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排序方式: 共有251条查询结果,搜索用时 31 毫秒
1.
目的 采用脑磁图(magnetoencephalograph,MEG)的等价电流偶极子定位法(Equivalent current dipole,ECD)和合成孔径磁场定位法(SAMSynthetic、Aperture Magnetometry,SAM)定位母语为汉语的健康自愿者的语占中枢,探讨汉字的语言处理过程。方法 对10例母语为汉语的健康受试者给予默读真词、假词的语言任务刺激,记录刺激后产生的诱发磁场,将采集的数据与MRI叠加获得磁源性影像(MSI Magnetic source imaging)语占功能区定位川同样的方法对4例胶质瘤患者进行术前语言功能区定位,术中皮层电刺激所定位语言功能区,明确是否产生言语障碍。结果 所有受试者真词、假词均在双侧大脑半球诱发出明显的晚期磁反应波,左侧大脑半球磁反应波分化较右侧大脑半球好,Broea区俯于额下回后部,Wernicke区位于颞中同、颢上回、缘上回,Wernieke区先于Broca区出现。胶质瘤患者术巾电刺激所定位的Broca区、Wernicke区均产生言语障碍:结论母语为汉语的正常人的Broca区Wernieke区与经典的语言中枢糕本相符,MEG定位语言中枢的技术是可行的。 相似文献
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Kasturi Sanyal Mita Chatterjee Debnath 《Journal of labelled compounds & radiopharmaceuticals》2012,55(7):258-263
Protection of the thiolate function of dimercaptosuccinic acid (DMSA) and ethylenedi‐l ‐cysteine diethyl ester (ECD) by S‐thiomethylation allowed automatic deprotection during technetium‐99m (99mTc) radiolabelling by direct reduction with stannous chloride dihydrate. Protection of the free thiolate group increased the stability of the ligands as well as deprotection during complexation, which resulted in the desired radiopharmaceuticals. The complexes obtained from the protected ligands were chromatographically (HPLC) and biologically compared with the corresponding 99mTc complexes of the unprotected ligands. The results suggest that the aforementioned method of protection by S‐thiomethylation could be utilized for the development of single‐vial DMSA and ECD kit. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
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Early childhood development (ECD) has received increasing attention in both developed and developing countries since the 1990s. In Japan, ECD facilities have pursued integrated practices of education and health care to provide appropriate services to promote children’s welfare. This ECD approach appears to embody objectives of health promotion in young children. Therefore, information about Japanese practices may help to support ECD in other countries, especially developing countries. In this context, the present study discussed the potential application of health‐related ECD practices in Japan for developing countries by reviewing an outline of Japanese ECD, along with a case study describing practices in ECD facilities in Japan. We identified four main points: (i) distinct legal grounds including a legal basis for allocating health specialists; (ii) outlines of activities based on national standards and flexible practices at the facility level; (iii) teachers’ attitudes that respect children’s initiative, and explicit and independent activities embedded in children’s daily lives that reflect the child’s developmental status; and (iv) various useful practices to enhance the effect of health‐related activities, such as cooperation with parents, lesson study and hoiku‐ (teachers) conference. As these practices are based on the Japanese context, it is essential to consider both the Japanese context and potential risks of transplanting such concepts, to enable optimum use of these lessons in other countries. 相似文献
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《药学学报(英文版)》2019,9(3):545-556
Screening active natural products, rapid identification, and accurate isolation are of great important for modern natural lead compounds discovery1. We hereby reported the isolation of seven new neotecleanin-type limonoids (17), seven new limonoids with 5-oxatricyclo[5.4.0.11., 4.]hendecane ring system (814), and two new precursors (1516) together with four known limonoids (1720) from the root barks of Walsura robusta. Their structures, including their absolute configurations, were elucidated based on analyses of HR-ESI-MS, 1D/2D NMR, ECD spectrum calculations and single-crystal X-ray diffraction techniques. Compounds 2, 8, 9, 11, 13, 14, 18 showed significant anti-inflammatory activities in LPS-induced RAW 264.7 cell line, BV2 microglial cells, and Propionibacterium acnes-stimulated THP-1 human monocytic cells. Walrobsin M (11) exhibited anti-inflammatory activity with IC50 value of 7.96±0.36 μmol/L, and down-regulated phosphorylation levels of ERK and p38 in a dose-dependent manner. 相似文献
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Xiaoyun Qian Xiaofeng Ma Han Zhou Chenjie Yu Yifen Zhang Xia Yang 《Acta oto-laryngologica》2016,136(7):722-728
Conclusion: Down-regulation of ECD may associate with infiltrative tumor growth and result in poor prognosis. However, ECD expression is not significantly associated with tumor metastasis. Aim: To investigate the prognostic role of E-cadherin (ECD) expression in laryngeal cancer. Methods: In a clinical study, a total of 79 laryngeal cancer patients who received surgery were included in this study. The expression of ECD in laryngeal cancer tissue was detected by immumohistochemical staining. In an in vitro study, ECD up-regulated cells (Ad-ECD) and ECD down-regulated cells (sh-ECD) were cultured, along with interference by siRNA. Cell apoptosis was detected by flow cytometry. In an in vivo study, nude mice were injected with Ad-ECD, sh-ECD, and Hep-2 cells. The ECD expression and tumor metastasis in the brain, liver, and lung tissues were detected. Results: Clinical data showed that expression of ECD was statistically correlated with survival rate (p?<?0.05), but not with other clinical characteristics, such as age, gender, lymphatic metastasis, and TNM staging. ECD was down-regulated in sh-ECD cells and the down-regulation significantly reduced apoptosis of Hep-2 cells. Tumor growth was significantly inhibited in the Ad-ECD group. Except the tumor tissue, no positive ECD expression or significant tumor cells were found in the brain, liver, and lung tissues. 相似文献
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目的 建立用五氟苄基溴(PFB-Br)衍生气相色谱法,电子捕获检测器(ECD)定量测定唾液中氰离子(CN-)的方法。方法 取微量唾液,加入缓冲溶液后用乙腈稀释定容,加入定量的PFB-Br摇匀,沸水浴30.0 min进行衍生反应,冷却后直接进样入气相色谱仪分离,以ECD检测器检测。结果 唾液中CN-的质量浓度在0.25~200.0 mg/L呈线性关系,线性相关系数为0.999 4;以100.0 μl唾液量计算,方法最低检出浓度为0.07 mg/L,最低定量浓度为0.25 mg/L;方法的批间精密度为2.4%~5.3%(n=6),批内精密度为1.1%~3.8%(n=6),加标回收率为100.7%~102.1%。唾液常见的无机离子Cl-、F-和SCN-对测定结果均无干扰。样品可在4 ℃保存至少15 d。结论 该方法适用于唾液中氰离子测定,对氰化物中毒的应急检测有应用价值。 相似文献
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Concordance between 99mTc‐ECD SPECT and 18F‐FDG PET interpretations in patients with cognitive disorders diagnosed according to NIA‐AA criteria 下载免费PDF全文
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目的 用SPECT技术探讨脑出血患者治疗前后继发性缺血灶局部脑血流的变化及临床意义.方法 60例脑出血患者随机分为尼莫地平组与常规治疗组,在治疗前后用SPECT显像观察原发灶缺血体积、血肿周围及脑部其他区域的脑血流灌注减低区变化.结果 尼莫地平组和常规治疗组治疗后原发灶缺血体积明显缩小,前者比后者更明显;原发灶及远隔部位缺血灶局部脑血流增加值尼莫地平组明显高于常规治疗组(P<0.01).结论 SPECT脑血流灌注显像可灵敏地反映治疗前后局部脑血流变化,可用于药物疗效评价. 相似文献