可控性丝线留置术治疗体表难治性海绵状静脉畸形的实验及临床研究

目的研究可控性丝线的致栓效果及其治疗体表难治性海绵状静脉畸形的初步疗效。方法将丝线一端留置于不同管腔大小的静脉内,另一端挂于血管壁埋于皮下,实现其可控性,用经过不同处置的丝线,分别留置于兔耳缘静脉、股静脉,观察其引起血管栓塞的效果。选择致栓效果较好的丝线组,用于临床治疗难治性体表海绵状静脉畸形的患者。结果几种经不同处置的丝线,均能不同程度地起到闭塞血管的作用,对于管腔稍大,血流较快的静脉(兔股静脉),浸泡丝裂霉素并打结的丝线组,致栓效果最好;临床初步应用证实,可控性丝线治疗体表难治性静脉畸形,安全有效。结论可控性丝线静脉内留置术,是一种安全、有效、损伤小、操作简便的治疗体表难治性海绵状静脉畸形的新方法。     

Quality Control in Laboratory Hemostasis and Thrombosis

<正>laboratory equipment,akey to success is not only high quality,complete,technician knowledge,skills,and experiment a clear purpose,select the project has specificity     

中西医结合治疗急性动脉栓塞过程中甲状腺激素测定的临床意义

目的：探讨甲状腺激素水平在急性动脉栓塞中中西医结合治疗过程中的变化规律及其临床意义。方法：利用放射免疫分析法对４０例本病患者及３０例健康对照组进行血清甲状腺激素测定，观察中西医结合治疗前后的变化，结果；４０例病人均存在在低Ｔ３、低Ｔ４和高ｒＴ３血症，且以重症病人最明显，Ｔ３水平低于０．５ｎｍｏｌ／Ｌ者病情危重，Ｔ４低于５０ｎｍｏｌ／Ｌ者预后不良；低Ｔ３、低Ｔ４和高ｒＴ３血症均随中西医结合有效治疗后     

狼疮抗凝物质45例临床分析

本文报道从1985年7月到1993年12月检出有狼疮抗凝物质患者45例,有血栓栓塞现象14例,占31.11％。我们就其病种、临床表现、实验室检查、治疗及预后进行分析。     

下肢静脉高压症顺行性静脉造影的诊断意义

本文对临床上有下肢静脉高压症的56例病人,共76条下肢,进行了顺行性静脉造影的X线研究。其中对12条下肢做了经皮腘静脉造影检查。作者认为:(1)下肢静脉高压除因下肢静脉血栓形成外,下肢深静脉瓣膜功能不全是其另一个主要原因。(2)经皮腘静脉造影是检测下肢深静脉瓣膜功能的有效、准确的方法。(3)下肢静脉造影的联合应用,在检查下肢静脉高压中具有科学性和准确性。     

Influence of Agonist, Shear Rate, and Perfusion Time on Nitric Oxide Inhibition of Platelet Deposition

Nitric oxide (NO) is a physiological species involved in inhibition of platelet adhesion and aggregation. A novel NO delivery device was utilized to quantitatively assess the effects of gaseous NO on platelet deposition to agonist-coated biomaterials in the presence of a platelet suspension. Platelet deposition was evaluated as a function of agonist (collagen, fibrinogen, or IgG), shear rate (250, 500, and 750 s^–1), and perfusion time (5, 7.5, and 15 min). The minimal aqueous surface NO concentrations and fluxes necessary for significant inhibition of platelet deposition were quantified. Platelet deposition was completely inhibited at a gaseous NO exposure of 0.1 ppm, irrespective of the platelet agonist, shear rate, and perfusion time. The corresponding aqueous surface NO concentration was 0.09 nM at 250 s^–1 as predicted by a validated model. Surface fluxes ranged between 0.3 and 0.6 femtomoles cm^–2 s^–1. The results of this study are useful for establishing generalized guidelines (i.e., NO flux requirements in the presence of agonists, shear rate, and perfusion time) for the design and development of suitable biomaterials incorporating NO to reduce platelet deposition. Further studies incorporating blood, rather than platelet suspensions, are required to provide a more complete assessment of the required NO flux necessary to inhibit platelet deposition. © 2000 Biomedical Engineering Society. PAC00: 8717-d, 8719Tt     

光化学诱导的血栓形成性脑缺血及其代谢改变

本文用光化学法激发大鼠局部脑血栓形成，以组织病理学、局部脑血流量、皮层水含量、三磷酸腺苷、二磷酸腺苷，一磷酸腺苷、能量负荷、肌酸及乳酸为指标，探讨局部脑血栓形成后５天ｒＣＢＦ明显增高的可能机理。结果表明，血栓形成后局部脑组织ＡＴＰ水平进行性减少（Ｐ＜０．０１）、ＡＤＰ／ＡＴＰ及ＡＭＰ／ＡＴＰ比值明显升高（Ｐ均＜０．０１），ＬＡ及脑水含量显著增加（Ｐ＜０．０１）。这些因素既是能量衰竭、无氧酵解的结果     

Direct blood-pressure measurements: risks,technological evolution and some current problems

The direct measurement of blood pressure has found widespread use in intensive care units, operating rooms, and in emergency departments. Infection, air embolism and thrombosis are some of the risks to patients associated with both the cannulation procedure and with the apparatus used in the blood-pressure measuring process. Although there is constant revision in an attempt to reduce these risks, they cannot be completely eliminated. The need for direct blood-pressure measurements and the physiological effects of air embolism and thrombosis are reviewed. Infection and problems related to the techniques used to insert the catheters are not discussed.