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盐酸仑氨西林片与阿莫西林胶囊随机双盲双模拟对照治疗急性细菌性感染临床评价 总被引:1,自引:0,他引:1
目的评价盐酸仑氨西林片治疗急性细菌性感染的疗效和安全性。方法以阿莫西林胶囊为对照药,观察49例受试者,其中盐酸仑氨西林片治疗25例,阿莫西林胶囊治疗24例。2种药物均以500mg,每日3次给药,疗程7~14d。结果盐酸仑氨西林片与阿莫西林胶囊两组痊愈率分别为68.0%和70.8%,有效率分别为90.2%和100%。细菌清除率分别为93.3%和100%。不良反应发生率分别为12.0%和4.2%。经统计学检验两组结果差异无显著性。分离出的29株致病菌对盐酸仑氨西林的敏感率为89.7%,与阿莫西林、头孢呋辛、环丙沙星和头孢拉定比较敏感率差异无显著性。结论盐酸仑氨西林片治疗急性细菌性感染是安全和有效的。 相似文献
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HPLC法测定盐酸仑氨西林的含量及有关物质 总被引:1,自引:0,他引:1
目的 采用高效液相色谱法测定盐酸仑氨西林含量及有关物质。方法 ODS- C1 8柱 (2 5 0 mm×4 .6 mm,5 μm) ,流动相为 0 .0 78mol/ L 磷酸二氢钾溶液 -乙腈 (75∶ 2 5 ) ,流速 1.0 ml/ min,柱温 4 0℃ ,检测波长2 30 nm。结果 盐酸仑氨西林在 0 .10~ 0 .4 0 mg/ ml的浓度范围内呈良好的线性关系 ,回归方程为 Y=1392 0 5 X- 15 5 1.5 (r=0 .9997) ,最低检测浓度为 0 .6 2 5 μg/ ml,平均回收率为 99.74 % (n=9) ,RSD=0 .2 4 %。结论 本方法简便、快速 ,结果准确、可靠、重现性好。 相似文献
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T. Yoshii Y. Hamamoto S. Muraoka S. Furudoi T. Komori 《Journal of infection and chemotherapy》2002,8(1):87-93
The aim of this study was to examine the effect of antibiotic prophylaxis for mandibular third molar surgery from the viewpoint
of the duration of administration. A comparative study was conducted on postoperative infection, dry socket, and the healing
process in 178 healthy patients receiving 1-day or 3-day prophylaxis with lenampicillin (LAPC; 1.5 g/day). Postoperative infection
developed in only 1 (1.1%) of the 91 patients in the 3-day group, while there was no patient with infection in the 87 patients
in the 1-day group. Dry socket developed in 8.0% of the 87 patients in the 1-day group and in 7.7% of the 91 patients in the
3-day group. However, the incidence of these complications, in relation to the degree of impaction of the molars, did not
significantly differ between the 1-day and 3-day groups. Scores indicating clinical symptoms for the 7 days after surgery
also reflected no significant difference between the groups, irrespective of the degree of impaction. These results suggest
that 1-day therapy with LAPC in our regimen may at least be recommended as a prophylaxis for mandibular third molar surgery
in medically healthy patients.
Received: July 31, 2001 / Accepted: November 9, 2001 相似文献
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