全文获取类型
收费全文 | 35228篇 |
免费 | 2779篇 |
国内免费 | 676篇 |
专业分类
耳鼻咽喉 | 235篇 |
儿科学 | 421篇 |
妇产科学 | 413篇 |
基础医学 | 2003篇 |
口腔科学 | 1237篇 |
临床医学 | 5180篇 |
内科学 | 8704篇 |
皮肤病学 | 6186篇 |
神经病学 | 699篇 |
特种医学 | 1711篇 |
外国民族医学 | 4篇 |
外科学 | 3760篇 |
综合类 | 3043篇 |
一般理论 | 1篇 |
预防医学 | 1254篇 |
眼科学 | 1086篇 |
药学 | 1322篇 |
12篇 | |
中国医学 | 225篇 |
肿瘤学 | 1187篇 |
出版年
2024年 | 63篇 |
2023年 | 617篇 |
2022年 | 862篇 |
2021年 | 1412篇 |
2020年 | 1318篇 |
2019年 | 1268篇 |
2018年 | 1257篇 |
2017年 | 1280篇 |
2016年 | 1320篇 |
2015年 | 1295篇 |
2014年 | 2233篇 |
2013年 | 2242篇 |
2012年 | 1803篇 |
2011年 | 1872篇 |
2010年 | 1525篇 |
2009年 | 1635篇 |
2008年 | 1559篇 |
2007年 | 1575篇 |
2006年 | 1455篇 |
2005年 | 1270篇 |
2004年 | 1194篇 |
2003年 | 1007篇 |
2002年 | 833篇 |
2001年 | 799篇 |
2000年 | 534篇 |
1999年 | 618篇 |
1998年 | 656篇 |
1997年 | 545篇 |
1996年 | 553篇 |
1995年 | 475篇 |
1994年 | 459篇 |
1993年 | 419篇 |
1992年 | 349篇 |
1991年 | 324篇 |
1990年 | 244篇 |
1989年 | 311篇 |
1988年 | 306篇 |
1987年 | 195篇 |
1986年 | 151篇 |
1985年 | 166篇 |
1984年 | 117篇 |
1983年 | 91篇 |
1982年 | 87篇 |
1981年 | 72篇 |
1980年 | 82篇 |
1979年 | 35篇 |
1978年 | 49篇 |
1977年 | 42篇 |
1976年 | 41篇 |
1975年 | 45篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
《Journal of cranio-maxillo-facial surgery》2022,50(3):225-229
The aim of this study was to investigate the clinical course of masticatory function recovery following arthrocentesis. Patients with a unilateral condylar head fracture who underwent arthrocentesis for therapeutic reasons were evaluated and compared with patients with a unilateral condylar head fracture who did not undergo arthrocentesis. At 3 months after treatment, the occlusal contact area and maximum bite force in patients with a fracture treated with arthrocentesis were greater than in those who did not receive arthrocentesis at the same time points, although the differences were not significant. Moreover, at 1 and 3 months following arthrocentesis, mean (±SD) occlusal contact area (1 month: 1.99 ± 0.55 mm2, p = 0.01; 3 months: 2.90 ± 1.36 mm2, p = 0.03) and maximum bite force (1 month: 82.45 ± 15.04 N, p = 0.01; 3 months: 101.11 ± 14.53 N, p = 0.01) on the fractured side in patients who underwent that treatment were significantly reduced when compared with those on the non-fractured side. The authors conclude that if the priority is to avoid open reduction and internal fixation, then the arthrocentesis approach might be a less invasive alternative, albeit with the price of a prolonged healing interval. 相似文献
2.
Hyperosmotic tear stimulates human corneal nerve endings, activates ocular immune response, and elicits dry-eye symptoms. A soft contact lens (SCL) covers the cornea preventing it from experiencing direct tear evaporation and the resulting blink-periodic salinity increases. For the cornea to experience hyperosmolarity due to tear evaporation, salt must transport across the SCL to the post-lens tear film (PoLTF) bathing the cornea. Consequently, limited salt transport across a SCL potentially protects the ocular surface from hyperosmotic tear. In addition, despite lens-wear discomfort sharing common sensations to dry eye, no correlation is available between measured tear hyperosmolarity and SCL-wear discomfort. Lack of documentation is likely because clinical measurements of tear osmolarity during lens wear do not interrogate the tear osmolarity of the PoLTF that actually overlays the cornea. Rather, tear osmolarity is clinically measured in the tear meniscus. For the first time, we mathematically quantify tear osmolarity in the PoLTF and show that it differs significantly from the clinically measured tear-meniscus osmolarity. We show further that aqueous-deficient dry eye and evaporative dry eye both exacerbate the hyperosmolarity of the PoLTF. Nevertheless, depending on lens salt-transport properties (i.e., diffusivity, partition coefficient, and thickness), a SCL can indeed protect against corneal hyperosmolarity by reducing PoLTF salinity to below that of the ocular surface during no-lens wear. Importantly, PoLTF osmolarity for dry-eye patients can be reduced to that of normal eyes with no-lens wear provided that the lens exhibits a low lens-salt diffusivity. Infrequent blinking increases PoLTF osmolarity consistent with lens-wear discomfort. Judicious design of SCL material salt-transport properties can ameliorate corneal hyperosmolarity. Our results confirm the importance of PoLTF osmolarity during SCL wear and indicate a possible relation between PoLTF osmolarity and contact-lens discomfort. 相似文献
3.
Kevin Kyung Ho Choi Santosh Sanagapalli 《World journal of gastrointestinal oncology》2022,14(3):568-586
Barrett's esophagus (BE) is the precursor to esophageal adenocarcinoma (EAC). Progression to cancer typically occurs in a stepwise fashion through worsening dysplasia and ultimately, invasive neoplasia. Established EAC with deep involvement of the esophageal wall and/or metastatic disease is invariably associated with poor long-term survival rates. This guides the rationale of surveillance of Barrett’s in an attempt to treat lesions at an earlier, and potentially curative stage. The last two decades have seen a paradigm shift in management of Barrett’s with rapid expansion in the role of endoscopic eradication therapy (EET) for management of dysplastic and early neoplastic BE, and there have been substantial changes to international consensus guidelines for management of early BE based on evolving evidence. This review aims to assist the physician in the therapeutic decision-making process with patients by comprehensive review and summary of literature surrounding natural history of Barrett’s by histological stage, and the effectiveness of interventions in attenuating the risk posed by its natural history. Key findings were as follows. Non-dysplastic Barrett’s is associated with extremely low risk of progression, and interventions cannot be justified. The annual risk of cancer progression in low grade dysplasia is between 1%-3%; EET can be offered though evidence for its benefit remains confined to highly select settings. High-grade dysplasia progresses to cancer in 5%-10% per year; EET is similarly effective to and less morbid than surgery and should be routinely performed for this indication. Risk of nodal metastases in intramucosal cancer is 2%-4%, which is comparable to operative mortality rate, so EET is usually preferred. Submucosal cancer is associated with nodal metastases in 14%-41% hence surgery remains standard of care, except for select situations. 相似文献
4.
5.
Brittney H. Cotta Margaret F. Meagher Aaron Bradshaw Stephen T. Ryan Gerant Rivera-Sanfeliz 《Expert review of anticancer therapy》2019,19(4):301-308
Introduction: Percutaneous renal mass biopsy has evolved over the last decade with improvements on previous pitfalls including low tissue yield, high non-diagnostic rates, and complications. As understanding of tumor biology and natural history of renal cortical neoplasms has improved, percutaneous renal mass biopsy is poised to have an expanding role in an area characterized by individualized management and refined risk stratification.
Areas covered: This review summarizes the evolution of renal mass biopsy to its current state with respect to outcomes, indications, and clinical guidelines.
Expert opinion: With improved understanding of differential biological potential of renal cortical neoplasms combined with technical improvements in diagnostic yield and accuracy, utilization of renal mass biopsy is becoming an important adjunct to patient care in a broad range of clinical scenarios, including active surveillance, thermal ablation, and use of primary systemic therapy in localized and advanced settings. 相似文献
6.
7.
全膝关节置换术是目前治疗终末期膝关节骨性关节炎最有效的方法之一,全膝关节置换术后膝关节功能、术后膝关节疼痛与术后下肢力线有着密切的关系。目前膝关节置换术下肢对线方式主要采用机械力学对线方法,该方法可以改善膝关节功能,但是有部分患者也会产生术后膝关节的疼痛、活动受限等并发症,导致术后患者满意度较差。近些年越来越多的研究开始关注运动力学对线技术并应用于临床。运动学对线技术旨在重建患者的解剖结构,将膝关节假体运动轴与膝关节生理性运动轴保持一致,减少膝关节周围软组织和韧带的松解,实现膝关节生理性运动。该文就运动力学对线方法在全膝关节置换术中的应用进展作一综述。 相似文献
8.
《Foot and Ankle Surgery》2022,28(8):1468-1472
BackgroundThe surgical treatment for osteoid osteoma (OO) in the foot and ankle is challenging. It is difficult to locate the lesion and the anatomy is crowded by sensitive structures. The purpose of this study was to describe the outcomes of navigated mini open-intralesional curettage (NMIC) or navigated minimally invasive radiofrequency ablation (NMRFA) in treating these lesions.MethodsAll patients who underwent surgery for OO in the foot and ankle between 2015 and 2020 were included. O-arm navigation was used in All procedures. The choice of NMIC versus NMRFA was made by the surgeon according to the location of the lesion and its proximity to sensitive anatomic structures.ResultsFourteen patients were included. Ten were operated by NMRFA and 4 by NMIC. All patients’ symptoms related to OO resolved following a single procedure. Average AOFAS score increased by 18.7 (P < .001). Three patients had the following complications: pathologic fracture, superficial infection and transient deep peroneal nerve sensory loss.ConclusionNavigated surgical treatment of OO in the foot and ankle is accurate, efficient and safe. 相似文献
9.
目的 评价调整光学切削直径及Kappa角后对准分子激光原位角膜磨镶术(laser in situ keratomileusis,LASIK)后效果的影响。方法 选取2017年1月至12月在我院行LASIK手术的高度近视患者313例(626眼),根据切削直径分成两组,试验组157例314眼,切削直径设定为6.0 mm,对照组156例312眼,切削直径设定为6.5 mm。试验组患者激光切削前修正Kappa角,对照组不做修正。患者术前进行裸眼视力、主视眼确定、验光、眼压、暗室下瞳孔直径、泪液分泌试验、裂隙灯、散瞳验光、眼底检查、pentacam测量角膜厚度、角膜地形图测量角膜前后表面及Kappa角等检查。术后1 d、1周、1个月随访,并检查裸眼视力、角膜厚度、波前像差及夜间视力、光晕、眩光等情况。比较两组患者角膜厚度变化、手术所用时间以及两组患者术后的高阶像差的差异。结果 试验组与对照组患者年龄分别为18~44(24.19±5.33)岁、18~42(25.08±4.91)岁,屈光度分别为(-7.47±1.04)D、(-7.61±1.12)D。两组年龄、屈光度比较差异均无统计学意义(均为P>0.05)。试验组与对照组患者术前Kappa角分别为,X轴:(210±40)μm、(200±30)μm,Y轴:(190±30)μm、(220±40)μm,差异无统计学意义(P=0.210)。两组手术前后的角膜厚度及术后角膜基质床的厚度差异均无统计学意义(均为P>0.05)。试验组与对照组的手术时间分别为(15.56±1.89)s和(20.83±3.03)s,差异有统计学意义(P=0.000)。试验组的总高阶像差和垂直慧差的变化均明显低于对照组(均为 P<0.01),但两组间的水平慧差差异无统计学意义(P>0.05),对照组的球差低于试验组(P<0.01)。结论 LASIK手术中科学合理地调整Kappa角可有助于提高患者术后的视觉质量。 相似文献
10.
Sharada Sivaram Kalavakolanu 《Journal of the Saudi Heart Association》2015,27(3):206-209
We report a case of a young male presenting as Restrictive cardiomyopathy, refractory heart failure and syncope due to typical right atrial flutter complicating hypertrophic cardiomyopathy.Successful catheter ablation of the flutter promptly ameliorated the congestive failure with resolution of restrictive physiology. 相似文献