全文获取类型
收费全文 | 29767篇 |
免费 | 3275篇 |
国内免费 | 567篇 |
专业分类
耳鼻咽喉 | 324篇 |
儿科学 | 595篇 |
妇产科学 | 392篇 |
基础医学 | 2082篇 |
口腔科学 | 9619篇 |
临床医学 | 2527篇 |
内科学 | 2464篇 |
皮肤病学 | 507篇 |
神经病学 | 846篇 |
特种医学 | 417篇 |
外国民族医学 | 1篇 |
外科学 | 1353篇 |
综合类 | 2452篇 |
现状与发展 | 4篇 |
一般理论 | 10篇 |
预防医学 | 3348篇 |
眼科学 | 112篇 |
药学 | 3612篇 |
33篇 | |
中国医学 | 1333篇 |
肿瘤学 | 1578篇 |
出版年
2024年 | 82篇 |
2023年 | 641篇 |
2022年 | 922篇 |
2021年 | 1310篇 |
2020年 | 1488篇 |
2019年 | 1472篇 |
2018年 | 1378篇 |
2017年 | 1324篇 |
2016年 | 1312篇 |
2015年 | 1300篇 |
2014年 | 1797篇 |
2013年 | 2454篇 |
2012年 | 1613篇 |
2011年 | 1696篇 |
2010年 | 1311篇 |
2009年 | 1229篇 |
2008年 | 1205篇 |
2007年 | 1178篇 |
2006年 | 1078篇 |
2005年 | 1028篇 |
2004年 | 863篇 |
2003年 | 819篇 |
2002年 | 703篇 |
2001年 | 619篇 |
2000年 | 499篇 |
1999年 | 415篇 |
1998年 | 397篇 |
1997年 | 420篇 |
1996年 | 322篇 |
1995年 | 289篇 |
1994年 | 271篇 |
1993年 | 207篇 |
1992年 | 237篇 |
1991年 | 185篇 |
1990年 | 168篇 |
1989年 | 183篇 |
1988年 | 133篇 |
1987年 | 125篇 |
1986年 | 115篇 |
1985年 | 98篇 |
1984年 | 94篇 |
1983年 | 76篇 |
1982年 | 89篇 |
1981年 | 85篇 |
1980年 | 66篇 |
1979年 | 48篇 |
1978年 | 40篇 |
1977年 | 61篇 |
1976年 | 45篇 |
1975年 | 35篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
《JACC: Cardiovascular Interventions》2022,15(7):741-750
ObjectivesThe aim of this study was to report 1-year clinical outcomes following commercial transcatheter left atrial appendage occlusion (LAAO) in the United States.BackgroundThe National Cardiovascular Data Registry LAAO Registry was initiated to meet a condition of Medicare coverage and allow the assessment of clinical outcomes. The 1-year rates of thromboembolic events after transcatheter LAAO in such a large cohort of “real-world” patients have not been previously reported.MethodsPatients entered into the National Cardiovascular Data Registry LAAO Registry for a Watchman procedure between January 1, 2016, and December 31, 2018, were included. The primary endpoint was ischemic stroke. Key secondary endpoints included the rate of ischemic stroke or systemic embolism, mortality, and major bleeding. Major bleeding was defined as any bleeding requiring hospitalization, and/or causing a decrease in hemoglobin level > 2g/dL, and/or requiring blood transfusion that was not hemorrhagic stroke. The Kaplan-Meier method was used for 1-year estimates of cumulative event rates.ResultsThe study population consisted of 36,681 patients. The mean age was 76.0 ± 8.1 years, the mean CHA2DS2-VASc score was 4.8 ± 1.5, and the mean HAS-BLED score was 3.0 ± 1.1. Prior stroke was present in 25.5%, clinically relevant bleeding in 69.5%, and intracranial bleeding in 11.9%. Median follow-up was 374 days (IQR: 212-425 days). The Kaplan-Meier–estimated 1-year rate of ischemic stroke was 1.53% (95% CI: 1.39%-1.69%), the rate of ischemic stroke or systemic embolism was 2.19% (95% CI: 2.01%-2.38%), and the rate of mortality was 8.52% (95% CI: 8.19%-8.87%). The 1-year estimated rate of major bleeding was 6.93% (95% CI: 6.65%-7.21%). Most bleeding events occurred between discharge and 45 days following the procedure.ConclusionsThis study characterizes important outcomes in a national cohort of patients undergoing transcatheter LAAO in the United States. Clinicians and patients can integrate these data in shared decision making when considering this therapy. 相似文献
2.
3.
Is it possible to make a diagnosis of raw,heated, and baked egg allergy in children using cutoffs? A systematic review 下载免费PDF全文
4.
Interaction effects between the 5‐hydroxy tryptamine transporter‐linked polymorphic region (5‐HTTLPR) genotype and family conflict on adolescent alcohol use and misuse 下载免费PDF全文
5.
6.
《BJU international》2006,98(Z2):9-12
The tamsulosin oral‐controlled absorption system (OCAS®) is a new tablet formulation of the α1‐adrenoceptor (α1‐AR) antagonist tamsulosin, which is used for treating lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH). The tablet uses the OCAS technology, which was specifically designed to give a more continuous 24‐h release of tamsulosin, resulting in a more consistent and continuous 24‐h plasma concentration, a lower maximum plasma concentration (Cmax) and an independence of pharmacokinetics (PKs) on food intake. It was expected that the improved PK profile would translate into a better control of day‐ and night‐time symptoms of BPH and a lower risk of adverse events. Phase I PK studies showed that tamsulosin OCAS indeed has a flattened PK profile with a lower Cmax and a more stable and consistent 24‐h concentration of tamsulosin, independent of food intake, compared to conventional tamsulosin. A study combining γ‐scintigraphy and PK analysis of blood samples confirmed that the improved PK profile of tamsulosin OCAS is attributed to the tablet being consistently and continuously released throughout the entire gastrointestinal tract, including the colon. 相似文献
7.
Kenji Fujisawa Youji Miyamoto Masaru Nagayama 《Journal of oral pathology & medicine》2003,32(6):358-366
BACKGROUND: The therapies for refractory ulcers on the oral mucosa are symptomatic and very unsatisfactory. We hypothesized that application of growth factors might be able to achieve successful remission of the lesion. We evaluated the effects of systemic administration and topical application of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) on impaired wound healing of ulcers in the rabbit gingiva. METHODS: Almost uniform round ulcers could be created on the gingiva of the rabbits by chemical injury with acetic acid. When the submandibular glands were removed or i.v. injection of cisplatin (CDDP) and peplomycin sulfate was performed before ulcer formation, healing of the ulcers took longer than in untreated rabbits. To ascertain whether or not human EGF and bFGF affect rabbit cells, we first examined the effects of EGF and bFGF on the proliferation of the cells derived from rabbit gingiva. We then applied EGF or bFGF in these impaired healing models. RESULTS: EGF and bFGF promoted proliferation of the fibroblasts, and EGF also promoted proliferation of the keratinocytes isolated from gingival tissue of rabbits in vitro. Systemic injections of EGF and bFGF in rabbits, which had their submandibular glands removed, and topical application of bFGF accelerated healing of ulcers created in rabbits injected with CDDP and peplomycin sulfate. The ability of bFGF to promote the healing of ulcers was much greater than that of EGF. CONCLUSION: Basic FGF may be effective for refractory oral mucosal lesions. 相似文献
8.
Mariela Dutra Gontijo Moura Soraya de Mattos Camargo Grossmann Linaena Méricy da Silva Fonseca Maria Inês Barreiros Senna Ricardo Alves Mesquita 《Journal of oral pathology & medicine》2006,35(6):321-326
BACKGROUND: Oral hairy leukoplakia (OHL) may be an indicator of the progression of Human Immunodeficiency Virus (HIV)-induced immuno-depression, and the evaluation of risk factors leading to OHL is important in the management of these HIV-infected patients. However, there are few studies that analyze risk factors leading to OHL in the Brazilian population. The aim of this case-control study is to present data about prevalence rates and risk factors leading to OHL in a sample of HIV-infected adults in Brazil. METHODS: This case-control study included 111 HIV-infected patients treated at a clinic for sexually transmitted diseases and HIV. In the initial examinations with dentists, variables were collected from all patients. Diagnosis of OHL was performed in accordance with the International Classification System and cytological features. The Fisher and the chi-squared tests were used for statistical analysis. The proportional prevalence and odds ratio were estimated. RESULTS: Outcome presented a positive, statistically significant association among the presence of OHL and viral load of 3000 copies/mul or greater (P = 0.0001; odds ratio (OR) = 5.8), presence of oral candidiasis (P = 0.0000; OR = 11.1), previous use of fluconazole (P = 0.0000; OR = 24.6), and use of systemic acyclovir (P = 0.032; OR = 4.3). Antiretroviral medication presented a negative, statistically significant association with the presence of OHL (P = 0.002; OR = 8.4). CONCLUSIONS: Prevalence of OHL was 28.8%. Viral load, oral candidiasis, previous use of fluconazole, and systemic acyclovir were determined to be risk factors for OHL. Antiretroviral medication proved to be protective against the development of OHL. 相似文献
9.
目的 :通过对平阳霉素术前化疗效果的相关因素分析 ,早期判断平阳霉素对口腔鳞癌的效果 ,为确定进一步治疗方案提供指导。方法 :对本院近 3年来接受平阳霉素 (总量为 80mg)化疗的 4 3例口腔癌患者进行直线相关和回归分析 ,观察化疗期间体温改变、发热持续时间、胃肠道反应时间及WBC改变与疗效的关系。结果 :①接受平阳霉素化疗有效的患者多在第 3~ 6天出现局部反应 ;②发热的程度及胃肠道反应与化疗效果密切相关 (P<0 .0 5 )。结论 :化疗早期出现的发热、胃肠道症状及局部反应可以作为早期判断预期疗效的方法。 相似文献
10.
Oral allergy syndrome induced by spinach 总被引:1,自引:1,他引:0
I. Sanchez F. Rodriguez J. L. Garcia-Abujeta L. Fernandez D. Quiñones D. Martin-Gil 《Allergy》1997,52(12):1245-1246