全文获取类型
收费全文 | 695篇 |
免费 | 13篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 2篇 |
基础医学 | 54篇 |
口腔科学 | 1篇 |
临床医学 | 20篇 |
内科学 | 8篇 |
神经病学 | 69篇 |
特种医学 | 12篇 |
外科学 | 22篇 |
综合类 | 78篇 |
预防医学 | 12篇 |
眼科学 | 3篇 |
药学 | 404篇 |
中国医学 | 26篇 |
肿瘤学 | 1篇 |
出版年
2017年 | 4篇 |
2016年 | 3篇 |
2015年 | 7篇 |
2014年 | 15篇 |
2013年 | 13篇 |
2012年 | 15篇 |
2011年 | 23篇 |
2010年 | 17篇 |
2009年 | 22篇 |
2008年 | 26篇 |
2007年 | 26篇 |
2006年 | 21篇 |
2005年 | 21篇 |
2004年 | 22篇 |
2003年 | 20篇 |
2002年 | 14篇 |
2001年 | 13篇 |
2000年 | 9篇 |
1999年 | 14篇 |
1998年 | 13篇 |
1997年 | 21篇 |
1996年 | 15篇 |
1995年 | 25篇 |
1994年 | 13篇 |
1993年 | 14篇 |
1992年 | 21篇 |
1991年 | 16篇 |
1990年 | 14篇 |
1989年 | 7篇 |
1988年 | 18篇 |
1987年 | 13篇 |
1986年 | 12篇 |
1985年 | 14篇 |
1984年 | 17篇 |
1983年 | 7篇 |
1982年 | 18篇 |
1981年 | 18篇 |
1980年 | 10篇 |
1979年 | 11篇 |
1978年 | 10篇 |
1977年 | 7篇 |
1976年 | 16篇 |
1975年 | 16篇 |
1974年 | 14篇 |
1973年 | 15篇 |
1972年 | 9篇 |
1971年 | 3篇 |
1970年 | 6篇 |
1969年 | 6篇 |
1968年 | 3篇 |
排序方式: 共有714条查询结果,搜索用时 312 毫秒
1.
Jean-Marie Danion Marie-Agathe Zimmermann Dominique Willard-Schroeder Danielle Grangé Marie Welsch Jean-Louis Imbs Léonard Singer 《Psychopharmacology》1990,102(3):422-424
The effects of scopolamine, an anticholinergic drug, of trimipramine, a tricyclic antidepressant with both anticholinergic and sedative properties, of diazepam and a placebo, on explicit memory and repetition priming were assessed using a free-recall task and a word-stem completion task. Forty-eight healthy volunteers took part in this double-blind study. Diazepam provoked a dissociation between free recall, which was profoundly impaired, and word completion, which was spared. No significant changes in memory performances were observed in the scopolamine group; however, a significant correlation between explicit and implicit memory performances was observed in this group. At the low dose used, the effects of trimipramine on memory were mild. The results suggest that the cholinergic system is involved in the priming effect. 相似文献
2.
应用Y型迷宫研究了急性与慢性东莨菪碱和吗啡对小鼠记忆能力的影响。单剂量东莨菪碱(1mg/kgip)和吗啡(10mg/kgip)均能显著损害小鼠的短时记忆(workingmemory)。重复给药后东莨菪碱的这种作用很快消失。但吗啡每天一次,连续3次给药这种作用加强,连续5次给药这种作用反而减弱。东莨菪碱不能损害小鼠长时记忆(referencememory),而吗啡对长时记忆有损害作用。结果还提示小鼠短时记忆不受自发活动能力的影响。 相似文献
3.
P. Riekkinen Jr. P. Jkl J. Sirvi E. Koivisto R. Miettinen P. Riekkinen 《Brain research bulletin》1991,26(4):633-637
The effectiveness of THA (an anticholinesterae) on scopolamine (0.4 mg/kg) and nucleus basalis (NB) lesion-induced change in neocortical spectral electroencephalography (EEG) were investigated. Scopolamine increased the amplitudes of all the spectral components in waking-immobility. In the movement-related EEG spectral values, only the alpha power was increased. THA 7.5 mg/kg, but not THA 3 mg/kg, could reverse scopolamine-induced amplitude change. NB lesioning increased delta and theta amplitudes, but decreased beta amplitude. Delta amplitude was increased during movement recordings in NB-lesioned rats. THA 7.5 mg/kg and pilocarpine 10 mg/kg, but not THA 3 mg/kg, could partially reverse the increase of delta and theta amplitudes induced by NB lesions. However, the beta power decrease could not be restored with cholinomimetics. This study demonstrates that quantitative EEG activity analysis may reflect the THA-induced restoration of the function of the cholinergic nucleus basalis. 相似文献
4.
侧脑室注射东莨菪碱和酚妥拉明对幼兔分辨学习的影响 总被引:3,自引:1,他引:2
目的 探讨东莨菪碱和酚妥拉明对幼兔分辨学习的影响。方法 将30只比利时纯种幼兔从生后13日龄随机分为三组:东莨菪碱组、酚妥拉明组和生理盐水对照组,观察不同日龄各组幼兔的分辨学习能力。结果 幼兔分辨学习的正确反应一般始于生后15日龄。侧脑室注射东莨菪碱对16日龄以前幼兔分辨学习无明显影响,对17日龄以后幼兔分辨学习产生明显抑制作用。侧脑室注射酚妥拉明对13—23日龄幼兔分辨学习均有明显抑制作用。结论 幼兔生后发育过程中学习能力的发展具明显的阶段性,其原因可能与神经递质系统的发育成熟有关。 相似文献
5.
Masafumi Ogawa Yasuhiro Magata Yasuomi Ouchi Hidenao Fukuyama Hiroshi Yamauchi Jun Kimura Yoshiharu Yonekura Junji Konishi 《Brain research》1994,650(2):249-252
The effect of the cholinergic blocker, scopolamine on the cerebral blood flow (CBF) response to vibrotactile stimulation of a fore paw was studied using high-resolution positron emission tomography and H215O in 5 pentobarbital-anesthetized cats. Before scopolamine injection, the CBF response to the stimulation was found in the contralateral somatosensory cortex (mean ratio (contralateral/ipsilateral) control: stimulated1.02 ± 0.02: 1.17 ± 0.05; P < 0.01). After intravenous injection of scopolamine (0.35 mg/kg), the CBF response was abolished. However, the cerebral metabolic rate of glucose (CMRGlu) response to the same stimulation was unchanged after scopolamine injection in the same cats. We concluded that scopolamine abolishes the CBF response but not neuronal response to stimulation. We suggest that cholinergic mechanisms may play an important role for mediating CBF coupling to neuronal activity during physiological stimulation. 相似文献
6.
7.
目的 观察东莨菪碱对大鼠下丘脑室核精氨酸升压素的影响。方法 以不同浓度Scop推挽灌流大鼠下丘脑室旁核 结果 扣留出液中精氨酸升压素含量随推挽时间延长而增多。结论Scop可促进PVN释放内源性AVP,这对了解Scop抗休克的机理有重大的意义。 相似文献
8.
The effects of clonidine and yohimbine on human information processing were tested in six normal volunteers ages 18–30 years. Subjects were tested in a pre-post design with sessions conducted at weekly intervals. Three drug conditions were: Placebo (lactose), 0.2 mg clonidine, and 30 mg yohimbine. Two choice reaction time (RT) tasks were used. One was a stimulus evaluation-response selection task (SERS) that has been shown to be sensitive tod-amphetamine, methylphenidate and scopolamine. The other task was to assess stimulus pre-processing and used spatial frequency as a discriminative stimulus. The principle finding was that clonidine slowed RT; this effect was significant for both tasks. In contrast, yohimbine tended to speed RT, but the effects were significant only for the spatial frequency task on some analyses while not for others. RTs to high spatial frequency stimuli were speeded more than for low spatial frequency. The effects of these two NE drugs were compared with findings withd-amphetamine and scopolamine and interpreted within the framework of a serial information processing model proposed by Callaway (1983). Specifically, it is suggested that yohimbine and clonidine affect an early pre-processing stage. 相似文献
9.
Exploratory activity: genetic analysis of its modification by scopolamine and amphetamine 总被引:3,自引:0,他引:3
Short-term exploratory activity was found to be significantly higher in C57BL/6By than in BALB/cBy inbred mice. Scopolamine reversed the activity levels in these strains. Basal exploratory activity levels and the effects of scopolamine on this behavioral measure assessed in these two strains, their reciprocal F1 hybrids, their recombinant inbred strains and three C57BL/6 congenic lines permitted characterization of a gene exerting a major effect on short-term exploratory activity [Exa, linked to H(w26), chromosome 4 (LG VIII)] and of a gene modulating the effects of scopolamine in this behavior, [Sco, linked to H-2, chromosome 17 (LG IX)]. Amphetamine exerted opposite effects in relation to those exerted by scopolamine on activity and its action was found to be determined by a polygenic system. 相似文献
10.
Two experiments investigated the effect of electroconvulsive shock on the performance of a one-way active avoidance response. In the first experiment it was found that if the response was learned under scopolamine, ECS given prior to relearning failed to produce a deficit. The second experiment demonstrated that ECS facilitated relearning of a response trained to a low criterion level while it disrupted performance of a response trained to a strict criterion. These results support other indications that Deutsch's memory model has predictive value for proactive effects of ECS on relearning (retrieval). 相似文献