全文获取类型
收费全文 | 2448篇 |
免费 | 146篇 |
国内免费 | 162篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 10篇 |
妇产科学 | 3篇 |
基础医学 | 93篇 |
口腔科学 | 8篇 |
临床医学 | 271篇 |
内科学 | 1344篇 |
皮肤病学 | 5篇 |
神经病学 | 67篇 |
特种医学 | 154篇 |
外科学 | 310篇 |
综合类 | 287篇 |
预防医学 | 33篇 |
眼科学 | 10篇 |
药学 | 93篇 |
1篇 | |
中国医学 | 5篇 |
肿瘤学 | 48篇 |
出版年
2024年 | 2篇 |
2023年 | 43篇 |
2022年 | 53篇 |
2021年 | 86篇 |
2020年 | 98篇 |
2019年 | 79篇 |
2018年 | 77篇 |
2017年 | 61篇 |
2016年 | 57篇 |
2015年 | 106篇 |
2014年 | 195篇 |
2013年 | 254篇 |
2012年 | 136篇 |
2011年 | 155篇 |
2010年 | 119篇 |
2009年 | 131篇 |
2008年 | 149篇 |
2007年 | 163篇 |
2006年 | 132篇 |
2005年 | 114篇 |
2004年 | 100篇 |
2003年 | 75篇 |
2002年 | 89篇 |
2001年 | 60篇 |
2000年 | 39篇 |
1999年 | 36篇 |
1998年 | 41篇 |
1997年 | 26篇 |
1996年 | 20篇 |
1995年 | 20篇 |
1994年 | 16篇 |
1993年 | 12篇 |
1992年 | 8篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 2篇 |
排序方式: 共有2756条查询结果,搜索用时 15 毫秒
1.
Intracranial Angioplasty and Stenting in the Awake Patient 总被引:1,自引:0,他引:1
Alex Abou-Chebl MD Derk W. Krieger MD Christopher T. Bajzer MD Jay S. Yadav MD FACC 《Journal of neuroimaging》2006,16(3):216-223
BACKGROUND AND PURPOSE: Endovascular treatment for intracranial atherosclerosis is evolving, but complications remain an issue. Most interventions are performed under general anesthesia, preventing intraprocedural clinical evaluations. We describe our approach to intracranial angioplasty and stenting, using local rather than general anesthesia, and intraprocedural neurological assessment. METHODS: We prospectively collected procedural and outcome information on all patients undergoing intracranial angioplasty and stenting. Patients underwent interventions under local anesthesia with mild intravenous sedation or analgesia only if needed. Intraoperative neurological evaluations were performed, and symptomatology was used to guide the interventional technique. RESULTS: Forty-eight arteries in 40 patients with a mean age of 65.2 years were treated. Thirty-two anterior and 16 posterior circulation segments were treated. Technical success was achieved in 100% of patients with reduction of the mean pretreatment stenosis from 85 +/- 8.6% to 7 +/- 10.1%. Stents were deployed in 40 segments; five patients were treated with drug-eluting stents. The cobalt-chromium coronary stents were the easiest to deliver. Thirty-seven patients were treated under local anesthesia and, of those, 61.4% experienced intraprocedural symptoms that led to some alteration of the interventional technique. Headache was the most common symptom, and, when persistent, it heralded the occurrence of subarachnoid hemorrhage. There were seven total neurological complications, but only five (10.5%) led to permanent morbidity (4 strokes) or mortality (1 death). CONCLUSIONS: Intracranial angioplasty and stenting can be successfully performed using coronary techniques and equipment including drug-eluting stents. Local anesthesia permits neurological evaluations and often leads to the adjustment of the interventional technique, potentially making the procedure safer. 相似文献
2.
Reports the case of a 60-year-old woman who underwent R2 total gastrectomy, and subsequent palliation of painful symptom
recurrence via a membrane-covered metal stent.
Received: 13 June 1996/Accepted: 31 July 1996 相似文献
3.
The aim of this study was to determine whether the use of bactericidal coatings or immersion in antibiotic solution reduces or prevents bacterial adhesion onto ureteric stents. Precut segments of full silicone, silver-coated and hydrogel-coated ureteric stents were incubated with two uropathogenic bacterial strains with and without previous immersion in antibiotic solution. Tobramycin, ceftriaxone and ciprofloxacin solutions were used, as these antibiotics are commonly administered for the prophylaxis and treatment of urinary tract infection (UTI). Microbiological analysis showed that immersion of ureteric stents in ceftriaxone and ciprofloxacin yielded a significant reduction of bacterial adhesion, whereas immersion in tobramycin did not. The surface material of the stents had no direct influence on bacterial adhesion. In this experimental study, neither the silver nor the hydrogel coat reduced bacterial adhesion onto ureteric stents whereas immersion in a suitable antibiotic solution significantly reduced and even prevented this phenomenon, probably due to the adhesion of the antibiotic onto the stent surface. Prevention of bacterial adhesion onto ureteric stents is essential to reduce the risk of UTI in connection with these devices. 相似文献
4.
5.
Irwin S. Johnsrude William M. Bogey Jr Michael D. Tripp 《Cardiovascular and interventional radiology》1994,17(6):336-338
Discovery of a postlumbosacral discectomy fistula between the right iliac artery and vein was obscured by an associated severe stricture of the infrarenal inferior vena cava in a 49-year-old man. During venous stenting for treatment of peripheral edema, the fistula was suspected because of faint pulsatile right iliac vein flow and increased O2 saturation of the venous blood. The suspicion was confirmed on subsequent iliac arteriography. Surgical closure of the fistula with arterial interposition grafting was then performed. The patient improved substantially. 相似文献
6.
PTCA及血管内支架术中冠脉循环血小板功能的变化 总被引:11,自引:4,他引:7
目的 探讨经皮腔内冠脉成形术(PTCA)及冠脉内支架术对冠脉循环中血小板功能的影响。方法 29例冠心病患者分成冠脉造影组(8例)和PTCA加支架组(21例),分别于术前及术后即刻采集冠状静脉窦血,采用比浊法测定血小板最大聚集率(MPAR),放免法测定血小板α-颗粒膜蛋白(GMP-140)及血栓素B2(TXB2)的浓度。并对PTCA及支架术中不同时间点血小板功能指标的变化情况进行了观察。结果 冠脉造影前后血小板功能指标无显著变化;PTCA及支架组在球囊预扩张即刻各血小板功能指标均轻度增高;支架后即刻显著升高(P<0.05),支架后10min有下降趋势。结论 冠脉造影对冠脉循环血小板功能无显著影响;PTCA及支架术中能使血小板功能激活。 相似文献
7.
覆膜自膨式金属支架治疗恶性食管气管瘘 总被引:2,自引:1,他引:1
目的 探讨覆膜金属支架治疗恶性食管气管瘘的效果及并发症。方法 在X线引导下14例食管气管瘘用国产覆膜支架治疗,门诊行食管造影或电话随访。结果 除1例瘘口封堵不全外,其余13例瘘口完全封堵,未发生因操作引起的并发症。8例进普食,6例进半流食,12例肺部感染得到控制。并发症:严重胸痛3例,支架移位致瘘再开放1例,颈动脉及左侧喉返神经受压致头晕及咽麻痹各1例。8例病人死亡,术后生存时间1.4~12个月, 相似文献
8.
目的 评价冠状动脉支架植入术临床效果。方法 19例冠心病患者被植入支架共20枚,其中男性17例,女性2例,年龄31~70岁,急性心肌梗塞12例,陈阳性心肌梗塞3例,不稳定性心绞痛4例。结果 全部支架植入成功。结论 冠状动脉内支架植入术成功率高,并发症少,为安全有效的冠心病临床治疗技术。 相似文献
9.
西京医院冠心病介入治疗537例 总被引:1,自引:1,他引:0
目的 总结西京医院冠心病介入治疗的成功率及并发症发生率 .方法 回顾性分析 1998- 12前所有冠心病介入治疗病历完整患者的临床资料 .结果 在 5 37例患者中 ,6 9.3%为不稳定性心绞痛 ,2 0 .3%射血分数≤ 40 .0 % ,6 4.6 %为多支病变 .治疗血管 6 71支、病变 76 9处 ,B,C型病变77.9% .介入治疗病例成功率为 89.2 % .病变成功率 89.1% ,严重并发症发生率为 3.4% (死亡 1.9% ,Q波心梗 2 .0 % ,急症冠脉搭桥术 0 .2 % ) .普遍应用支架前后对比 ,病例成功率提高 (91.0 % vs80 .0 % ,P<0 .0 1) ,严重并发症发生率下降 (2 .6 % vs 6 .4% ,P<0 .0 5 ) .结论 我院病例病情严重 ,介入治疗成功率和并发症发生率与国外文献报道相似 .支架提高了介入治疗的安全性 相似文献
10.
Self-expanding oesophageal metal stents for the palliation of dysphagia due to extrinsic compression
The role of self-expanding metallic stents is well established in the palliation of oesophageal stenosis and dysphagia due
to primary oesophageal malignancy. However, their role in palliation of dysphagia due to external compressive mediastinal
malignancies is not well established. The purpose of this study was to assess the efficacy of self-expanding metallic stents
in the palliation of dysphagia due to extrinsic oesophageal compression by mediastinal malignancy. Between January 1995 and
January 1998, 21 patients with oesophageal compression due to malignant mediastinal tumours underwent oesophageal stent placement
for palliation of dysphagia. Complete data were available in 17 patients (10 men and 7 women). The mean age was 63.5 years
(range 46–89 years). A total of 19 stents were placed successfully. The dysphagia grade prior to and after oesophageal stent
placement was assessed and the complications documented. Of the 17 patients, 16 reported an improvement in dysphagia. The
mean dysphagia score improved from 3.1 prior to treatment to 1.3 after treatment. In 1 patient the stent slipped during placement
and another stent was placed satisfactorily. Early complications (within 48 h) in the form of mild to moderate retrosternal
chest pain occurred in 5 patients. This was treated symptomatically. Late complications (after 48 h) in the form of bolus
impaction occurred in 2 patients. This was successfully treated with oesophagoscopy and removal of bolus. In 2 patients the
stent was overgrown by tumour and in one of these an additional stent was placed. In 1 patient incomplete closure of a tracheo-oesophageal
fistula was observed. There was no procedure- or stent-related mortality. The mean survival time of this group was 2.1 months.
Self-expanding metallic stents can be safely and effectively used in the palliation of dysphagia due to external mediastinal
malignancies.
Received: 21 October 1998; Revised: 1 February 1999; Accepted: 4 February 1999 相似文献