复方薰衣草颗粒镇静催眠及改善认知障碍作用研究

目的 观察复方薰衣草颗粒（CLG）镇静催眠及对轻度认知功能障碍（MCI）模型小鼠的治疗作用。方法 （1）CLG镇静催眠和抗抑郁、抗疲劳作用研究：以旷场训练结果为主要条件、体质量为次要条件，随机将79只ICR小鼠分为对照组、地西泮（3 mg·kg^-1，化药阳性药）组、复方枣仁胶囊（12.3 mg·kg^-1，中药阳性药）组和CLG低、中、高剂量（2.36、4.72、9.44 g·kg^-1）组。采用戊巴比妥钠阈下剂量催眠、旷场和转棒实验，观察CLG对小鼠的一般状态、睡眠潜伏期、30 min内入睡比例和总睡眠时间以及行为学的影响。（2）CLG改善MCI作用研究：将60只昆明小鼠以Y迷宫实验训练结果为主要条件、体质量为次要条件随机分为对照组、模型组、多奈哌齐（3 mg·kg^-1，阳性药）组和CLG低、中、高剂量（2.36、4.72、9.44 g·kg^-1）组，每天1次，连续ig给药14 d，给药第9天起，给药1 h后，除对照组外，ip 3 mg·kg^-1东莨菪碱制备MCI模型。于末次给药20 min后进行Y迷宫实验；第15天进行跳台实验；解剖取脑，称取脑质量并计算脑系数；HE染色后观察脑组织病理改变；取海马，ELISA法测定乙酰胆碱（Ach）、乙酰胆碱酯酶（AchE）、超氧化物歧化酶（SOD）、丙二醛（MDA）、谷胱甘肽（GSH）水平。结果 （1）与对照组比较，CLG各剂量对体质量无明显影响；地西泮组和CLG各剂量组入睡率有增高趋势，但无显著性差异；地西泮组和CLG高剂量组入睡潜伏期明显缩短（P<0.05） ；各给药组睡眠时间均显著延长（P<0.01）。（2）与模型组比较，多奈哌齐组和CLG各剂量组跳台次数均显著减少（P<0.05）；CLG各剂量组Ach有升高趋势，多奈哌齐组和CLG中、高剂量组AchE有降低趋势；CLG各剂量组SOD显著增加，MDA显著降低（P<0.05）；CLG中、高剂量组小鼠皮层和海马病理改变明显减轻。结论 CLG具有镇静催眠作用，其改善MCI的作用可能与调节胆碱能系统和抗氧化应激有关。     

Sustainable fragrance cum antimicrobial finishing on cotton: Indigenous essential oil

Fragrance finishing of textile has been enormously increased and used in domestic and industrial application. Fragrance can be synthesis chemically but available in natural and inorganic. The investigation of this research is to study the combined effect of fragrance and antimicrobial finishing on cotton fabric by lavender essential oil with the use of β-Cyclodextrin, Chitosan citrate and β-Cyclodextrin/Grafted Chitosan through pad-dry method. Fourier Transform Infrared spectroscopy (FTIR) was used to study the formation of ester bonds between β-cyclodextrin/grafted chitosan and cotton celluloses. For all the finished fabric samples fragrance release rate performance and antimicrobial properties were measure by standard test methods. The results revealed that β-CD was highly soluble in 0.6 gpl NaOH solution and 80 gpl β-CD and 6% essential lavender oil solutions were found to be a most suitable combination for fragrance and antimicrobial finishing. FTIR studies reveal about the formation of a carboxylic ester between cotton and β-Cyclodextrin/Grafted Chitosan at 1730 cm^?1 ester peak.     

The effects of aromatherapy with lavender essential oil on fatigue levels in haemodialysis patients: A randomized clinical trial

ObjectiveThis study was intended to examine the efficacy of lavender essential oil for the alleviation of fatigue in haemodialysis patients.Methods and materialsThis randomized clinical trial was conducted on 59 haemodialysis patients in two groups. The routine care group received the routine care, but the experimental group inhaled lavender essence 5% for 10 min, three times a week for 4 consecutive weeks. The Fatigue Severity Scale was used to assess fatigue before the intervention and after the last intervention in the second and fourth weeks.ResultsNo statistically significant differences were observed between the two groups in terms of the fatigue scores before, and after the last intervention in the second and fourth weeks.ConclusionOur result does not support other studies suggesting that lavender essential oil is effective on fatigue in haemodialysis patients. This conflicting result can mostly be ascribed to a variety of factors such as duration of aromatherapy and differences in concentrations of lavender essential oil.     

Effects of glycerin oil and lavender oil massages on hemodialysis patients’ restless legs syndrome

ObjectivesTo determine the effects of glycerin oil and lavender oil massages on hemodialysis patients’ restless legs syndrome (RLS).MethodsNinety hemodialysis patients with RLS were randomly allocated into two intervention groups and one control group, each consisting of 35 participants. The control group received routine care, and the intervention groups received effleurage massage with lavender and glycerin oil in addition to routine care for one month. RLS intensity was measured among the three groups using the Restless Legs Syndrome Rating Scale.ResultsAt the beginning of the study, the results showed no significant difference among the three groups’ scores. At the end of the study, the mean RLS scores were significantly lower in the intervention groups compared to the control group (F = 63.4, p ≤ 0.001). This difference was not significant between the two intervention groups; nonetheless, the differences between the control and lavender oil groups, as well as the control and glycerin oil groups, were significant (p < 0.05).ConclusionThe findings showed the effectiveness of the oils through the effleurage massage for reducing RLS in a sample of hemodialysis patients.     

The Effect of Lavender Aroma on Anxiety of Patients Having Bone Marrow Biopsy

Introduction: Bone marrow biopsy is a common procedure for the diagnosis and treatment of hematologic diseases and tumors, which are associated with anxiety. The purpose of this study was to examine the effect of lavender aroma on anxiety of patients having bone marrow biopsy. Materials and Methods: This study was performed on 80 patients referred to Vali-e-Asr Hospital for bone marrow biopsy. Samples were selected by convenience method and were assigned into intervention and control groups using randomized blocks of 4. Random sequence was generated by RAS software. Several drops of distilled water on a cotton ball was used in the control group and same amount of lavender essential oil on a cotton ball was used in the intervention group. Then, participants in both groups were asked to smell the cotton ball for 15 minutes and then, their anxiety level was measured immediately. The results were analyzed by SPSS software version 25 using covariance analysis and rank regression. Results: The results showed that, the mean scores of anxiety in the control and intervention groups were 6.3 ± 1.92 and 3.75 ± 1.05, respectively. There was a significant difference (p <0.05) between the two groups in terms of anxiety score.The results showed that there was a significant difference in anxiety score between two groups in terms of variables such as age, gender, physician experience, biopsy history and biopsy site (P <0.05). The results also showed no significant difference between the (p >0.05). Conclusion: The results of this study showed that bone marrow biopsy is associated with anxiety, and smelling of lavender aroma is effective in reducing anxiety in patients undergoing this procedure. This fragrance can be used by treatment team in hematology and oncology clinics to reduce anxiety caused by bone marrow biopsy.     

Effect of Lavender cream with or without footbath on sleep quality and fatigue in pregnancy and postpartum: a randomized controlled trial

Sleep disturbance and fatigue are frequent complaints during pregnancy and postpartum. We assessed the effectiveness of Lavender cream and footbath on sleep quality and fatigue in pregnancy and postpartum. In this trial, 141 women with sleep disturbance at 25–28 weeks gestation were recruited from public health centers in Tabriz, Iran, from May 2013 until January 2014 and randomized into one of three groups receiving: Lavender and footbath, Lavender alone, or placebo cream. Sleep quality was assessed using the Pittsburgh sleep quality index at the 4th and 8th weeks after intervention and the 6th week postpartum. Fatigue was assessed with the multidimensional assessment of fatigue scale at the 6th week after intervention and the 6th week postpartum. Repeated measures ANOVA and ANCOVA were used. Compared with the placebo group, the global sleep quality score post-intervention in pregnancy and the postpartum were significantly lower in the Lavender and footbath and the Lavender cream only groups. Fatigue in both intervention groups was significantly improved only at the 6th week postpartum. No statistically significant differences were observed between the two intervention groups. Lavender cream with or without footbath may improve sleep quality in pregnancy and postpartum.     

Aromatherapy Hand Massage for Test Anxiety and Self-Efficacy in Nursing Students: A Pilot Study

The purpose of this study was to determine if aromatherapy hand massage (HM) could improve test anxiety and self-efficacy in nursing students. Participants were randomized to receive aromatherapy hand massage (AHM), unscented HM, or no intervention (C) 60 minutes before an examination. No significant differences were found, but analysis of the percentage change from the means demonstrated the largest decrease in test anxiety in the AHM group (AHM = ?12.4%, HM = ?8.63%, C = ?1.76%). Self-efficacy trends followed a similar pattern (AHM = 5.93%, HM = ?3.03%, C = 0.52%). The trends in the percentage change from the means indicate that a larger sample may show improvements in test anxiety and self-efficacy with the use of AHM, which could improve nursing students’ academic performance and decrease attrition rates.     

A systematic review of the effect of lavender on cancer complications

ObjectiveDespite advances in the diagnosis and treatment of cancer, patients still suffer from the various physical and psychological complications of cancer. The aim of this research was to integrate and synthesize relevant scientific evidence about the effect of lavender on cancer complications.MethodsA systematic review of the international literature was undertaken. The search process encompassed four databases of PubMed [including MEDLINE], Web of Science, Scopus, and Cochrane library without time and language limits. All types of interventional studies examining the effects of lavender on cancer complications were included in data analysis and research synthesis. Relevant data were obtained from eligible studies after quality appraisal using appropriate methodological tools. Given that meta-analysis could not performed, the review findings were synthesized narratively.ResultsThirteen studies were included in this review with a total of 838 patients. Nine studies used a randomized controlled trial design and the majority of them were conducted on patients with multiple types of cancer. Lavender was often used as inhalation aromatherapy. In the majority of the included studies, lavender was significantly effective in the reduction of anxiety and pain, and improved sleep quality and vital signs.ConclusionsThis review provides scientific evidence regarding the effectiveness of lavender in mitigating cancer complications. Healthcare providers are suggested to use lavender in patient care along with other healthcare interventions to relieve cancer complications.