手法整复可调式外固定支具治疗第5掌骨颈骨折临床研究

目的:探讨可调式外固定支具治疗第5掌骨颈骨折的可行性及有效性。方法:选取2014年1月～2017年6月我院收治的54例第5掌骨颈骨折患者作为研究对象,随机分为A组和B组,每组27例。A组行闭合复位交叉克氏针固定,B组行手法整复可调式外固定支具固定,比较两组末次随访第5掌指关节活动度和主观满意度。结果:随访4～10个月,两组患者第5掌指关节活动度(ROM)值相比较,差异无统计学意义,P0.05;两组的主观满意度相比较,差异无统计学意义,P0.05。结论:手法整复可调式外固定支具固定可为第5掌骨颈骨折提供可靠、有效的固定,有助于患者的早期功能恢复,是一种有效的治疗方法。     

Mutations in the fifth immunoglobulin-like domain of kit are common and potentially sensitive to imatinib mesylate in feline mast cell tumours

The purpose of the current study was to investigate the mutation status of KIT in feline mast cell tumours (MCTs) and to examine the effects of tyrosine kinase inhibition on the phosphorylation of mutant kit in vitro and in clinical cases of cats. Sequence analysis of KIT identified mutations in 42/62 MCTs (67·7%). The vast majority of the mutations were distributed in exons 8 and 9, both of which encode the fifth immunoglobulin-like domain (IgD) of kit. All five types of kit with a mutation in the fifth IgD were then expressed in 293 cells and examined for phosphorylation status. The mutant kit proteins showed ligand-independent phosphorylation. The tyrosine kinase inhibitor imatinib mesylate suppressed the phosphorylation of these mutant kit proteins in transfectant cells. In a clinical study of 10 cats with MCTs, beneficial response to imatinib mesylate was observed in 7/8 cats that had a mutation in the fifth IgD of kit in tumour cells. Mutations in the fifth IgD of kit thus appear to be common and potentially sensitive to imatinib mesylate in feline MCTs. These data provide an in vivo model for paediatric mastocytosis where mutations in the fifth IgD of kit also occur.     

Electrically Parallel Three-Element 980 nm VCSEL Arrays with Ternary and Binary Bottom DBR Mirror Layers

To meet the performance goals of fifth generation (5G) and future sixth generation (6G) optical wireless communication (OWC) and sensing systems, we seek to develop low-cost, reliable, compact lasers capable of sourcing 5–20 Gb/s (ideally up to 100 Gb/s by the 2030s) infrared beams across free-space line-of-sight distances of meters to kilometers. Toward this end, we develop small arrays of electrically parallel vertical cavity surface emitting lasers (VCSELs) for possible future use in short-distance (tens of meters) free-space optical communication and sensing applications in, for example, homes, data centers, manufacturing spaces, and backhaul (pole-to-pole or pole-to-building) optical links. As a starting point, we design, grow by metal–organic vapor phase epitaxy, fabricate, test, and analyze 980 nm top-emitting triple VCSEL arrays. Via on-wafer high-frequency probe testing, our arrays exhibit record bandwidths of 20–25 GHz, optical output powers of 20–50 mW, and error-free data transmission at up to 40 Gb/s—all extremely well suited for the intended 5G short-reach OWC and sensing applications. We employ novel p-metal and top mesa inter-VCSEL connectors to form electrically parallel but optically uncoupled (to reduce speckle) arrays with performance exceeding that of single VCSELs with equal total emitting areas.     

国人第5百分位女性行人下肢生物力学计算模型开发及应用

目的 预测与评估行人-汽车碰撞中小身材女性行人下肢的生物力学响应及损伤机制。方法 基于符合国人第5百分位女性特征的志愿者CT影像数据,重构具有详细解剖学结构的下肢几何模型,进行表面处理和网格化后,构建下肢有限元计算模型。重构动态三点弯曲尸体试验以及高速载荷下膝关节横向弯曲和剪切尸体试验,对模型进行有效性验证。应用该模型参照Euro NCAP技术公告TB024设置4组行人下肢-汽车碰撞仿真试验,探究第5百分位女性行人下肢损伤机制。结果 通过对比仿真试验与尸体试验结果,验证该模型具有较高的生物仿真度。在4种不同车型仿真试验结果中,SUV车型对下肢损伤最轻。小身材女性下肢股骨最易发生骨折,长骨最先骨折,使得膝关节韧带未见损伤。结论 本文所建下肢有限元模型作为国人第5百分位整人模型开发的一个重要组成部分,为模型研发奠定基础。研究结果对小身材女性行人损伤机制研究和行人保护装置研发有重要的应用价值。     

第五跖骨基底部骨折中医药疗效观察

目的：观察中药、针灸结合体疗方式治疗第五跖骨基底部骨折的临床疗效。方法：遵循中医骨伤动静结合、筋骨并重、内外兼治、医患合作之原则,采用中药、针灸、体疗方式进行综合治疗。结果：41例中,27例30天痊愈;9例40天痊愈：5例50天痊愈。结论：中药、针灸结合体疗对第五跖骨基底部骨折有良好的疗效。     

Comparison between specified percentage and fifth percentile criteria for spirometry interpretation in Thai patients

OBJECTIVES: The present study was conducted to determine the degree of agreement between the interpretation of spirometry using a specified percentage of predicted value (SPC) and the fifth percentile (FPC) as the cut off between normal and abnormal. METHODOLOGY: Spirometric values were collected for 1754 subjects attending the respiratory service at Siriraj Hospital between February 2000 and April 2001. These values included forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, maximal mid-expiratory flow (FEF25-75%) and peak expiratory flow (PEF). A comparison of results between SPC and FPC was performed. The SPC cut-off values for FVC, FEV1, FEV1/FVC, FEF25-75% and PEF were 80% predicted, 80% predicted, 70%, 65% predicted and 80% predicted, respectively. The FPC cut-off values were calculated from reference equations for the Thai population. Inter-rater agreement was calculated as the kappa score. RESULTS: High kappa scores were obtained for FVC (0.84), FEV1 (0.88) and FEF25-75% (0.80). However, poor agreement was found for FEV1/FVC (0.72) and PEF (0.61). When the cut-off values for SPC were modified to 90% of predicted values for FEV1/FVC and to 65% of predicted values for PEF, agreement was substantially improved to 0.92 and 0.89, respectively. CONCLUSIONS: Interpretation by SPC using cut-off values of 80% predicted for FVC and FEV1 and 65% predicted for FEF25-75% resulted in good agreement with FPC. However, the SPC cut-off values for FEV1/FVC and PEF should be modified to 90% predicted and 65% predicted, respectively.     

在患者脑脊液中同时查见广州管圆线虫第V期幼虫与发育期雌性成虫

目的 :为诊治广州管圆线虫病寻找可靠的虫种鉴定依据。方法 :镜检脑脊液 ,鉴定虫种、测量虫体及嗜酸性粒细胞计数。结果 :首次在患者脑脊液中同时查见 2条不同发育期的广州管圆线虫。结论 :为临床确诊广州管圆线虫病提供经验 ,并为该病的早期诊治提供可靠的病原学依据。