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《Clinical Lymphoma, Myeloma & Leukemia》2022,22(8):608-617
BackgroundConsiderable progress has been made in therapeutic options for multiple myeloma (MM). Understanding the current landscape of MM treatment options and associated outcomes in the real world is important in providing key insights into clinical and knowledge gaps which could be targeted for further optimization.MethodsThe Canadian Myeloma Research Group Database (CMRG-DB) is a prospectively maintained disease-specific database with >7000 patients. The objective of this study was to describe the trends in the treatment landscape and outcomes including early mortality, time to next treatment, and overall survival (OS) in each line of treatment stratified by autologous stem cell transplant (ASCT) receipt among newly-diagnosed MM patients in Canada between 2007 and 2018.ResultsA total of 5154 patients were identified among which 3030 patients (58.8%) received an upfront ASCT and 2124 (41.2%) did not. At diagnosis, the median age was 64 years and 58.6% were males. Bortezomib and lenalidomide were most frequently used (>50%) in first and second-line treatment respectively among both the ASCT and non-ASCT cohort. The median OS was 122.0 months (95% Cl 115.0-135.0 months) and 54.3 months (95% CI 50.8-58.8 months) for the ASCT and non-ASCT cohort respectively with an incremental decrease in OS in each subsequent line of treatment.ConclusionWe present the largest study to date in the Canadian landscape showing the characteristics, therapy usage, and outcomes among MM patients. This information will be critical in benchmarking current outcomes and provide key insight into areas of unmet needs and gaps for improvement of MM patients nationally. 相似文献
3.
目的 分析2005 - 2014年我国老年人肺癌发病的时间趋势,为我国肺癌的防控工作提供依据。方法 根据2008 - 2017年《中国肿瘤登记年报》中肺癌的相关数据,分析2005 - 2014年我国老年人肺癌的发病情况,并通过年度变化百分比(annual percentage change,APC)分析其时间变化趋势。结果 2005 - 2014年我国老年人肺癌的发病率呈上升趋势(APC = 0.71%,P<0.05),其中农村老年人肺癌的发病率从198.9/105上升至250.7/105,上升趋势更明显(APC = 2.81%,P<0.05),尤以农村老年女性肺癌发病率的上升趋势最为明显(APC = 5.26%,P<0.05)。2005 - 2014年中国老年人肺癌的发病在60~64岁和65~69岁组呈上升趋势(APC分别为2.83%和2.04%,均P<0.05),而在农村地区,老年人所有年龄组的肺癌发病率都呈明显上升趋势(APC分别为3.49%,3.86%,1.66%,2.31%,3.49%及6.37%,均P<0.05)。结论 2005 - 2014年我国老年人肺癌发病上升趋势明显,以农村老年女性最为突出,国家应针对高危人群及早开展筛查等工作,降低我国老年人肺癌的流行水平。 相似文献
4.
Luis Miguel Azogil-López Juan José Pérez-Lázaro Patricia Ávila-Pecci Esther María Medrano-Sánchez María Valle Coronado-Vázquez 《Atencion primaria / Sociedad Espa?ola de Medicina de Familia y Comunitaria》2019,51(5):278-284
Aim
The purpose of this study is to find out whether telephone referral from Primary Health Care to Internal Medicine Consult manages to reduce waiting days as compared to traditional referral. This study also aims to know how acceptable is the telephone referral to general practitioners and their patients.Design
No blind randomized controlled clinical trial.Setting
Northern Huelva Health District.Participants
154 patients.Interventions
Patients referrals from intervention clinicians were sent via telephone consultation, whereas patients referrals from control clinicians were sent by traditional via.Measurements
Number of days from referral request to Internal Medicine Consult. Number of telephone and traditional referrals. Number of doctors and patients denied. Denial reasons.Results
A statistically significant difference was found between groups, with an average of 27 (21-34) days. Among General Practitioners, 8 of the first 58 total doctors after randomization and, subsequently, 6 of the 20 doctors of the test group refused to engage in the trial because they considered “excessive time and effort consuming”. 50% of patients referred by the 14 General Practitioners finally randomized to the intervention group were denied referral by telephone due to patient's complexity.Conclusions
Telephone referral significantly reduces waiting days for Internal Medicine consult. This type of referral did not mean an “excessive time and effort consuming” to General Practitioners and was not all that beneficial to complex patients 相似文献5.
6.
手术患者“边缘时间”的安全护理 总被引:7,自引:0,他引:7
现代医院手术室每日接待大量的手术患者,虽然都已经认识到各种风险的存在,但往往把目光集中在手术间内,而容易忽略手术前、后病人在转运过程“边缘时间”的安全。文章总结、分析了以往手术前后“边缘时间”存在的风险,设置了合理的接送程序;使用患者身份识别腕带的“五查对制度”;采取搬运患者前的“一查、二看、三整理、四搬运”等护理对策。 相似文献
7.
血液标本放置时间和抗凝剂对血糖检测结果的影响 总被引:5,自引:0,他引:5
目的 :探讨两种抗凝剂的血液标本放置时间对血糖测定的影响。方法 :采集门诊健康人血液标本 30份 ,分别以肝素钠和氟化钠作抗凝 ,放置不同时间检测血糖值。结果 :及时分离血浆的血液标本血糖在 5h内差异无显著性。而血液离体后不及时分离血浆 ,血糖是随着时间延长而降低。氟化钠抗凝的血糖比肝素钠抗凝的血糖下降的程度要缓慢一些 ,所以临床上采集血液标本必须及时分离血浆 ,选用合适的抗凝剂 ,及时测定 ,减少误差 ,提高准确性 ,给临床提供准确的诊断依据 相似文献
8.
PET/CT图像采集时间对图像质量和病灶检出率的影响 总被引:1,自引:0,他引:1
目的探讨在不影响图像质量和病灶检出率前提下缩短PET/CT图像采集时间的可行性。方法18例接受PET/CT检查的患者,在CT扫描后按1、2、3min/床位依次进行3次PET扫描,共得到54帧图像。患者按体重分为以下3组:(1)45~60kg(7例),(2)61~75kg(7例),(3)76~90k(4例)。由2位有经验的医师共同阅片确定每例患者病变的位置和数目,图像质量由2位医师独立判断。结果3min/床位PET/CT图像上共检出127个病灶,其中最小的病灶直径约为3mm,除1min/床位图像漏检3个病灶外,其他所有病灶均能被1min/床位、2min/床位的图像识别。(1)~(3)组患者在3min/床位采集图像上识别的病灶数分别为71、41、15个,第1组患者的所有病灶在3种不同采集时间图像上均能被识别,第2组患者1min/床位采集图像遗漏了3个病灶,而2min/床位图像识别出的病灶数与3min/床位图像相同。第3组患者的所有病灶在3种采集图像上也均能被识别。1、2min/床位的PET图像质量均较3min/床位图像差,1min/床位图像质量最差,主要表现为图像本底噪声高、对比度差。3组患者中,第3组患者图像质量最差。结论对体重低于60瞻患者,1~3min的采集时间,病变的检出率无明显差异;而对体重60k以上患者,建议选择2~3min/床位的采集时间,对病情较重或不合作患者,根据需要可考虑选择1min/床位的采集时间。 相似文献
9.
Summary Methods in current practice for ascertaining time of death are largely based on the cooling of the body after death and are
somewhat unreliable. A theoretica relationship is known to exist between the decline in the properties defining nerve conduction
and time after death caused by the gradual cessation of metabolic activity in nerves. A number of such properties were measured
in rats during life and after death. In most cases the relationship was found to be inconsistent. The chronaxie of the strength
duration curve for the sciatic nerve was, however, found to increase consistently and reproducibly in a linear fashion over
the first 90 min after death to a plateau value which was maintained beyond 135 min. These findings are discussed as the possible
basis of a forensic method of determining the duration of the “post mortem interval” within the first few hours after death.
相似文献
10.
M. K. Watson L. S. Jakobson 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1997,117(2):273-280
In the present study, a kinematic analysis was made of unconstrained, natural prehension movements directed toward an object
approaching the observer on a conveyor belt at one of three constant velocities, from one of three different directions (head-on
or along the fronto-parallel plane coming either from the subject′s left or right). Subjects were required to grasp the object
when it reached a target located 20 cm directly in front of the hand′s start position. The kinematic analysis revealed that
both the transport and grasp components of the movement changed in response to the experimental manipulations, but did so
in a manner that guaranteed that, for objects approaching from a given direction, hand closure would begin at a constant time
prior to object contact (regardless of the object’s approach speed). The kinematic analysis also revealed, however, that the
onset of hand closure began earlier with objects approaching from the right than from other directions – an effect which would
not be predicted if time to contact was the key variable controlling the onset of hand closure. These results, then, lend
only partial support to the theory that temporal coordination between the transport and grasp components of prehension is
ensured through their common dependence on time to contact information.
Received: 20 September 1996 / Accepted: 16 June 1997 相似文献