全文获取类型
收费全文 | 25925篇 |
免费 | 1776篇 |
国内免费 | 600篇 |
专业分类
耳鼻咽喉 | 194篇 |
儿科学 | 433篇 |
妇产科学 | 625篇 |
基础医学 | 803篇 |
口腔科学 | 122篇 |
临床医学 | 6433篇 |
内科学 | 7430篇 |
皮肤病学 | 82篇 |
神经病学 | 328篇 |
特种医学 | 2356篇 |
外国民族医学 | 2篇 |
外科学 | 3120篇 |
综合类 | 3201篇 |
预防医学 | 608篇 |
眼科学 | 239篇 |
药学 | 900篇 |
11篇 | |
中国医学 | 143篇 |
肿瘤学 | 1271篇 |
出版年
2024年 | 63篇 |
2023年 | 515篇 |
2022年 | 842篇 |
2021年 | 1182篇 |
2020年 | 1125篇 |
2019年 | 1101篇 |
2018年 | 1036篇 |
2017年 | 1019篇 |
2016年 | 873篇 |
2015年 | 925篇 |
2014年 | 1854篇 |
2013年 | 1729篇 |
2012年 | 1397篇 |
2011年 | 1451篇 |
2010年 | 1214篇 |
2009年 | 1284篇 |
2008年 | 1273篇 |
2007年 | 1206篇 |
2006年 | 1238篇 |
2005年 | 1010篇 |
2004年 | 855篇 |
2003年 | 698篇 |
2002年 | 547篇 |
2001年 | 493篇 |
2000年 | 408篇 |
1999年 | 364篇 |
1998年 | 331篇 |
1997年 | 305篇 |
1996年 | 241篇 |
1995年 | 202篇 |
1994年 | 198篇 |
1993年 | 143篇 |
1992年 | 124篇 |
1991年 | 113篇 |
1990年 | 69篇 |
1989年 | 92篇 |
1988年 | 67篇 |
1987年 | 61篇 |
1986年 | 74篇 |
1985年 | 67篇 |
1984年 | 45篇 |
1983年 | 50篇 |
1982年 | 77篇 |
1981年 | 67篇 |
1980年 | 36篇 |
1979年 | 36篇 |
1978年 | 65篇 |
1977年 | 27篇 |
1976年 | 45篇 |
1974年 | 23篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Kevin Kyung Ho Choi Santosh Sanagapalli 《World journal of gastrointestinal oncology》2022,14(3):568-586
Barrett's esophagus (BE) is the precursor to esophageal adenocarcinoma (EAC). Progression to cancer typically occurs in a stepwise fashion through worsening dysplasia and ultimately, invasive neoplasia. Established EAC with deep involvement of the esophageal wall and/or metastatic disease is invariably associated with poor long-term survival rates. This guides the rationale of surveillance of Barrett’s in an attempt to treat lesions at an earlier, and potentially curative stage. The last two decades have seen a paradigm shift in management of Barrett’s with rapid expansion in the role of endoscopic eradication therapy (EET) for management of dysplastic and early neoplastic BE, and there have been substantial changes to international consensus guidelines for management of early BE based on evolving evidence. This review aims to assist the physician in the therapeutic decision-making process with patients by comprehensive review and summary of literature surrounding natural history of Barrett’s by histological stage, and the effectiveness of interventions in attenuating the risk posed by its natural history. Key findings were as follows. Non-dysplastic Barrett’s is associated with extremely low risk of progression, and interventions cannot be justified. The annual risk of cancer progression in low grade dysplasia is between 1%-3%; EET can be offered though evidence for its benefit remains confined to highly select settings. High-grade dysplasia progresses to cancer in 5%-10% per year; EET is similarly effective to and less morbid than surgery and should be routinely performed for this indication. Risk of nodal metastases in intramucosal cancer is 2%-4%, which is comparable to operative mortality rate, so EET is usually preferred. Submucosal cancer is associated with nodal metastases in 14%-41% hence surgery remains standard of care, except for select situations. 相似文献
2.
3.
Brittney H. Cotta Margaret F. Meagher Aaron Bradshaw Stephen T. Ryan Gerant Rivera-Sanfeliz 《Expert review of anticancer therapy》2019,19(4):301-308
Introduction: Percutaneous renal mass biopsy has evolved over the last decade with improvements on previous pitfalls including low tissue yield, high non-diagnostic rates, and complications. As understanding of tumor biology and natural history of renal cortical neoplasms has improved, percutaneous renal mass biopsy is poised to have an expanding role in an area characterized by individualized management and refined risk stratification.
Areas covered: This review summarizes the evolution of renal mass biopsy to its current state with respect to outcomes, indications, and clinical guidelines.
Expert opinion: With improved understanding of differential biological potential of renal cortical neoplasms combined with technical improvements in diagnostic yield and accuracy, utilization of renal mass biopsy is becoming an important adjunct to patient care in a broad range of clinical scenarios, including active surveillance, thermal ablation, and use of primary systemic therapy in localized and advanced settings. 相似文献
4.
5.
Itay Zmora Yonit Wiener-Well Evan Avraham Alpert 《The American journal of emergency medicine》2019,37(5):1006.e5-1006.e7
Background
Purulent bacterial pericarditis is a rare and potentially fatal disease. The course may be fulminant, and the presentation may pose a diagnostic challenge.Case report
An otherwise healthy 75-year-old male was brought to the emergency department in a state of general deterioration, confusion, and shock. Bedside ultrasound showed a significant pericardial effusion. His condition quickly deteriorated and the resuscitation included emergent bedside pericardiocentesis. The drainage was purulent and later cultures grew out Streptococcus pneumoniae.Why should an emergency physician be aware of this?
Purulent pericarditis is extremely rare but should be considered in the patient with a fulminant infectious process (particularly pneumonia) and signs of pericardial effusion. Treatment should include appropriate antibiotics and early drainage. 相似文献6.
《Foot and Ankle Surgery》2022,28(8):1468-1472
BackgroundThe surgical treatment for osteoid osteoma (OO) in the foot and ankle is challenging. It is difficult to locate the lesion and the anatomy is crowded by sensitive structures. The purpose of this study was to describe the outcomes of navigated mini open-intralesional curettage (NMIC) or navigated minimally invasive radiofrequency ablation (NMRFA) in treating these lesions.MethodsAll patients who underwent surgery for OO in the foot and ankle between 2015 and 2020 were included. O-arm navigation was used in All procedures. The choice of NMIC versus NMRFA was made by the surgeon according to the location of the lesion and its proximity to sensitive anatomic structures.ResultsFourteen patients were included. Ten were operated by NMRFA and 4 by NMIC. All patients’ symptoms related to OO resolved following a single procedure. Average AOFAS score increased by 18.7 (P < .001). Three patients had the following complications: pathologic fracture, superficial infection and transient deep peroneal nerve sensory loss.ConclusionNavigated surgical treatment of OO in the foot and ankle is accurate, efficient and safe. 相似文献
7.
目的 评价调整光学切削直径及Kappa角后对准分子激光原位角膜磨镶术(laser in situ keratomileusis,LASIK)后效果的影响。方法 选取2017年1月至12月在我院行LASIK手术的高度近视患者313例(626眼),根据切削直径分成两组,试验组157例314眼,切削直径设定为6.0 mm,对照组156例312眼,切削直径设定为6.5 mm。试验组患者激光切削前修正Kappa角,对照组不做修正。患者术前进行裸眼视力、主视眼确定、验光、眼压、暗室下瞳孔直径、泪液分泌试验、裂隙灯、散瞳验光、眼底检查、pentacam测量角膜厚度、角膜地形图测量角膜前后表面及Kappa角等检查。术后1 d、1周、1个月随访,并检查裸眼视力、角膜厚度、波前像差及夜间视力、光晕、眩光等情况。比较两组患者角膜厚度变化、手术所用时间以及两组患者术后的高阶像差的差异。结果 试验组与对照组患者年龄分别为18~44(24.19±5.33)岁、18~42(25.08±4.91)岁,屈光度分别为(-7.47±1.04)D、(-7.61±1.12)D。两组年龄、屈光度比较差异均无统计学意义(均为P>0.05)。试验组与对照组患者术前Kappa角分别为,X轴:(210±40)μm、(200±30)μm,Y轴:(190±30)μm、(220±40)μm,差异无统计学意义(P=0.210)。两组手术前后的角膜厚度及术后角膜基质床的厚度差异均无统计学意义(均为P>0.05)。试验组与对照组的手术时间分别为(15.56±1.89)s和(20.83±3.03)s,差异有统计学意义(P=0.000)。试验组的总高阶像差和垂直慧差的变化均明显低于对照组(均为 P<0.01),但两组间的水平慧差差异无统计学意义(P>0.05),对照组的球差低于试验组(P<0.01)。结论 LASIK手术中科学合理地调整Kappa角可有助于提高患者术后的视觉质量。 相似文献
8.
Sharada Sivaram Kalavakolanu 《Journal of the Saudi Heart Association》2015,27(3):206-209
We report a case of a young male presenting as Restrictive cardiomyopathy, refractory heart failure and syncope due to typical right atrial flutter complicating hypertrophic cardiomyopathy.Successful catheter ablation of the flutter promptly ameliorated the congestive failure with resolution of restrictive physiology. 相似文献
9.
Evaluation of Adult versus Pediatric Transesophageal Echocardiography Probe Efficiency for Guiding Septal Puncture during Atrial Fibrillation Ablation
下载免费PDF全文
![点击此处可从《Echocardiography (Mount Kisco, N.Y.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
10.
Provocation of Atrial Fibrillation Triggers During Ablation: Does the Use of General Anesthesia Affect Inducibility?
下载免费PDF全文
![点击此处可从《Journal of cardiovascular electrophysiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)