山莨菪碱外用佐治新生儿硬肿症临床观察

目的:观察山莨菪碱(654鄄2)外用对新生儿硬肿症的效果。方法:将住院新生儿硬肿症患儿分为治疗组和对照组,两组均采用常规治疗,治疗组加用654鄄2辅佐治疗。结果:治疗组与对照组在治愈率上无显著差异(P>0.05),但治疗组在体温回升时间、硬肿消退时间和住院时间明显短于对照组(P<0.05)。结论:654鄄2可提高新生儿硬肿症的治疗效果。     

Sclérœdème de Buschke traité efficacement par photophérèse extracorporelle

Background

Scleredema adultorum (Buschke's scleredema) is a cutaneous mucinosis of unknown origin, clinically characterized by a diffuse induration of the skin usually involving the neck, shoulders and back, which limits patients’ mobility.

Scleroedema adultorum bei sekundärem Hyperparathyreoidismus

Scleredema adultorum, or Buschke's scleredema, belongs to the group of mucinoses. It is characterised by thickened and indurated skin. Histopathology shows thickened dermis with an infiltration of mucin between swollen collagen bundles. There are reports about many associations with scleredema adultorum, e.g., with diabetes mellitus and multiple myeloma. One case is known with associated primary hyperparathyroidism. For the first time we report a case of scleredema adultorum and secondary hyperparathyroidism, in a 46-year-old patient. Both forms of hyperparathyroidism have increased levels of parathormone. Therefore, these increased levels could have an influence on collagen metabolism.     

新生儿硬肿症死亡原因分析与护理体会

目的探讨致新生儿硬肿症死亡的原因及护理措施,以提高治愈率及护理疗效。方法通过回顾性总结2009年8月～201年8月我科收治的新生儿硬肿症203例的临床资料。结果治愈148例,死亡55例,病死率占37.2%。死亡组直接死亡疾病:DIC并肺出血、消化道出血32例,呼吸衰竭5例,肾功能衰竭5例,严重心力衰竭3例,上呼吸机合并严重肺部感染3例,败血症并中毒性脑病2例,低钠脑病1例,放弃治疗4例。结论新生儿硬肿症病死率与胎龄、体重、硬肿程度、发病季节、并发症等有关系,窒息、感染、早产、低体重、低温、护理方式等是影响新生儿硬肿症预后的重要因素,应加强围产期保健、提倡住院分娩、注意新生儿体温护理、预防感染、加强病情观察等,以减少新生儿硬肿症的发生及死亡。     

云南白药、654-2外用辅治新生儿硬肿症

目的:评价云南白药与654-2混合外用对新生儿硬肿症的辅助治疗作用。方法:将住院病人分为治疗组和对照组,治疗组除常规治疗外外用云南白药和654-2混合制剂,对照组常规治疗。比较两组的治愈率和临床表现。结果:治疗组与对照组在治愈率上无显著差异(P>0.05),但在体温回升时间、硬肿消退时间和住院时间等临床表现方面具有明显优势(P<0.05)。结论:云南白药与654-2外用辅助治疗新生儿硬肿症可明显改善临床体征,提高患儿的生存状况。     

Two cases of diaper area granuloma of the adult.

Two cases of diaper area granuloma are reported. Patient 1, a 34-year-old man, had multiple reddish-purple nodules over the diaper area of the right part of the genitocrural region. Candida albicans was not detected from the lesion. Histological examination of the nodule showed acanthosis and dense infiltrates. The granulomas became smaller and flatter after the control of urination. Patient 2, a 28-year-old man, had two large decubitus lesions and multiple nodules over the diaper area of the gluteal region. The decubitus became smaller and the granulomas disappeared after the lesion was kept clean. Because these granulomas resemble granuloma gluteale infantum, but occurred in adults rather than in the aged or infants, we propose to call this condition "granuloma gluteale adultorum." We suggest that these granulomas may represent an inflammatory reaction to the irritation of urine or feces. It is, therefore, of great importance to treat and prevent this condition by controlling the flow of urine and keeping the region clean.     

Scleredema: report of a case

We describe a patient with scleredema. Thickened skin was observed in the posterior region of her neck, shoulders, and back. A skin biopsy revealed thickened dermis consisting of numerous thickened collagen bundles. Laboratory data revealed that she was suffering from diabetes mellitus (DM). The skin lesions ameliorated within a period of one month when her DM condition was controlled by oral hypoglycemics. Scleredema is a rare connective tissue disorder; its cutaneous manifestation should be distinguished from scleroderma. Received: February 8, 1999 / Accepted: August 20, 1999     

多巴胺联合维生素E佐治新生儿硬肿症疗效观察

目的：探讨多巴胺联合维生素E佐治新生儿硬肿症的疗效。方法：将125例新生儿硬肿症患儿采用抽签法随机分为观察组65例,对照组60例。两组基础治疗相同,观察组给予多巴胺2～5μg／（k·分钟）,静脉输液泵输入2小时／次,2;L／日,疗程3～5天。并同时给予维生素E液外涂硬肿部位,轻柔按摩,每次5-10分钟,3～4次／日,疗程3—5天。观察各项临床症状及体征恢复正常时间、总有效率及不良反应等。结果：观察组总有效率与对照组比较,差异有统计学意义（P〈0．01）。结论：多巴胺联合维生素E佐治新生儿硬肿症有效、安全,值得推广。     

血活素佐治新生儿硬肿症临床疗效观察

目的:探讨新生儿硬肿症的治疗方法。方法:将66例新生儿硬肿症患儿随机分为常规组和血活素组各33例。血活素组在常规治疗基础上佐以血活素治疗。结果:血活素组总有效率87.88％,优于常规组57.58％,两组比较u=2.890,P<0.01;皮肤硬肿消失时间血活素组(4.1±1.32)d,常规组(5.2±1.51)d,两组比较t=3.081,P<0.01。结论:在常规治疗基础上佐以血活素治疗,是目前治疗新生儿硬肿症的有效方法之一。     

复方维E紫草油外用治疗新生儿硬肿症

目的:观察复方维Ｅ紫草油外用对新生儿硬肿症的治疗效果。方法:在常规治疗方法的同时采用每１０ｍｌ复方紫草油中加入２００ｍｇ维生素Ｅ外涂硬肿部位,配合局部按摩５~１０ｍｉｎ,３~５次/ｄ,以４日内硬肿消失或大部分消失,剩余部分变软判为有效。结果:治疗组２日内有效率４６．８８%,４日内有效率９０．６３%,死亡率３．１３%。对照组２日内有效率 １３．３３%,４日内有效率４３．３３%,死亡率１０%,两组比较有显著差异性(Ｐ＜０．０１)。结论:复方维Ｅ紫草油外用为治疗新生儿硬肿症的一种有效方法之一。