针药结合组疗效明显优于单纯中药组 (P <0 . 0 1 )。结论 :针药结合及单纯服用中药对慢性胃炎临床症状、胃粘膜的修复均有不同程度的改善作用 ,但针药结合组疗效明显优于单纯中药治疗组 ,提示临床治疗各型慢性胃炎 ,应以综合治疗为主。 相似文献
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Li Jian-zhong Zhou Lu Liu Li-gong Zhang De-hua Zhang Rong Zhao Zi-qiang Wang Li-dong Zhang Shi-ying Liu Dong Liu Yun-qing Li Yu-fen Liu Dong-li 《针灸推拿医学(英文版)》2005,3(2):23-25
目的:观察针灸结合治疗慢性萎缩性胃炎的临床疗效.方法:慢性萎缩性胃炎患者36例,按中医辩证,分型施以针灸治疗.治疗前及治疗后均进行胃镜、体表胃电图、胃酸和胃蛋白酶、血中胃泌素、血中前列腺素E及胃粘膜胃泌素细胞等理化指标检查.结果:针灸治疗本病有较好的效果,显效好转率达97.2%,临床症状消失率达97.0%.治疗后可使患者血中前列腺素E等防御性因子增强,使患者从胃内低酸转向正常状态,胃动力功能增强,胃电图幅值回升,并可促使胃泌素释放,有利于胃酸的分泌.结论:针灸治疗萎缩性胃炎简便经济,无副作用,见效快,疗效肯定,可重复性强,具有一定的临床意义. 相似文献
4.
《Best Practice & Research: Clinical Gastroenterology》2016,30(6):913-922
Intestinal-type gastric adenocarcinoma arises from a multistep process starting with Helicobacter pylori infection followed by gastric atrophy, gastric intestinal metaplasia and dysplasia.Indeed, patients with gastric precancerous conditions or lesions (GPC) are at increased risk to develop gastric cancer even in regions with low incidence. Thus, the identification and surveillance of a high risk subgroup could lead to the diagnosis of cancer at early stage and improve survival. However, both endoscopic and histological accuracy and interobserver agreement in the diagnosis of GPC are still far from optimal. Also, there are conceptual differences between the West and the East in the diagnosis and surveillance of patients. In the former, multiple gastric biopsies are still recommended but Eastern gastroenterologists select patients to surveillance according to the results of endoscopy or serology.In this literature review we describe the cascade of GPC and we highlight the differences between eastern and western clinical practice. 相似文献
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An expression/secretion plasmid containing genes encoding the FimA, CP39, PtfA, ToxA and F1P2 antigens associated with porcine pneumonic pasteurellosis and progressive atrophic rhinitis (PAR) was constructed and harbored in an attenuated Salmonella Typhimurium, which was used as the vaccine candidate. The immune responses induced by this delivery strain were investigated in a murine model. Each antigen secreted from the delivery strain was confirmed by Western blot analysis. Thirty BALB/c mice were divided equally into two groups; group A were intranasally inoculated with the mixture of the five delivery strains, and group B were inoculated with sterile PBS. In group A, all antigen-specific serum IgG were significantly increased compared to those of group B from the 2nd week post-inoculation (WPI) till the 8th WPI. All antigen-specific mucosal IgA in group A were also significantly greater than those of group B. In addition, the significant splenic lymphocyte proliferative responses, the elevations of CD3+CD4+, CD3+CD8+ and B-cell populations, and the induction of IFN-γ expression in group A were observed. In conclusion, the mixture of five delivery strains expressing specific antigen for these diseases was found to be capable of inducing significant humoral and cellular immune responses. 相似文献
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背景:愈来愈多的迹象表明胃溃疡(GU)与胃癌发生的危险性增加相关,而十二指肠溃疡(DU)则与胃癌的发生负性相关.目的:研究DU与萎缩性胃炎的相关性.方法:对DU、GU和复合性溃疡(CU)患者胃窦、胃窦胃体交界处和胃体黏膜以及慢性胃炎(CG)患者胃窦黏膜活检标本进行组织学检查,统计各自胃黏膜的萎缩、肠化、慢性炎症、活动性和幽门螺杆菌(H.pylori)感染的发生率及其严重程度.结果:DU患者胃窦、胃窦胃体交界处和胃体黏膜的萎缩发生率分别为54.2%、9.5%和12.4%,肠化发生率分别为18.9%、2.5%和1.5%.其胃窦黏膜肠化的发生率明显低于相应的GU、CU或CG者.3种消化性溃疡和CG患者均存在胃窦部慢性炎症,且消化性溃疡患者胃体部炎症的发生率较高,其胃炎活动性以胃窦部为主,且均较CG者高(P<0.05).DU、GU和CU患者胃窦部Ⅰ型肠化的发生率分别为68.1%、43.8%和45.0%;而其Ⅲ型肠化的发生率则分别为6.4%、25.0%和20.0%(P<0.05).结论:DU患者的胃窦部可有灶性萎缩和肠化发生,其胃窦黏膜肠化发生率和Ⅲ型肠化的发生率最低,这可能是DU患者罹患胃癌危险性较低的原因之一. 相似文献