全文获取类型
收费全文 | 10361篇 |
免费 | 623篇 |
国内免费 | 1199篇 |
专业分类
耳鼻咽喉 | 966篇 |
儿科学 | 116篇 |
妇产科学 | 112篇 |
基础医学 | 304篇 |
口腔科学 | 73篇 |
临床医学 | 1148篇 |
内科学 | 3839篇 |
皮肤病学 | 26篇 |
神经病学 | 271篇 |
特种医学 | 188篇 |
外国民族医学 | 1篇 |
外科学 | 2243篇 |
综合类 | 1383篇 |
现状与发展 | 1篇 |
预防医学 | 297篇 |
眼科学 | 63篇 |
药学 | 625篇 |
5篇 | |
中国医学 | 170篇 |
肿瘤学 | 352篇 |
出版年
2024年 | 30篇 |
2023年 | 284篇 |
2022年 | 527篇 |
2021年 | 571篇 |
2020年 | 502篇 |
2019年 | 455篇 |
2018年 | 431篇 |
2017年 | 304篇 |
2016年 | 472篇 |
2015年 | 528篇 |
2014年 | 975篇 |
2013年 | 877篇 |
2012年 | 697篇 |
2011年 | 757篇 |
2010年 | 655篇 |
2009年 | 565篇 |
2008年 | 548篇 |
2007年 | 547篇 |
2006年 | 433篇 |
2005年 | 353篇 |
2004年 | 269篇 |
2003年 | 214篇 |
2002年 | 162篇 |
2001年 | 150篇 |
2000年 | 116篇 |
1999年 | 103篇 |
1998年 | 75篇 |
1997年 | 71篇 |
1996年 | 75篇 |
1995年 | 51篇 |
1994年 | 49篇 |
1993年 | 32篇 |
1992年 | 33篇 |
1991年 | 30篇 |
1990年 | 38篇 |
1989年 | 27篇 |
1988年 | 29篇 |
1987年 | 25篇 |
1986年 | 20篇 |
1985年 | 11篇 |
1984年 | 13篇 |
1983年 | 10篇 |
1982年 | 15篇 |
1981年 | 7篇 |
1980年 | 9篇 |
1979年 | 6篇 |
1978年 | 8篇 |
1977年 | 9篇 |
1976年 | 6篇 |
1973年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
Kevin Kyung Ho Choi Santosh Sanagapalli 《World journal of gastrointestinal oncology》2022,14(3):568-586
Barrett's esophagus (BE) is the precursor to esophageal adenocarcinoma (EAC). Progression to cancer typically occurs in a stepwise fashion through worsening dysplasia and ultimately, invasive neoplasia. Established EAC with deep involvement of the esophageal wall and/or metastatic disease is invariably associated with poor long-term survival rates. This guides the rationale of surveillance of Barrett’s in an attempt to treat lesions at an earlier, and potentially curative stage. The last two decades have seen a paradigm shift in management of Barrett’s with rapid expansion in the role of endoscopic eradication therapy (EET) for management of dysplastic and early neoplastic BE, and there have been substantial changes to international consensus guidelines for management of early BE based on evolving evidence. This review aims to assist the physician in the therapeutic decision-making process with patients by comprehensive review and summary of literature surrounding natural history of Barrett’s by histological stage, and the effectiveness of interventions in attenuating the risk posed by its natural history. Key findings were as follows. Non-dysplastic Barrett’s is associated with extremely low risk of progression, and interventions cannot be justified. The annual risk of cancer progression in low grade dysplasia is between 1%-3%; EET can be offered though evidence for its benefit remains confined to highly select settings. High-grade dysplasia progresses to cancer in 5%-10% per year; EET is similarly effective to and less morbid than surgery and should be routinely performed for this indication. Risk of nodal metastases in intramucosal cancer is 2%-4%, which is comparable to operative mortality rate, so EET is usually preferred. Submucosal cancer is associated with nodal metastases in 14%-41% hence surgery remains standard of care, except for select situations. 相似文献
4.
《Revista brasileira de otorrinolaringologia (English ed.)》2022,88(4):602-606
IntroductionThe Modena bleeding score is a categorical rating scale that allows the assessment of the surgical field in relation to bleeding during endoscopic surgery. It has recently been presented and validated in the field of endoscopic ear surgery by the present authors. The Modena bleeding score provides five grades for rating the surgical field during endoscopic procedures (from grade 1 ? no bleeding to grade 5 ? bleeding that prevents every surgical procedure except those dedicated to bleeding control).ObjectiveThe aim of this study was to validate the Modena bleeding score in the setting of endoscopic sinus surgery.MethodsFifteen three-minute videos of endoscopic sinus surgery procedures (each containing three bleeding situations) were evaluated by 15 specialists, using the Modena bleeding score. Intra and inter-rater reliability were assessed, and the clinical validity of the Modena bleeding score was calculated using a referent standard.ResultsThe data analysis showed an intra-rater reliability ranging from 0.6336 to 0.861. The inter-rater reliability ranged from 0.676 to 0.844. The clinical validity was α = 0.70; confidence limits: 0.64 ? 0.75, corresponding to substantial agreement.ConclusionThe Modena bleeding score is an effective method to score bleeding during endoscopic sinus surgery. Its application in future research could facilitate the performance and efficacy assessment of surgical techniques, materials or devices aimed to bleeding control during endoscopic sinus surgery. 相似文献
5.
6.
7.
8.
9.
10.
Regan E. Giesinger Adrianne R. Bischoff Patrick J. McNamara 《Congenital heart disease》2019,14(2):311-316
Ligation of a hemodynamically significant ductus arteriosus results in significant changes in loading conditions which have predictable consequences. Postligation cardiac syndrome, defined as hypotension requiring inotropic support and failure of oxygenation and ventilation, may occur 6‐12 hours following ligation due to left ventricular systolic and diastolic failure, respectively. Afterload is the primary driver of this decompensation. In this review, we describe the pathophysiological changes in loading conditions associated with postligation cardiac syndrome and other contributors to cardiovascular dysfunction following ductal ligation. We present strategies for perioperative optimization and a physiology‐based algorithm for postoperative management guided by targeted neonatal echocardiography. The use of these strategies to reduce the frequency of postligation deterioration may be an avenue to improve outcomes for neonates in this vulnerable patient population. 相似文献