全文获取类型
收费全文 | 3467篇 |
免费 | 306篇 |
国内免费 | 80篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 86篇 |
妇产科学 | 25篇 |
基础医学 | 618篇 |
口腔科学 | 136篇 |
临床医学 | 371篇 |
内科学 | 307篇 |
皮肤病学 | 50篇 |
神经病学 | 130篇 |
特种医学 | 101篇 |
外科学 | 177篇 |
综合类 | 563篇 |
一般理论 | 1篇 |
预防医学 | 634篇 |
眼科学 | 25篇 |
药学 | 287篇 |
6篇 | |
中国医学 | 244篇 |
肿瘤学 | 76篇 |
出版年
2024年 | 10篇 |
2023年 | 70篇 |
2022年 | 101篇 |
2021年 | 134篇 |
2020年 | 124篇 |
2019年 | 114篇 |
2018年 | 107篇 |
2017年 | 117篇 |
2016年 | 149篇 |
2015年 | 118篇 |
2014年 | 200篇 |
2013年 | 220篇 |
2012年 | 215篇 |
2011年 | 247篇 |
2010年 | 183篇 |
2009年 | 179篇 |
2008年 | 181篇 |
2007年 | 167篇 |
2006年 | 185篇 |
2005年 | 141篇 |
2004年 | 114篇 |
2003年 | 106篇 |
2002年 | 97篇 |
2001年 | 79篇 |
2000年 | 50篇 |
1999年 | 60篇 |
1998年 | 43篇 |
1997年 | 39篇 |
1996年 | 36篇 |
1995年 | 34篇 |
1994年 | 33篇 |
1993年 | 18篇 |
1992年 | 18篇 |
1991年 | 21篇 |
1990年 | 21篇 |
1989年 | 17篇 |
1988年 | 13篇 |
1987年 | 12篇 |
1986年 | 10篇 |
1985年 | 11篇 |
1984年 | 10篇 |
1983年 | 5篇 |
1982年 | 9篇 |
1981年 | 10篇 |
1980年 | 7篇 |
1979年 | 5篇 |
1978年 | 4篇 |
1977年 | 2篇 |
1971年 | 2篇 |
1970年 | 2篇 |
排序方式: 共有3853条查询结果,搜索用时 31 毫秒
1.
2.
《Journal of vascular and interventional radiology : JVIR》2020,31(6):869-875
This paper describes country-wide special measures undertaken for interventional radiology staff during the current coronavirus disease 2019 (COVID-19) pandemic. Although each interventional radiology service around the world faces unique challenges, the principles outlined in this article will be useful when designing or strengthening individual practices and integrating them within wider hospital and national measures. Moving beyond the current outbreak, these measures will be useful for any future infectious diseases which are likely to arise. 相似文献
3.
[摘要] 目的 探究HBV相关慢加急性肝衰竭(HBV-related acute-on-chronic liver failure, HBV-ACLF)患者血清中微小核糖核酸(microRNA, miR)-122和高迁移率族蛋白1(high-mobility group box-B1, HMGB1)水平及其与病情、预后的关系。方法 回顾性分析2016年1月—2018年1月我院收治的120例HBV-ACLF患者的一般及临床资料。根据临床结局,将患者分为存活组(53例)和死亡组(67例)。比较2组患者的一般资料、实验室检查指标及血清miR-122、HMGB1水平。多因素Logistic回归分析影响患者预后的因素。Pearson检验分析miR-122、HMGB1水平分别与TBIL、PA、终末期肝病评分模型(the model of end-stage liver disease score, MELD)评分的相关性。ROC曲线分析miR-122和HMGB1水平对患者的死亡预测价值,获得最佳临界值。根据临界值将患者分为A组、B组和C组,用Kaplan-Meier法绘制生存曲线,比较3组患者在3年随访期间的生存率。结果 存活组和死亡组患者的年龄、身体质量指数、并发症、病情分期、MELD评分、ALB、球蛋白、TBIL、ALT、AST、LDH、PT、PTA、HBV DNA、miR-122、HMGB1相比,差异均具有统计学意义(P均<0.05)。年龄、并发症、病情分期、MELD评分、TBIL、PT、PTA、miR-122、HMGB1均是影响患者预后的危险因素(P均<0.05)。miR-122、HMGB1水平分别与TBIL、MELD评分呈显著正相关,与PTA呈显著负相关(P均<0.05)。miR-122和HMGB1预测患者死亡的最佳临界值分别为31.42和14.56 μg/L。A组患者预后3年内生存率显著高于B组和C组(P均<0.05)。结论 miR-122和HMGB1水平与HBV-ACLF患者的病情和死亡预后密切相关,可间接反映患者的病情严重程度,在HBV-ACLF的诊断及预后中具有重要价值。 相似文献
4.
Paediatric palliative care and neurodisability are two relatively new, evolving paediatric sub-specialities that have increasing relevance in the current paediatric landscape. For many people palliative care has been synonymous with end of life care, but in paediatrics it encompasses much more and is for all children with life-threatening or life-limiting conditions, from the point of diagnosis. This breadth of focus is demonstrated well through the interface between paediatric palliative care and paediatric neurodisability. In this article we explore this unique interface through the three domains of complex symptom management, advanced care planning and end of life care. We describe the practicalities involved in all three areas and highlight the importance of early referral and the process of “dual” or “parallel” planning. We cover in more depth the specific management of the symptoms: dystonia/abnormalities of muscle tone, seizures, pain, agitation, secretions, respiratory failure, and gut failure. 相似文献
5.
Allergen content in dust from homes and schools in northern Norway in relation to sensitization and allergy symptoms in schoolchildren 总被引:2,自引:0,他引:2
L. K. DOTTERUD T. D. VAN B. KVAMMEN† T. DYBENDAL‡ S. ELSAYED E. S. FALK 《Clinical and experimental allergy》1997,27(3):252-261
Background Previous studies have shown a high prevalence of atopic diseases among school children in the community of Sør-Varanger. Moreover, animal dander followed by pollen und house dust mite, were the most common allergens in skin prick tests. Objective To assess the allergen content in homes (living-rooms and mattresses) and classrooms of children living in an arctic area at 70° north. The presence of allergens in homes and schools and their relationship to atopy was of particular interest. Methods Dust samples from 38 homes and seven schools in northern Norway were collected by vacuum cleaning. The presence of allergens of dog, birch, timothy, Cladosporium herbanun, codfish and hen egg-white was investigated by radio-allergosorbent test (RAST) inhibition and the presence of major allergens of cat Felis domesticus (Fel d I) and house dust mites (HDM) Dermatophagoides pteronyssinus (Derp I) and Dermatophagoides farinae (Derf I) by enzyme-linked immunosorbent assay (ELISA). Results Mattresses contained significantly more dust per unit area than living-rooms and classrooms. No statistically significant differences in allergen content for dog. birch, timothy, Cladosporium, codfish and hen egg-white were seen between HDM-sensitized and non-atopic children. Most dust samples contained dog allergens with the highest allergenic activity found in living-rooms of those keeping dogs. An increased level of Feld I was detected in only one of 38 samples from living-rooms (this family kept a cat) and in 25 of 38 samples from mattresses with ranges from 24 to 84ng/m2. The highest concentrations were found in mattresses of children keeping cats. Increased levels ( 25 ng/m2) of Derp I were found only in homes and virtually only in mattresses of HDM-sensitized children. An increased level of Derf] was found in only one case, i.e. in the mattress of an HDM-sensitized child where additionally Der p I and HDMs were demonstrated microscopically. When relating Der p I to HDMsensitization an odds ratio of more than 16 (95% Cl: 1.6–394.3) was found. All extracts from living-rooms included codfish allergens. Low RAST inhibition values were detected for hen egg-white, Cladosporium, birch and timothy pollen in most samples. Furthermore, the study demonstrated that dust from schools was relatively free of allergens. Conclusion Previous findings indicating that the main allergen exposure problem in this geographical area is that of pet allergens were confirmed. 相似文献
6.
目的 为临床研究肝硬化提供有价值的手段。方法 采用99mTc -RBC测定 93例肝硬化患者肝血流 ,选择峰时 (Tmax) ,半廓清时 (T1/2 )、廓清率 (K值 )、肝血流 (LBF)等作为观察指标 ,与正常对照组比较 ;同时用99mTc-MIBI经直肠给药测定其中 5 4例患者门静脉压力 (PVP) ,以心 /肝 (H/L)比值作为分流指数。结果 肝硬化组Tmax、T1/2 、K及LBF分别为 1.2 6± 0 .99(93)min、5 .75± 3.38(93)min、0 .15 4± 0 .116 (93)及 0 .6 10± 0 .2 89(93)L/min ,除Tmax外 ,与对照组均有非常显著性差异 ;Child -A、B、C级各组之间 (除Tmax外 )也均有非常显著性差异或显著性差异 ;Child -A、B、C级各组H/L分别为 0 .49± 0 .18(2 1)、0 .6 9± 0 .16 (15 )、0 .91± 0 .2 1(18) ;PVP分别为 2 .2 2± 0 .5 7(2 1)kPa、2 .85± 0 .38(15 )kPa及 3.5 4± 0 .6 5 (18)kPa。而对照组的H/L及PVP分别为 0 .30± 0 .12 (16 )及 1.6 1± 0 .38(16 )kPa。Child -A、B、C级各组分别与对照组及各组之间比较 ,除Child -B与C级组PVP无显著性差异 (P >0 .0 5 )外 ,其余均有非常显著性差异 (P <0 .0 1)及显著性差异 (P <0 .0 5 )。结论 本法测定肝血流及门脉压力方便 ,无创伤 ,对分析病情 ,判断疗效 ,指导制订治疗方案 ,估计预后等均有较 相似文献
7.
目的了解大学生核黄素营养状况,并探讨其影响因素。方法对护理、预防专业的学生进行核黄素4h负荷尿试验,用荧光光度法测定核黄素含量。结果护理学专业的学生核黄素不足的占78.79%,正常占10.10%,充裕的占11.31%。预防医学专业的学生核黄素不足的占74.42%,正常的占16.28%,充裕的占9.3%。专业之间差异无显著性意义(P〉0.05)。结论大学生的核黄素营养水平普遍较低,其中动物性食品摄人较少、学生对合理膳食的营养知识缺乏是核黄素摄人不足的主要原因。 相似文献
8.
L. van den Bemt M. P. de Vries L. van Knapen M. Jansen M. Goossens J. W. M. Muris C. P. van Schayck 《Clinical and experimental allergy》2006,36(2):233-237
BACKGROUND: Exposure to a high level of house dust mite allergens (HDMAs) is considered as a risk factor for HDM sensitization and development of asthma in genetically disposed people. Mattresses are one of the most important sources of HDMA in people's living environment. OBJECTIVE: The aim of this study was to evaluate the association between mattress characteristics and HDMA concentrations on mattresses. METHODS: Dust samples of mattress surfaces were taken to evaluate the level of Der p 1 allergen. All participants filled in a questionnaire about the type of mattress, the type of covering (upper layer) of the mattress, dwelling characteristics and cleaning habits. Humidity and temperature of the bedroom were measured at the time of dust sampling. RESULTS: One hundred and sixty-eight questionnaires were filled in. Synthetic upper layer of the mattress was associated with a higher level of Der p 1 compared with cotton upper layer (2.6 vs. 0.8 microg/g Der p 1). Moreover, higher relative humidity (RH) was associated with significant higher concentrations and density of Der p 1. CONCLUSIONS: Two factors were associated with lower levels of Der p 1 found on mattresses, namely: a cotton upper layer of the mattress compared with a layer of synthetic material and lower RH at the time of sampling. As far as we know, the association between type of upper layer and concentration of Der p 1 has not been described before and could lead to the formulation of practical advices in order to reduce HDMA concentrations on mattresses. 相似文献
9.
本文报告了乌鲁木齐县两种不同类型住宅的卫生设施状况,重点对上下水设施,厕所及周围卫生状况进行了调查。结果表明:小二楼住宅有给排水设施及卫生间;砖土木结构平房内只有上水(自来水),但无下水道及卫生间。因均饮用城市自来水,故两类住宅人群肠道传染病发病率无显著性差异(P>0.05)。对B村六年几种肠道传染病发病率的动态分析表明,改水是预防和降低肠道传染病发病的有效措施。调查结果还表明,住宅设施完善与否, 相似文献
10.
门脉高压性胃病患者的胃壁血气变化 总被引:1,自引:0,他引:1
作者观测了43例门脉高压症患者股动脉血PO2、胃网膜有动静脉胃壁支血PO2、胃壁支静脉及肘静脉血pH、HCO3-和胃网膜右静脉压力,其中23例并有非出血期门脉高压性胃病。结果表明:①门脉高压症患者的股动脉血PO2低于对照组;②门脉高压症患者胃网膜右动静脉胃壁支血氧分压差低于对照组,胃网膜右静脉压力高于对照组,胃壁支静脉血pH和HCO3-低于对照组和同组肘静脉血。并有门脉高压性胃病者这些变化更为显著。提示门脉高压性胃病的发病机制在于门脉系压力增高、胃粘膜下动静脉短路开放、胃粘膜缺血缺氧和胃壁局部酸中毒。 相似文献