全文获取类型
收费全文 | 270篇 |
免费 | 7篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 2篇 |
妇产科学 | 4篇 |
基础医学 | 60篇 |
口腔科学 | 2篇 |
临床医学 | 24篇 |
内科学 | 22篇 |
皮肤病学 | 16篇 |
神经病学 | 7篇 |
特种医学 | 24篇 |
外科学 | 49篇 |
综合类 | 5篇 |
预防医学 | 1篇 |
眼科学 | 1篇 |
药学 | 6篇 |
肿瘤学 | 54篇 |
出版年
2023年 | 3篇 |
2022年 | 10篇 |
2021年 | 14篇 |
2020年 | 8篇 |
2019年 | 6篇 |
2018年 | 12篇 |
2017年 | 10篇 |
2016年 | 10篇 |
2015年 | 9篇 |
2014年 | 18篇 |
2013年 | 14篇 |
2012年 | 22篇 |
2011年 | 16篇 |
2010年 | 11篇 |
2009年 | 16篇 |
2008年 | 11篇 |
2007年 | 11篇 |
2006年 | 9篇 |
2005年 | 7篇 |
2004年 | 5篇 |
2003年 | 7篇 |
2002年 | 7篇 |
2001年 | 2篇 |
2000年 | 6篇 |
1999年 | 5篇 |
1998年 | 4篇 |
1997年 | 4篇 |
1996年 | 6篇 |
1995年 | 1篇 |
1994年 | 3篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1991年 | 3篇 |
1990年 | 1篇 |
1988年 | 2篇 |
1987年 | 2篇 |
1986年 | 1篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1982年 | 1篇 |
1981年 | 3篇 |
1976年 | 1篇 |
排序方式: 共有286条查询结果,搜索用时 0 毫秒
1.
Tadashi Terada Yasuni Nakanuma Takeo Matsubara Tetsuo Suematsu 《Pathology international》1988,38(10):1345-1351
The pathology of a rare case of primary diffuse angiosarcoma of the pericardium is reported. Grossly, the heart was entirely encased by the pericardial tumor, and the myocardium was only superficially invaded by the tumor. The tumor tissue extended directly to the mediastinum, where the great vessels were embedded in the tumor. A few minute distant metastases were found only in the bilateral lungs and pulmonary hilar lymph nodes. Microscopically, the tumor tissue was composed of malignant cells forming vascular channels admixed with solid areas. Histo- and immunohistochemically, no mesothelial characteristics were evident. Factor VHI-related antigen and Ulex'europaeus I lectin were positive, implying that the tumor was of vascular origin. Grossly, and in part microscopically, this case resembled malignant diffuse mesothelioma, indicating that pericardial angiosarcoma may sometimes mimick malignant mesothelioma. ACTA PATHOL JPN 38: 1345-1351, 1988. 相似文献
2.
Basement membrane in Kaposi's sarcoma: an immunohistochemical and ultrastructural study 总被引:1,自引:0,他引:1
Basement membranes were investigated in early angiomatous and late sarcomatoid stages of Kaposi's sarcoma (KS). Seven frozen skin biopsies of KS from five elderly Mediterranean people and one renal allograft recipient were labelled, using an immunoperoxidase technique, for basement membrane-specific macromolecules, laminin and type IV-collagen. Twenty-seven other frozen cutaneous lesions including haemangio and lymphangiosarcomas, benign vascular tumours, and various epithelial, melanocytic, fibrohistiocytic, fibrosarcomatous and muscular tumours were processed in the same way. In addition an ultrastructural study was performed in two cases of KS, one haemangiosarcoma and one lymphangiosarcoma. Intense labelling was observed for both type IV-collagen and laminin, which appeared closely co-distributed, in all areas of KS. Staining pattern was often regular and continuous around neoplastic vessels in early lesions of KS, as in benign vascular lesions, whereas in late nodular lesions large amounts of basement membrane components were present in intercellular spaces between densely aggregated spindle cells. In contrast, ultrastructural examination disclosed early disruption of basement membranes around neoplastic vessels, and occasional fragments of external lamina were seen at the interface between KS spindle cells and collagen. Similar results were obtained in angiosarcomas both by immunohistological and ultrastructural study. In the comparative group, laminin and type IV-collagen were present, in significantly fewer quantities and in various distinctive patterns, in epithelial, melanocytic, fibrohistiocytic and muscular tumors. This study deals with basement membrane modifications in early and late lesions of KS and provides further evidence in favour of the endothelial nature of the spindle cells of KS. 相似文献
3.
We report a case of angiosarcoma of the breast and the autopsy findings. The patient was a 35-year-old premenopausal woman
who complained of a tumor in her left breast. We found a tumor measuring 55 mm in diameter in the lower external quadrant.
The tumor was elastic and soft, smooth surfaced, well-defined and mobile. Dimpling sign or change of skin color were not observed.
Clinically it was diagnosed as phyllodes tumor, but tumorectomy revealed primary angiosarcoma of the breast. Further extended
surgery was recommended, but the patient refused additional therapy. Histological findings revealed a free surgical margin
and neither lymph node metastasis nor distant metastasis were clinically observed. Seven months later, local recurrence in
the same breast was recognized and finally radical mastectomy was carried out. Histological findings showed recurrence of
angiosarcoma in the left breast but lymph node metastasis was not detected. Two months after mastectomy, metastases to the
cervical and thoracic vertebrae were observed and radiation therapy was performed. Sixteen months from onset, she died due
to multi-organ failure as general metastases of angiosarcoma. At autopsy, metastases to many organs including the digestive
system were observed. The incidence of primary angiosarcoma of the breast is low but its prognosis is poor. This case emphasized
the difficulties in clinical diagnosis and treatment for the angiosarcoma of the breast. 相似文献
4.
目的探讨乳腺根治术继发淋巴水肿后的上臂皮肤血管肉瘤,即STS的临床病理学特征及诊断、鉴别诊断要点。方法对1例STS进行病理组织学及免疫组织化学染色观察,并复习相关文献。结果镜下以充满红细胞的大小不等的囊腔,相互沟通的不规则的管腔,部分由梭形和上皮样细胞构成的实性区域为特征。不规则的管腔内衬覆异型瘤细胞,可见单个或多个瘤细胞形成空腔内含红细胞。免疫组织染色肿瘤细胞CD34阳性、CD31阳性,Ki-67部分阳性,AE1/AE3为阴性表达。结论 STS是乳腺血管肉瘤的一种特殊类型,免疫组织化学检测有助于诊断和鉴别诊断。 相似文献
5.
Tomas V. Gonzalez Tiffany M. Sae-Kho Steven I. Robinson Tina J. Hieken Andrew L. Folpe Stephen M. Broski Amy C. Degnim Katrina N. Glazebrook 《Radiology Case Reports》2022,17(10):3624
Radiation-associated angiosarcoma of the breast (RAASB) is a rare and aggressive malignancy occurring after radiation therapy as part of breast cancer treatment. RAASB usually presents several years after prior radiation and typically involves the skin with or without involvement of the parenchyma. Most RAASB are detected as cutaneous changes on physical exam. Herein, we present a unique case of a clinically occult RAASB diagnosed as non-mass enhancement on annual surveillance breast MRI. 相似文献
6.
The authors describe a primary sarcoma of the brain with immunohistochemical and ultrastructural features of leiomyosarcoma as well as epithelioid hemangiosarcoma. The leiomyosarcomatous component consisted of spindle cells with well-developed external lamina, subsarcolemmal densities composed of microfilaments, pinocytic vesicles, and abundant intermediate filaments, and showed immunohistochemical reactions for smooth muscle actin. The epithelioid part of the tumor contained scattered cells reactive for alkaline phosphatase as well as CD31 and factor VIII. Many epithelioid cells were lipidized and remarkably similar to "stromal cells" of a hemangioblastoma. Occasional Weibel-Palade bodies, indicating endothelial differentiation, were present in scattered neoplastic cells. There were also cells with features intermediate between endothelium, pericytes and smooth muscle cells, and undifferentiated mesenchymal cells. The brain at the periphery of sarcoma showed conglomerates of well-differentiated capillaries, telangiectasias and small dysplastic arteries, features that raise the possibility of origin of this tumor from a preexisting vascular developmental abnormality. 相似文献
7.
8.
9.
10.
Smit Singla Pavlos Papavasiliou Benjamin Powers John Gaughan Margaret von Mehren James C. Watson Jeffrey M. Farma 《American journal of surgery》2014