Children's risk and resilience following a natural disaster: Genetic vulnerability,posttraumatic stress,and depression

Objective

We examined children’s risk and resilience following a natural disaster, evaluating the role of stress, social support, and two genetic markers: the short allele of the serotonin transporter gene (5-HTTLPR), and the met allele of the Brain-Derived Neurotrophic Factor (BDNF).Under high levels of hurricane exposure or hurricane-related stressors, we expected children displaying the markers would report greater symptoms of posttraumatic stress disorder (PTSD) and depression than children without these markers. Social support was explored as an additional moderating variable.

Method

Eight months after Hurricane Ike, 116 children (M age=8.85 years, SD=.89; 54% girls) residing in Galveston, Texas, provided saliva samples and completed measures of hurricane exposure and stress, and symptoms of PTSD and depression; 80 also completed a social support measure.

Results

For BDNF, analyses revealed several Gene by Environment interactions; greater stress was related to more symptoms of PTSD and depression, and this effect was stronger for children with the met allele. No findings emerged for 5-HTTLPR. Stressors and social support also were associated with children’s PTSD and depressive symptoms.

Limitations

Findings should be tempered by the relatively small sample, especially for analysis that included social support.

Conclusions

The met allele (BDNF) may play a role in children’s disaster reactions. Further research should consider the complex interplay between genes, stressors, support, and psychological outcomes over time.     

高职生应激源、应付方式与心理健康的研究

目的为了探讨高职大学生群体应激源、应付方式及其与心理健康之间的关系。方法以武汉市3所高职院校共420名高职生为研究对象,采用应激泺、应付方式问卷以及心理健康自评量表（SCL-90）,对他们的应激源、应付方式和心理健康进行评定分析。结果①在所测评的5类应激源中,高职生所面临的主要应激泺有2类即：就业问题、学习问题;②高职生面临应激源时采取的主要应付方式为：解决问题、求助;③应激源、应付方式与心理健康之间有密切关系,且相关系数迭显著性水平。结论高职生应激源、应付方式与心理健康有显著相关。     

Stressors in ICU: perception of the patient, relatives and health care team

Objective: To compare the evaluation of the stressors present in the intensive care unit (ICU) from the point of view of the patient, relatives and the multiprofessional team and to identify differences and similarities with regard to the perception of stressors in order to optimize patient care. Design: Cross-sectional analytical survey. Setting: General ICU of a private hospital. Patients and participants: From April 1^st to June 30^th, 1996, 50 ICU patients during the first week of their ICU stay, 50 of their respective relatives and 50 members of the professional team directly involved in the care of these patients. Measurements and results: The Intensive Care Unit Environmental Stressor Scale (ICUESS) was administered to all patients. The relatives and health care professionals were asked to complete the ICUESS on the basis of their perception of the patient's stressors. Being in pain, having tubes in the nose or mouth, being restrained by tubes and being unable to sleep were considered by the patients, relatives and health care professionals as the main stressors. The professional team evaluated the intensity of the stressors higher than either the family or the patient. No statistical significance was detected between the intensity of the stressors as evaluated by the patient and the intensity evaluated by relatives and by the professional team. Conclusions: Being in pain, being unable to sleep and having tubes in the nose and/or mouth were pointed out as the major stressors by the three groups. There was no statistically significant correlation between the total stress scores of the patients and their relatives (r = 0.193), between the patients and the team (r = –0.002), or between the total scores of the team and the relatives (r = –0.185). The results suggest that the views of the relatives and the professional team concerning the stressors have some similar points compared to the evaluation made by the patient himself, although the intensity of the evaluation for each group corresponds to its own perception. Received: 3 March 1999 Accepted: 19 October 1999     

Evolutionary Theory and Studies of Model Organisms Predict a Cautiously Positive Perspective on the Therapeutic Use of Hormesis for Healthy Aging in Humans

Hormesis, the beneficial effects of mild stress exposures, is a well documented phenomenon in a range of organisms. The documentation mainly relies on relatively simple and controlled laboratory investigations. In order to better understand hormesis and predict the outcome of more complex and realistic conditions, a number of key issues should be investigated in much more detail. One obstacle is the development of precise treatments optimized for single individuals. Only then can we progress with the use of hormesis as a therapeutic tool for humans.     

Stressful Life Events,Culture, and Violence

This study explored the contributions of stressful life events and their interactions with social support and cultural factors in predicting serious violence among American adolescent immigrants of Chinese and Southeast Asian origins. Youth differed in their exposure to stressors and how they responded to them. Cambodian and Laotian youth reported the highest levels of stressors, except for emotional abuse. Only physical abuse was an independent predictor of serious violence for all groups, except Chinese. Perceived social support buffered the effects of some stressors, whereas increased levels of acculturation, intergenerational/intercultural conflict, and individualism placed youth at increased risk for serious violence. The results suggest that the moderating effects of culture and social support need to be considered when examining the association between life stressors and serious violence for Chinese and Southeast Asian youth.     

Relations among Stressors,Strains, and Substance Use among Resident Physicians

This study examined the relationship between work-related stress and substance use among resident physicians in the United States. Unlike previous studies of physician stress, this study distinguished between “stressors” (stressful job conditions) and “strains” (reactions to the work environment) and correlated each of these with substance use. Results indicated that relations among stressors, strains, and substance use were not strong. Strains, however, were more strongly related to substance use than stressors. Additionally, benzodiazepines were more strongly related to strains than other substances, suggesting that they may be used for self-treatment. Other implications of these findings and future research needs are discussed.