山东省社区空巢老人社会支持与自理能力现状及关联研究

目的 探讨城市社区空巢老人社会支持与自理能力现状,并分析社会支持对空巢老人自理能力的影响。方法 采取多阶段分层随机抽样方法,抽取山东省城市社区卫生服务机构的2597名空巢老人作为研究对象,采用自编一般资料调查表、社会支持评定量表（SSRS）、日常生活活动能力量表（ADL）进行调查。结果 山东省社区空巢老人社会支持评分为低、中水平占97.2%,ADL受损者占74.1%;社会支持总评分（r=-0.137,P＜0.01）及其主观支持（r=-0.150,P＜0.01）、客观支持（r=-0.086,P＜0.01）维度与日常生活活动能力呈负相关;回归结果显示,不同性别、年龄、婚姻状况、文化程度、患慢性病情况、两周患病情况、社会支持是ADL的影响因素,差异具有统计学意义（P＜0.05）。结论 社区空巢老人自理能力较差,社会支持水平较低,社会支持与空巢老人自理能力呈负相关。通过“政府-社区-家庭”支持系统加强对空巢老人的社会支持,提升老年人自我照顾能力,提高其生活质量。     

空蝶鞍综合征20例的临床和MRI分析

分析２０例空蝶鞍综合征（ＥＳＳ）的ＭＲＩ表现和其中１６例的内分泌改变。结果１６例ＥＳＳ均有内分泌功能异常。ＭＲＩ表现有蝶鞍充满长Ｔ＿１和长Ｔ＿２的脑脊液;垂体受压至鞍底,冠状位呈“锚”状,矢状位呈“新月”状;垂体柄延长。结果表明ＥＳＳ常具有内分泌功能紊乱,ＭＲＩ对ＥＳＳ具有特征性诊断意义。     

Hormone levels of follicular fluids with and without oocytes in patients who received gonadotropin-releasing hormone analogues and gonadotropins in an in vitro fertilization program

Background Are follicles where no oocytes are retrieved empty follicles?Methods The levels of estradiol (E₂), progesterone (P), testosterone (T), cortisol (F), and prolactin (PRL) of follicular fluids (FF) aspirated individually from 34 randomly selected IVF patients in whom no oocytes were recovered were compared with the respective hormone levels of FF obtained from the same patients when oocytes were retrieved. Two FF without oocytes of a 35th patient in whom no oocytes were retrieved were analyzed.Results Hormones did not differ significantly in the paired samples, while in the two FF of the 35th woman they were in agreement with cystic follicles.Conclusions It is necessary to differentiate aspirated follicles where no oocytes are retrieved from the empty follicle syndrome, which was not observed in the IVF series studied and should be rare in IVF patients.     

探索基于码头完全信息化的空箱码头查验模式

目的大力推进码头信息化建设,分析和探索先进的进境集装箱空箱检疫模式,以完善空箱检疫机制,有效防范疫病疫情和有毒有害物质传播入境。方法借鉴国内外先进口岸的进境集装箱空箱检疫模式和码头信息化建设,分析现有模式的弊端及工作中存在的问题,探讨进境空箱的检疫风险,研究进境空箱检疫新模式及与之配套的口岸码头信息化建设。结果进境集装箱空箱检疫风险较大且复杂,现有的堆场查验模式常出现漏检现象,码头信息化管理落后,无法将检关港高效有序协调起来,大大降低了工作效率和服务质量。结论现有进境集装箱空箱检疫模式存在的问题不容忽视,需积极推进口岸码头的信息化建设,并在此基础上积极稳妥地探索和实践空箱检疫码头查验新模式。     

空管用药与根管充填治疗儿童乳牙牙髓炎的疗效差异

目的:探究空管用药与根管充填治疗儿童乳牙牙髓炎的疗效差异。方法:选择某院于2016年~2018年收治的60例乳牙牙髓炎患儿,按照治疗方式不同将其分为观察组与对照组各30例。观察组患儿给予空管用药治疗手段,对照组患儿给予根管充填治疗,对比组间患儿治疗效果及治疗满意度。结果:观察组有效率为96.7%,对照组总有效率为70%,观察组治疗效果显著优于对照组,差异有统计学意义(P<0.05);观察组满意度为96.7%,对照组满意度为66.7%,观察组满意度明显高于对照组,差异有统计学意义(P<0.05)。结论:在儿童乳牙牙髓炎治疗过程中,空管用药治疗比根管充填治疗效果更为显著,能有效提升治疗满意度,同时操作相对简单,充分节省患儿与医师时间,值得临床推广与应用。     

空卵泡综合征患者家系的LHCGR基因突变检测及系谱分析

目的 探究促黄体生成素/绒毛膜促性腺激素受体(LHCGR)基因突变与空卵泡综合征(EFS)的关系,指导相关生殖疾病的诊治。方法 通过基因测序对一例EFS的不孕症患者进行LHCGR基因突变和家系分析。结果 该患者LHCGR 基因第11 外显子处存在纯合突变:chr2:48915113A>G,c.1823T>C,p.Leu608Pro,突变使LHCGR 蛋白在第 608 位由亮氨酸(Leucine, Leu)突变为脯氨酸(Proline ,Pro)。对该患者进行家系分析并对其家庭成员测序发现,父母在此位点属于杂合突变,先证者弟弟(46,XY。未育)属于纯合突变,先证者妹妹(育有一女孩、一男孩)属于杂合突变。结论 LHCGR基因突变可导致EFS,进而导致相关生殖疾病的发生。     

湖南省贫困县农村空巢老人互助养老意愿及影响因素研究

目的了解湖南省贫困县农村空巢老人的互助养老意愿、需求及影响因素,为农村互助养老的发展定位及对策研究提供参考。方法采用分层随机整群抽样的方法选择湖南省安仁县5个乡镇50个行政村的807名空巢老人,采用自制互助养老意愿及需求问卷、社会支持评定量表、健康促进生活方式量表进行调查。结果 272人(33.71%)选择愿意接受互助养老,互助养老需求评分为3.22±0.63。Logistic回归分析显示:贫困县农村空巢老人互助养老意愿受年龄、文化程度、自理能力、目前患慢性病数量、健康促进生活方式5个因素的影响(均P0.01)。结论贫困县农村空巢老人的互助养老意愿不强,对健康服务需求较高,高龄、文化程度高、自理能力差、患慢性病数量多、健康促进生活方式水平低的农村空巢老年人互助养老意愿相对较高。需提高农村空巢老人对互助养老的认知,以促进农村养老的健康发展。     

CT引导下空针导航联合平静呼吸法在肺亚厘米结节穿刺活检中的应用价值

 目的 探讨CT引导下空针导航联合平静呼吸法在穿刺活检肺亚厘米结节的应用价值。方法 选取2016-05至2018-10武警四川总队医院放射科诊断的肺亚厘米结节(≤1 cm)患者63例,在 CT引导下应用空针导航联合平静呼吸法进行穿刺取材,统计分析穿刺活检成功率、术后相关并发症及术后病理诊断结果。结果 空针导航联合平静呼吸法穿刺活检成功率为98.4%(62/63);术后气胸发生率20.6%(13/63),术后出血发生率31.7%(20/63);病例随访中均未发现感染或肿瘤播散转移等。成功穿刺活检的62例中:鳞癌4例,腺癌21例(原位腺癌3例),转移癌2例,恶性黑色素瘤1例;慢性炎性反应19例,肉芽肿性炎7例,粉尘沉着伴淋巴细胞增生5例,肺泡上皮增生2例,真菌1例。结论 对肺亚厘米结节患者采用空针导航联合平静呼吸法进行穿刺活检安全可靠且成功率高,是诊断早期肺癌的重要手段。     

Time Interval of Two Injections and First-Dose Dependent of Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomal Gambogenic Acid: The Contribution of PEG-Specific IgM

Repeated injection of PEGylated liposomes can cause the disappearance of long circulating property because of the induction of anti-PEG IgM antibody referred to as “accelerated blood clearance (ABC) phenomenon.” Although ABC phenomenon typically occurs when entrapped drugs are chemotherapeutic agent with low cytotoxic, there is little evidence of accelerated blood clearance of PEGylated herbal-derived compound on repeated injection. Herein, we investigated the blood concentration of PEGylated liposomal gambogenic acid (PEG-GEA-L), a model PEGylated liposomal herbal extract, on its repeated injection to rats. We found time interval between injections had considerable impact on the magnitude of ABC phenomenon induced by PEG-GEA-L. When time interval was prolonged from 3 days to 7 days, ABC phenomenon could be attenuated. Furthermore, its magnitude was enhanced accompanied by a marked rise in the accumulation of PEG-GEA-L in the liver and spleen in a first-dose–dependent manner. Consistently, the level of anti-PEG IgM significantly increased with the first dose of PEG-GEA-L and decreased with the extended time interval between injections, which implies anti-PEG IgM is a major contributor to the ABC phenomenon. Notably, the increased expression of liver anti-PEG IgM was accompanied by an increased expression of efflux transporters in the induction process of the ABC phenomenon.