Bipolar diathermy tonsillectomy

Tonsillectomy is an operation performed by various techniques. We have developed a bipolar diathermy dissection technique that allows a low intra-operative blood loss without an increase in complications. The average blood loss was less than 4 ml in 100 patients. Most were able to drink and eat by 4 and 10 hours respectively. There was no increase in analgesic requirements. No primary haemorrhage was recorded; three patients had a secondary haemorrhage. The technique allows accurate coagulation of blood vessel and is an easy procedure to learn.     

腹腔灌注联合射频透热治疗28例晚期卵巢癌

[目的]探讨晚期卵巢癌腹腔转移的治疗方法。[方法]以顺铂 卡铂 依托泊甙为主的联合方案行腹腔持续热灌注化疗并腹腔射频透热治疗28例晚期卵巢上皮癌，观察其疗效及毒副反应。[结果]完全缓解(CR)5例，部分缓解(PR)16例，稳定（NC）5例，进展（PD）2例，总有效率75.0%。主要毒副反应为骨髓抑制。[结论]双铂联合依托泊甙腹腔热灌注并射频透热治疗对中晚期卵巢癌疗效较好，毒副反应少。     

Impact of unilateral versus bilateral laparoscopic ovarian drilling on ovarian reserve and pregnancy rate: a randomized clinical trial

Objective: To assess the impact of unilateral dose adjusted ovarian drilling (ULOD) compared to bilateral ovarian drilling (BLOD) on ovarian reserve and pregnancy rate.

Methods: This randomized clinical study included 105 patients with polycystic ovary syndrome. Patients were assigned to two groups; group 1 (n?=?52) underwent dose adjusted ULOD using 60 Joules/cm³ applied to the larger ovary, while group 2 (n?=?53) underwent BLOD with fixed doses of 1200 J. Ovulation rate, anti-Mullerian hormone (AMH), antral follicle count (AFC), and pregnancy rates were assessed at 3 and 6 months of follow-up.

Results: Ovulation and pregnancy rates at 3 months periods were comparable (p?>?0.05), but was significantly higher in BLOD at 6 months period (p?p?p?>?0.05) but became higher in the ULOD at 6-month follow-up period (p?Conclusion: Dose-adjusted ULOD applied to the larger ovary has comparable ovulation and pregnancy rates to fixed dose BLOD at 3-month follow-up periods with decrease in its effectiveness after 6 months.     

超短波治疗对脊髓损伤炎症因子和丝裂原活化蛋白激酶通路的影响

目的观察超短波治疗对脊髓损伤(SCI)后炎症因子和丝裂原活化蛋白激酶(MAPK)通路的影响。方法将79只Sprague-Dawley(SD)大鼠随机分成对照组(n=35)、干预组(n=35)和假手术组(n=9)。采用Allen′s法对干预组和对照组大鼠行SCI挫压伤造模, 假手术组仅暴露脊髓组织, 不进行打击。SCI后24 h后, 干预组给予无热量超短波治疗, 每日1次, 每周5次, 每次7 min直至取材前。造模成功1 d后和各组对应的取材时间点(提前1 h), 采用SCI行为学评分(BBB)对3组未取材的大鼠进行运动功能评估。造模成功1 d、3 d、7 d后, 采用免疫荧光和免疫印迹技术观察3组大鼠损伤区域内炎症因子和MAPK通路的动态变化。结果造模成功14 d后, 干预组大鼠的BBB评分为(7.30±1.04)分, 显著优于对照组造模成功14 d后, 差异有统计学意义(P<0.05)。造模成功7 d后, 假手术组大鼠脊髓组织炎症因子NOD样受体热蛋白结构域相关蛋白(NLRP3), 白介素-6(IL-6), 白介素-6受体(IL-6R)和肿瘤坏死因子-α(TNF-α)的含量均...     

Bacterial meningitis after radiofrequency diathermy for adenoid hypertrophy

A 6‐year‐old otherwise healthy girl who underwent radiofrequency diathermy for adenoid hypertrophy presented with fever on the same day and was diagnosed as having bacterial meningitis 2 days later. Culture of cerebrospinal fluid indicated that the pathogens were penicillin‐sensitive Streptococcus pneumoniae and methicillin‐sensitive Staphylococcus aureus. The serotype of the causative pneumococcus, 11A, was not covered by the 7‐valent pneumococcal conjugate vaccine the patient had been inoculated with. Although not previously reported, radiofrequency diathermy for adenoid hypertrophy can be considered a risk factor for bacteremia and meningitis.     

热疗联合奥沙利铂与5-Fu/CF治疗晚期结直肠癌

【目的】观察局部射频透热联合化疗治疗晚期结直癌的临床疗效和不良反应。【方法】62例晚期结直肠癌患者分为化疗组和联合治疗组,化疗组以奥沙利铂加5-Fu/CF化疗,方案为奥沙利铂100mg/m2d1,5-Fu 500 mg/m2d3、d4、d6、d7、d9、d10/CF 80 mg/m2d3、d4、d6、d7、d9、d10,每3周一个疗程;联合治疗组30例行局部射频热疗配合化疗,化疗方案同化疗组,热疗在d1、d4、d7、d10进行,2个疗程后进行疗效评价。【结果】联合治疗组与化疗组的有效率分别为70%、43.75%(P<0.05),中位生存期分别为11个月与8个月(P>0.05),1年生存率分别为36.67%与28.13%(P>0.05)。两组不良反应无明显差异。【结论】射频透热可提高奥沙利铂加5-Fu/CF的对晚期结直肠癌的疗效,射频透热联合化疗安全有效。     

超短波对间充质干细胞粘附增殖及成骨能力的影响

目的 观察鼠骨髓间充质干细胞（rMSCs）受超短波作用后其粘附、增殖及成骨分化能力的变化。 方法 将rMSCs置于超短波理疗仪上，以每日1次、每次15 min的条件进行处理，1 d后检测细胞早期粘附能力，2 d后借助倒置荧光显微镜观察细胞形态，1 d、3 d、7 d检测细胞增殖能力，7 d后检测成骨相关基因骨桥蛋白(OPN)表达量。 结果 与未经超短波处理的对照组相比，接受超短波处理的超短波组早期细胞粘附数量为前者的1.8倍（P<0.05）；2 d后超短波组比对照组细胞的伪足数量多，伪足铺展范围大；超短波组细胞连续培养7 d后，与对照组相比，其增殖能力提升（P<0.05），OPN表达上调（P<0.05）。 结论 超短波能影响rMSCs的早期粘附能力和形态，能促进其增殖和向成骨方向分化。     

超短波对实验性肺间质纤维化的影响

目的　观察超短波对内毒素性肺损伤所致的肺间质纤维化的影响。方法　健康大白兔 18只 ,随机分为对照组 (C组 ) 6只 ,静脉内注入生理盐水 5ml。观察组 12只 ,大肠杆菌内毒素 0 .7mg/kg体重 ,生理盐水 5ml稀释后静脉内注入。其中 6只应用超短波治疗 1周 (A组 ) ,另 6只不做任何治疗观察 1周 (B组 )。应用透射电镜和组织化学方法观察各组肺间质纤维化形成程度及肺泡一氧化氮合成酶 (NOS)阳性染色细胞数的变化。结果　肺间质纤维化程度 ,A组与C组比较无显著性差异。B组与C组比较纤维化程度明显增多 .肺泡NOS阳性染色细胞数A组与C组比较差异无统计学意义 (P >0 .0 5 ) ,B组与C组比较 ,B组NOS阳性染色细胞数明显减少 (P <0 .0 1)。结论　超短波具有明显的保护损伤肺组织减轻肺间质纤维化的作用。其调节肺组织NOS活性的作用可能是防治肺间质纤维化的重要途径之一。