全文获取类型
收费全文 | 592篇 |
免费 | 8篇 |
专业分类
儿科学 | 11篇 |
妇产科学 | 1篇 |
基础医学 | 207篇 |
口腔科学 | 2篇 |
临床医学 | 121篇 |
内科学 | 16篇 |
神经病学 | 41篇 |
特种医学 | 38篇 |
外科学 | 100篇 |
综合类 | 20篇 |
预防医学 | 18篇 |
眼科学 | 1篇 |
药学 | 3篇 |
中国医学 | 11篇 |
肿瘤学 | 10篇 |
出版年
2023年 | 5篇 |
2022年 | 16篇 |
2021年 | 16篇 |
2020年 | 12篇 |
2019年 | 18篇 |
2018年 | 21篇 |
2017年 | 9篇 |
2016年 | 7篇 |
2015年 | 14篇 |
2014年 | 31篇 |
2013年 | 37篇 |
2012年 | 11篇 |
2011年 | 25篇 |
2010年 | 18篇 |
2009年 | 27篇 |
2008年 | 33篇 |
2007年 | 26篇 |
2006年 | 33篇 |
2005年 | 28篇 |
2004年 | 31篇 |
2003年 | 18篇 |
2002年 | 21篇 |
2001年 | 12篇 |
2000年 | 12篇 |
1999年 | 13篇 |
1998年 | 11篇 |
1997年 | 9篇 |
1996年 | 6篇 |
1995年 | 9篇 |
1994年 | 8篇 |
1993年 | 6篇 |
1992年 | 6篇 |
1991年 | 7篇 |
1990年 | 5篇 |
1989年 | 4篇 |
1988年 | 3篇 |
1987年 | 9篇 |
1986年 | 3篇 |
1985年 | 2篇 |
1984年 | 5篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1978年 | 1篇 |
1977年 | 3篇 |
1971年 | 2篇 |
排序方式: 共有600条查询结果,搜索用时 14 毫秒
1.
《JACC: Cardiovascular Interventions》2022,15(12):1205-1215
BackgroundDistal radial access (DRA) has been proposed to improve procedure ergonomics and favor radial artery patency. Although promising data, nothing is known on evolving hand function after DRA.ObjectivesThis study sought to comprehensively evaluate hand function in patients undergoing DRA.MethodsReal-world patients undergoing DRA undertook a thorough multimodality assessment of hand function implementing multidomain questionnaires (Disabilities of the Arm, Shoulder and Hand and Levine-Katz), and motor (pinch grip test) and sensory (Semmes-Weinstein monofilaments test) examinations of both hands. All assessments were performed at preprocedural baseline and planned at 1-, 6-, and 12-month follow-up (FU). Adverse clinical and procedural events were documented too.ResultsData of 313 patients (220 men, age 66 ± 10 years) from 9 international centers were analyzed. The Disabilities of the Arm, Shoulder and Hand and the Levine-Katz scores slightly improved from baseline to FU (P = 0.008 and P = 0.029, respectively). Pinch strength mildly improved from baseline to FU (P < 0.001 for both the left and right hands). Similarly, touch pressure threshold appeared to faintly improve in both the left and right hands (P < 0.012 for all the sites). For both motor and sensory function tests, comparable findings were found for the DRA hand and the contralateral one, with no significant differences between them. Repeated assessment of all tests over all FU time points similarly showed lack of worsening hand function. Access-related adverse events included 19 harmless bleedings and 3 forearm radial artery and 3 distal radial artery occlusions. None affected hand function at FU.ConclusionsIn a systematic multidimensional assessment, DRA was not associated with hand function impairment. Moreover, DRA emerges as a safe alternative vascular access. 相似文献
2.
Andor Erdelyil Teuvo Sihvonen Pertti Helin Osmo Hänninen 《International archives of occupational and environmental health》1988,60(2):119-124
Summary Keyboard work consists mostly of dynamic contractions of the small muscles of the forearms and hands. This is accompanied by continuous activity in the arm, shoulder and neck muscles keeping the head and hand in the correct position. Eliminating the weight from the arm by means of support and the position of the arms influences the electrical activity of shoulder muscles when working at a keyboard. We studied the influence of elbow angle, as well as that of different arm supports, on electrical activity of upper trapezius muscle during keyboard work in healthy workers and persons suffering from shoulder pains. The measurements were carried out in the laboratory. EMG activities, which where measured as mean square root (RMS)-values at every 100-millisecond period in trapezius muscle when working, were lower, the greater the elbow angle. Furthermore electrical activity decreased when subjects used arm supports while working. It is evident that the static load to shoulder muscles can be lowered significantly in keyboard work, when the forearms are at an angle of at least 100 degrees and by using arm supports. The most convienient and ergonomic working position can also be found individually be the method used here. 相似文献
3.
Zehr EP Haridas C 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2003,149(2):260-266
Stimulation of cutaneous nerves innervating the hand evokes prominent reflexes in many arm muscles during arm cycling. We
hypothesized that the mechanisms controlling reflex modulation during the rhythmic arm swing of walking would be similar to
that documented during arm cycling. Thus, we expected cutaneous reflexes to be modulated by position in the walking cycle
(phase dependence) and be different when walking compared to contraction while standing (task dependence). Subjects performed
static postures similar to those occurring during walking and also walked on a treadmill while the superficial radial nerve
was electrically stimulated pseudorandomly throughout the step cycle. EMG was recorded bilaterally from upper limb muscles
and kinematic recordings were obtained from the elbow and shoulder joints. Step cycle information was obtained from force-sensing
insoles. Analysis was conducted after averaging contingent upon the occurrence of stimulation in the step cycle. Phase-dependent
modulation of cutaneous reflexes at early (~50–80 ms) and middle (~80–120 ms) latencies was observed. Coordinated bilateral
reflexes were seen in posterior deltoid and triceps brachii muscles. Task dependency was seen in that reflex amplitude was
only correlated with background EMG during static contraction (75% of comparisons for both early and middle latency reflexes).
During walking, no significant relationship between reflex amplitude and background EMG level was found. The results show
that cutaneous reflex modulation during rhythmic upper limb movement is similar to that seen during arm cycling and to that
observed in leg muscles during locomotion. These results add to the evidence that, during cyclical movements of the arms and
legs, similar neural mechanisms observed only during movement (e.g. central pattern generators) control reflex output.
Electronic Publication 相似文献
4.
The purposes of this study were to apply the linear power versus inverse of time relationship to high-intensity upper-body
exercise and to assess the repeatability of the parameters critical power (CP) and anaerobic working capacity (AWC), using
limits of agreement (Bland and Altman 1986). Sixteen active male subjects (aged 20–34 years), performed two sets of five constant-power
exercises on an adapted cycle ergometer. There were no significant differences between mean estimates of CP [96 (16) W and
95 (17) W] and AWC [7457 (2011) J and 7608 (1684) J] from the first and second sets of bouts. Despite the lack of systematic
bias, there was evidence of large random error. Ratio limits of agreement for time to exhaustion during constant-power exercises
suggested that a repeat measurement might be expected in 95% of cases to be between 0.64 and 1.59 times the original measurement.
The 95% limits of agreement for CP were –15 W to +17 W. The ratio limits of agreement for AWC suggest that in 95% of cases
a repeat measurement might be between 0.57 and 1.67 times the original estimate. The results of this study suggest a poor
repeatability of constant-power upper-body exercises to exhaustion, which may contribute to a poor repeatability of CP and
AWC determined from the linear power versus inverse of time model.
Electronic Publication 相似文献
5.
Poljac E van den Berg AV 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2003,151(4):501-513
Manipulation of objects around the head requires an accurate and stable internal representation of their locations in space, also during movements such as that of the eye or head. For far space, the representation of visual stimuli for goal-directed arm movements relies on retinal updating, if eye movements are involved. Recent neurophysiological studies led us to infer that a transformation of visual space from retinocentric to a head-centric representation may be involved for visual objects in close proximity to the head. The first aim of this study was to investigate if there is indeed such a representation for remembered visual targets of goal-directed arm movements. Participants had to point toward an initially foveated central target after an intervening saccade. Participants made errors that reflect a bias in the visuomotor transformation that depends on eye displacement rather than any head-centred variable. The second issue addressed was if pointing toward the centre of a wide-field expanding motion pattern involves a retinal updating mechanism or a transformation to a head-centric map and if that process is distance dependent. The same pattern of pointing errors in relation to gaze displacement was found independent of depth. We conclude that for goal-directed arm movements, representation of the remembered visual targets is updated in a retinal frame, a mechanism that is actively used regardless of target distance, stimulus characteristics or the requirements of the task. 相似文献
6.
Nikolaos Smyrnis Masato Taira James Ashe Apostolos P. Georgopoulos 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1992,92(1):139-151
Summary Two rhesus monkeys were trained to move a handle on a two-dimensional (2D) working surface in directions specified by a light at the plane. They first captured with the handle a light on the center of the plane and then moved the handle in the direction indicated by a peripheral light (cue signal). The signal to move (go signal) was given by turning off the center light. The following tasks were used: (a) In the non-delay task the peripheral light was turned on at the same time as the center light went off. (b) In the memorized delay task the peripheral light stayed on for 300 ms and the center light was turned off 450–750 ms later. Finally, (c) in the non-memorized delay task the peripheral light stayed on continuously whereas the center light went off 750–1050 ms after the peripheral light came on. Recordings in the arm area of the motor cortex (N= 171 cells) showed changes in single cell activity in all tasks. In both delay tasks, the neuronal population vector calculated every 20 ms after the onset of the peripheral light pointed in the direction of the upcoming movement, which was instructed by the cue light. Moreover, the strength of the population signal showed an initial peak shortly after the cue onset in both the memorized and non-memorized delay tasks but it maintained a higher level during the memorized delay period, as compared to the non-memorized task. These results indicate that the motor cortex is involved in encoding and holding in memory directional information concerning a visually cued arm movement and that these processes can be visualized using neuronal population vector analysis. 相似文献
7.
Kazutoshi Kudo T. Ohtsuki 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1998,122(1):23-30
Subjects made a fast elbow extension movement to designated target in response to a go signal. In 45% of trials a stop signal
was presented after the go signal, to which subjects were asked to stop the movement as rapidly as possible. The interstimulus
interval (ISI), or time interval between the go and stop signals, was randomly varied between 0 and 200 ms. Electromyographic
(EMG) activity was recorded from biceps brachii and triceps brachii. Subjects could sometimes completely inhibit initiation
of the movements when the ISI was 0 ms, but could rarely do so when the ISI exceeded 100 ms. For responses that were initiated
but stopped on the way, the amplitude of the movement decreased linearly as the time interval (=modification time) from the
stop signal to EMG onset increased. The peak velocity increased linearly as the movement amplitude increased. This tendency
was similar to those previously reported in step-tracking movements with various amplitudes. In spite of the similarity in
the kinematics of the movement, the EMG pattern was different from that of step-tracking movement. While the initial agonist
burst (AG1) decreased linearly after the modification time exceeded 100 ms, the antagonist burst (ANT) increased compared
with the go trial for the modification time from 0 to 200 ms and decreased after the modification time exceeded 300 ms. This
change of activation is analogous to functional modification of middle-latency reflex EMG response to load, or cutaneous perturbation.
In conclusion, it is suggested that adaptive mechanisms, which would functionally modify the reflex responses, are also continuously
working during voluntary movements in response to sudden changes in environmental information.
Received: 3 November 1997 / Accepted: 3 February 1998 相似文献
8.
Milner TE 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2004,159(2):172-184
This study investigated the ability to use an internal model of the environmental dynamics when the dynamics were predictable but unstable. Subjects performed goal-directed movements using a robot manipulandum while counteracting a force field, which created instability by assisting the movement in proportion to hand velocity. Subjects performance was better on the last trial than on the first trial in the force field for all four movement directions tested: out, in, right and left. Subjects adapted to the force field primarily by increasing muscle co-contraction, compared to null field movements, during all phases of movement. This co-contraction generally declined for both the deceleration and stabilization phases during the course of the first 25 movements in each direction, but tended not to decrease significantly thereafter. Catch trials at the end of the learning period suggested that increased viscoelastic impedance due to muscle co-contraction was used to counteract the force field. Only in the case of outward movements were aftereffects observed that were consistent with formation of an accurate internal model of the force field dynamics. Stabilization of the hand for outward movements required less muscle co-contraction than for movements in other directions due to stability conferred by the geometry of the arm. The results suggest that the accuracy of an internal model depends critically on the stability of the coupled dynamics of the limb and the environment. 相似文献
9.
Lai EJ Hodgson AJ Milner TE 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2003,153(1):76-83
Studies have shown that the point-to-point reaching movements of subjects seated in a dark, rotating room demonstrate errors in movement trajectories and endpoints, consistent with the direction of the Coriolis force perturbations created by room rotation. Adaptation of successive reaches and the presence of postrotation aftereffects have indicated that subjects form internal models of the Coriolis field dynamics in order to make appropriate movement corrections. It has been argued that these findings are inconsistent with predictions of peripheral stabilization assumed in equilibrium-point models of motor control. A possibility that has been raised, however, is that the Coriolis field findings may in fact stem from changes in control commands elicited due to the magnitude and destabilizing nature of the Coriolis perturbations. That is, it has been suggested that a perturbation threshold exists, below which central reactions are not necessary in order to maintain movement stability. We tested the existence of a perturbation threshold in normal-speed reaching movements. Twelve normal human subjects performed non-visually guided reaching movements while grasping a robotic manipulandum. The endpoints and trajectory deviations of their movements were measured before, during, and after a position-dependent force field (similar to a Coriolis field in terms of the time history of applied forces) was applied to their movements. We examined the responses to a range of perturbation field strengths from small to considerable. Our experimental results demonstrated a substantial adaptation response over the entire range of perturbation field magnitudes examined. Neither the amount of adaptation after 5 trials nor after 25 trials was found to change as disturbance magnitudes decreased. These findings indicate that there is an adaptive response even for small perturbations; i.e., threshold behavior was not found. This result contradicts the assertion that peripheral stabilization mechanisms enable the central controller to ignore small details of peripheral or environmental dynamics. Our findings instead point to a central dynamic modeler that is both highly sensitive and continually active. The results of our study also showed that subjects were able to maintain baseline pointing accuracies despite exposure to perturbation forces of sizeable magnitude (more than 7 N). 相似文献
10.
Lauren E. Sergio David J. Ostry 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1995,105(1):123-137
The present study quantifies electromyographic (EMG) magnitude, timing, and duration in one and two degree of freedom elbow movements involving combinations of flexion-extension and pronation-supination. The aim is to understand the organization of commands subserving motion in individual and multiple degrees of freedom. The muscles tested in this study fell into two categories with respect to agonist burst magnitude: those whose burst magnitude varied with motion in a second degree of freedom at the elbow, and those whose burst magnitude depended on motion in one degree of freedom only. In multiarticular muscles contributing to motion in two degrees of freedom at the elbow, we found that the magnitude of the agonist burst was greatest for movements in which a muscle acted as agonist in both degrees of freedom. The burst magnitudes for one degree of freedom movements were, in turn, greater than for movements in which the muscle was agonist in one degree of freedom and antagonist in the other. It was also found that, for movements in which a muscle acted as agonist in two degrees of freedom, the burst magnitude was, in the majority of cases, not different from the sum of the burst magnitudes in the component movements. When differences occurred, the burst magnitude for the combined movement was greater than the sum of the components. Other measures of EMG activity such as burst onset time and duration were not found to vary in a systematic manner with motion in these two degrees of freedom. It was also seen that several muscles which produced motion in one degree of freedom at the elbow, including triceps brachii (long head), triceps brachii (lateral head), and pronator quadratus displayed first agonist bursts whose magnitude did not vary with motion in a second degree of freedom. However, for the monoarticular elbow flexors brachialis and brachioradialis, agonist burst magnitude was affected by pronation or supination. Lastly, it was observed that during elbow movements in which muscles acted as agonist in one degree of freedom and antagonist in the other, the muscle activity often displayed both agonist and antagonist components in the same movement. It was found that, for pronator teres and biceps brachii, the timing of the bursts was such that there was activity in these muscles concurrent with activity in both pure agonists and pure antagonists. The empirical summation of EMG burst magnitudes and the presence in a single muscle of both agonist and antagonist bursts within a movement suggest that central commands associated with motion in individual degrees of freedom at the elbow may be superimposed to produce elbow movements in two degrees of freedom. 相似文献