Electronic patient-provider communication: will it offset office visits and telephone consultations in primary care?

BACKGROUND AND AIM: Electronic patient-provider communication promises to improve efficiency and effectiveness of clinical care. This study aims to explore whether a secure web-based messaging system is an effective way of providing patient care in general practices. METHOD: We conducted a randomised controlled trail and recruited 200 patients from the waiting area in one primary clinic in Norway. Participants were randomised to either the intervention group, which received access to a secure messaging system, or the control group receiving standard care without such access. Primary outcome measures were number of online consultations, telephone consultations and office visits in the two groups. Data were derived from patient records and collected 1 year prior to (baseline), and 1 year after the intervention. RESULTS: Forty-six percent of the patients who were given access to the messaging system (n=99) used the online communication system on at least one occasion (ranging from 1 to 17 messages per patient per year). A total of 147 electronic messages were sent to six general practitioners during a 1-year trial period. Eleven percent of the messages were to schedule an appointment. In 10% of the messages, the GP was unable to respond adequately and recommended an office visit. The reduction in office visits over time was greater for the intervention group than for the control group (P=0.034). There was however no significant difference in the number of telephone consultations between the groups during the study (P=0.258). CONCLUSION: The use of a secure electronic messaging system reduced the number of office visits at the general practice, but not phone consultations.     

基于智能化平台的医院配电系统安全探讨

结合实例,对医院建设配电安全平台的需求进行分析,阐述了配电安全平台的开发思路及系统功能,总结出应用配电智能化系统的成效.     

Transiently Transfected Mammalian Cell Cultures: An Adaptable and Effective Platform for Virus-like Particle-Based Vaccines against Foot-and-Mouth Disease Virus

RNA viruses, such as foot-and-mouth disease virus (FMDV), have error-prone replication resulting in the continuous emergence of new viral strains capable of evading current vaccine coverage. Vaccine formulations must be regularly updated, which is both costly and technically challenging for many vaccine platforms. In this report, we describe a plasmid-based virus-like particle (VLP) production platform utilizing transiently transfected mammalian cell cultures that combines both the rapid response adaptability of nucleic-acid-based vaccines with the ability to produce intact capsid epitopes required for immunity. Formulated vaccines which employed this platform conferred complete protection from clinical foot-and-mouth disease in both swine and cattle. This novel platform can be quickly adapted to new viral strains and serotypes through targeted exchanges of only the FMDV capsid polypeptide nucleic acid sequences, from which processed structural capsid proteins are derived. This platform obviates the need for high biocontainment manufacturing facilities to produce inactivated whole-virus vaccines from infected mammalian cell cultures, which requires upstream expansion and downstream concentration of large quantities of live virulent viruses.     

论中药工业中的中试放大验证

本文对中药制药工程技术的四要素之一-中药施工与验证进行探讨,从中药研究成果转化为大规模生产的过程中一般都将发生质的变化,许多重大工程技术问题也往往出现在这一阶段。因此,中试放大验证至关重要,也中药现代化的关键。本文论述了在实现中药大规模生产过程中进行中试放大验证的必要性,主要技术内容,应达到的目标,并就中试放大验证平台的建设,基本功能与任务,运行等进行了详细介绍。     

中医馆健康信息平台建设与发展的思考

在深入分析中医馆健康信息平台建设现状和存在问题的基础上,提出相应对策和建议,以期进一步优化升级中医馆健康信息平台,更好地满足用户需求和业务需求。     

三维重建结合3D打印技术在辅助复杂胫骨平台骨折手术中的应用研究

目的：观察在复杂胫骨平台骨折手术治疗中使用三维重建结合3D打印技术的治疗效果。方法：选取2017年3月—2019年10月在廉江市人民医院接受复杂胫骨平台骨折手术的72例患者,按照随机分组法分为对照组与观察组,各36例。对照组应用常规手术治疗法,观察组应用三维重建结合3D打印技术。观察两组临床指标、膝关节功能及运动功能、并发症发生率。结果：治疗前,两组膝关节功能及运动功能评分对比无显著差异（P> 0.05）;治疗后,观察组术中出血量、术中透视次数少于对照组,手术时间、住院时间及骨折愈合时间短于对照组,差异有统计学意义（P <0.05）。治疗后,观察组膝关节功能及运动功能评分均显著高于对照组（P <0.05）。观察组并发症发生率低于对照组,差异有统计学意义（P <0.05）。结论：在复杂胫骨平面骨折手术治疗中使用三维重建结合3D打印技术,有助于优化患者的手术指标,提升膝关节功能及运动功能,降低并发症发生率,手术效果显著。     

Biomaterial-based platforms for cancer stem cell enrichment and study

Cancer stem cells (CSCs) are a relatively rare subpopulation of tumor cell with self-renewal and tumorigenesis capabilities. CSCs are associated with cancer recurrence, progression, and chemoradiotherapy resistance. Establishing a reliable platform for CSC enrichment and study is a prerequisite for understanding the characteristics of CSCs and discovering CSC-related therapeutic strategies. Certain strategies for CSC enrichment have been used in laboratory, particularly fluorescence-activated cell sorting (FACS) and mammosphere culture. However, these methods fail to recapitulate the in vivo chemical and physical conditions in tumors, thus potentially decreasing the malignancy of CSCs in culture and yielding unreliable research results. Accumulating research suggests the promise of a biomaterial-based three-dimensional (3D) strategy for CSC enrichment and study. This strategy has an advantage over conventional methods in simulating the tumor microenvironment, thus providing a more effective and predictive model for CSC laboratory research. In this review, we first briefly discuss the conventional methods for CSC enrichment and study. We then summarize the latest advances and challenges in biomaterial-based 3D CSC platforms. Design strategies for materials, morphology, and chemical and physical cues are highlighted to provide direction for the future construction of platforms for CSC enrichment and study.     

利用信息技术提高河南省出生缺陷防治管理水平

目的 总结通过信息平台,提高出生缺陷防控水平的经验和挑战.方法 回顾性总结系统中出生缺陷三级预防措施落实,沿胎儿生命周期获取功能和代谢障碍缺陷个案的数据并进行总结分析.结果 平台促进了出生缺陷三级预防措施落实.系统包括11 912例有遗传病或缺陷儿家族史的孕妇信息,433例染色体和基因异常胎儿产前诊断记录,7977例结...     

停课不停学背景下对机能学实验虚拟实验平台建设的思考

北京中医药大学积极响应教育部"停课不停学"的要求,借助机能学实验虚拟实验平台切实保障机能学实验教学工作的顺利开展。此文通过对"停课不停学"背景下的机能学实验课程以及机能学实验虚拟实验平台进行系统思考,并且结合问卷调查、教师走访、纵向比较等方法,分析"停课不停学"背景下机能学实验虚拟实验平台的使用效果和不足之处,旨在为虚拟实验"金"平台的建设提供参考和思路。