Mortality outcomes based on ED qSOFA score and HIV status in a developing low income country

Objective

To evaluate the utility of the quick Sepsis-related Organ Failure Assessment (qSOFA) score to predict risks for emergency department (ED) and hospital mortality among patients in a sub-Saharan Africa (SSA) setting.

顾锡镇教授从脾肾论治肌萎缩侧索硬化症经验

肌萎缩侧索硬化症是一种病因不清的致死性神经系统罕见病,临床表现为进行性加重的肌无力、肌肉萎缩及延髓麻痹,最终累及呼吸肌致呼吸衰竭而死亡。顾锡镇教授从脾肾论治,运用健脾补肾法治疗该病在延缓疾病进展与改善生活质量方面取得了一定疗效。文章总结了顾教授辨治肌萎缩侧索硬化症的临床经验,并例举1个典型医案加以佐证。     

黄芪建中汤对脾胃虚寒证胃溃疡大鼠的影响

目的探讨黄芪建中汤对脾胃虚寒证胃溃疡大鼠的影响。方法将SD大鼠随机分为正常组、模型组、埃索美拉唑组(4.17 mg/kg)及黄芪建中汤低、高剂量组(9.27、18.54 g/kg)。采用番泻叶(10 m L/kg)联合游泳力竭法建立脾胃虚寒证候模型,无水乙醇(10 m L/kg)联合阿司匹林肠溶片(200 mg/kg)建立胃溃疡模型。观察并记录大鼠的整体状态、体质量、进食量、饮水量和肛温,肉眼及HE染色观察胃黏膜组织形态学损伤,测量胃液总酸度和胃蛋白酶活性,ELISA法检测大鼠血清IL-4、IL-10、NO和TNF-α水平,qRT-PCR和免疫组化法分别检测TLR-2、MyD88 mRNA及蛋白表达。结果与模型组比较,黄芪建中汤组大鼠体质量、进食量、饮水量和肛温均上升(P<0.05,P<0.01),溃疡指数下降(P<0.01),胃酸总酸度和胃蛋白酶活性均降低(P<0.01),血清TNF-α水平下降(P<0.05、P<0.01),IL-4、IL-10和NO水平上升(P<0.05、P<0.01),胃组织中TLR-2、MyD88 mRNA及蛋白表达下调(P<0.01)。结论黄芪建中汤对脾胃虚寒型胃溃疡大鼠有显著的疗效,其作用机制可能通过调节TLR-2/MyD88信号通路,影响炎性因子表达,下调黏膜攻击因子水平,从而加速胃黏膜溃疡修复。     

谷康泰灵治疗原发性骨质疏松症的疗效观察

为观察谷康泰灵注射液治疗女性原发性骨质疏松症的疗效 ,将 75例患者按身高、体重、年龄、绝经后时间及治疗前骨密度值等条件相近分为 3组 ,对照组服用钙制剂 ,谷康泰灵肌肉注射组服用钙制剂同时给谷康泰灵注射液 4ml肌肉注射 ,谷康泰灵静脉滴注组服用钙制剂同时给谷康泰灵注射液 4ml加入生理盐水中静脉滴注 ,治疗期半年。测量治疗前后患者的骨密度及血清Ca、P、BGP、ALP及TRAP。结果谷康泰灵注射液肌肉注射组和静脉滴注组患者骨密度及骨代谢指标较治疗前和对照组变化显著 ,骨密度和血清ALP、BGP明显升高 ,血清TRAP活性显著下降 ,并有效的缓解了疼痛症状 ,且谷康泰灵静脉滴注组效果好于肌肉注射组。表明谷康泰灵注射液可促进成骨、抑制破骨细胞的骨吸收 ,增加骨量 ,改善骨质疏松。     

Vascular changes in flexor tendons after injury and repair: an experimental study.

Two groups of experiments were carried out on the profundus tendons of New Zealand rabbits: 1. Simple closed tenotomies at various levels along the digit. 2. Open tendon division followed by repair with a Bunnell criss-cross suture. At intervals after the operation injection studies were performed to outline the vascular pattern within the tendons. The results indicate that the circulation through the intratendinous vessels is precarious and it may be impaired both by tenotomy and by the presence of sutures. It is suggested that this may be an important factor in the pathogenesis of adhesions. The clinical implications are discussed.     

胃溃疡癌变的X线表现特征分析

目的:分析胃溃疡癌变的X线表现特征。方法:回顾性分析32例胃溃疡癌变患者的临床资料,分析其X线表现特征。结果:32例胃溃疡癌变患者的X线表现:溃疡口部幽门侧先发生改变23例(78%),结节状充盈缺损者25例(72%),溃疡轮廓改变者18例(56%),侧壁直角征者13例(41%),粘膜改变者25例(78%),有迁移征象者9例(28%),局部胃壁蠕动减弱或消失者21例(66%)。结论:X线钡餐检查是胃溃疡恶变的诊断及鉴别诊断中较为常用的一种方法。但不能只求单一征象,应全面系统地进行分析,提高胃溃疡癌变的诊断率。     

西药联合中药消溃平汤剂治疗消化性溃疡的疗效观察与护理

目的 探讨中药消溃平汤剂治疗胃及十二指肠溃疡疗效及护理措施.方法 随机将85例消化性溃疡患者分为治疗组53例和对照组32例.两组均服用奥美拉唑、阿莫西林、克拉霉素,治疗组另加服中药消溃平汤剂.疗程4周.疗程结束后比较两组治疗有效率、复发率及幽门螺杆菌(Hp)根除率.结果 两组治愈有效率、复发率、Hp根除效果均有统计学意义(P＜0.05).结论 中药消溃平汤剂联合西药治疗胃及十二指肠溃疡比单用西药在加速溃疡面愈合,增强对Hp的根除作用,减少复发有显著的协同作用.护理上指导患者正确服食汤药有助于药效发挥.     

Investigation of bladder dose and volume factors influencing late urinary toxicity after external beam radiotherapy for prostate cancer

BACKGROUND: We sought to identify the bladder dose-volume factors associated with an increased risk of late urinary toxicity among prostate cancer patients treated with radiotherapy. METHODS AND MATERIALS: This retrospective analysis included data from 128 prostate cancer patients treated on protocol with 2 Gy/fraction to 46 Gy followed by a boost to 78 Gy. The endpoint for this analysis was Grade 1 or greater late genitourinary (GU) toxicity occurring within two years of treatment. The Lyman-Kutcher-Burman, mean dose, threshold dose, and hottest volume models were fitted to the toxicity data using the maximum likelihood method. RESULTS: Model fits based on dose-volume histograms tended to fit the toxicity data better than models based on dose-wall histograms. The hottest volume (hotspot) model was found to be the best-fitting model investigated. The best fit was for the hottest 2.9% of bladder (95% CI, 1.1-6.8%). This model has an area under the receiver operating characteristic curve of 0.74. The hotspot model separated the patients into clinically meaningful subgroups with approximately 25% of the patients who received <78 Gy to the hottest 2.9% of bladder had GU toxicity at eight years compared with approximately 50% when the dose was > or =78 Gy (p = 0.002). CONCLUSION: This provides the first evidence supporting that bladder "hotspots" are related to GU toxicity within two years after external beam radiotherapy for prostate cancer. Confirming data are needed from other investigators. Particular attention should be given to hotspots higher than 78 Gy in bladder in radiation treatment planning.     

A clinical, endoscopic and pathological study of ulcer-carcinoma: report of 210 cases.

A multicentre retrospective study of ulcer-carcinoma was carried out in 16 hospitals in China, with the aim of examining the correlation between pre-cancerous lesions and malignant change associated with benign gastric ulcer. Malignant change occurred at 2% over a variable period of 6 months to 15 years. About two-thirds of the ulcer cancers were found to be tubular adenocarcinoma.