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孙保祥 《山东医大基础医学院学报》2004,18(6):342-343
目的:探讨口腔径路曲安奈德蝶腭神经节封闭治疗变应性鼻炎的效果。方法:变应性鼻炎患者415例,男270例,女145例。用自制封闭针头于口腔径路行曲安奈德蝶腭神经节封闭术。结果:415例中,有效250例,好转63例,总有效率为99.5%。结论:经口腔径路用曲安奈德行蝶腭神经节封闭术是治疗变应性鼻炎的有效疗法。 相似文献
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采用一阶导数分光光度法测定醋酸曲安缩松注射液的含量,平均回收率为99.82%,RSD为0.39%。方法简便快速,结果满意。 相似文献
4.
目的:观察和总结瘤内注射治疗颌面部血管瘤的疗效。方法:采用醋酸曲安奈德注射液加平阳霉素局部注射治疗婴幼儿颌面部血管瘤,如一次注射治疗未愈的,间隔4~6周重复给药,4次为一个疗程,醋酸曲安奈德总量不超过100mg,平阳霉素总量不超过40mg;观察肿瘤消退情况。结果:84例患儿,经1年随访,治愈率(90.4%),显效率(7.1%),无效率(2.4%)。结论:本方法疗效可靠、副作用小、外观较满意,适合婴幼儿颌面部血管瘤的治疗。 相似文献
5.
Diane J. Pincus MD Teresa R. Humeston BS Richard J. Martin MD 《The Journal of allergy and clinical immunology》1997,100(6):771-774
Background: Chronotherapy studies with inhaled corticosteroids have shown optimal therapeutic benefit when steroids are administered four times per day (QID) or once daily at 3 PM.Objective: This study evaluated whether more convenient once-daily dosage times (8 AM and 5:30 PM) produce improvement in asthma equivalent to QID.Methods: Efficacy outcome measures included FEV1, peak expiratory flow rates, bronchial responsiveness, use of β2-agonists, nocturnal awakenings, and responses to a quality of life questionnaire. Systemic effects were blood eosinophil count, cortisol level, 24-hour urinary cortisol, and evaluation for oral candidiasis and dysphonia.Results: Baseline measurements for all three treatment groups were similar. For morning peak expiratory flow rate, significant improvement was seen for the QID group (p = 0.001) and the 5:30 PM group (p = 0.003), but not the 8 AM group (p = 0.75). For evening peak expiratory flow rate, significant improvement was seen for the QID group (p = 0.005) and the 5:30 PM group (p = 0.01), but not for the 8 AM group (p = 0.47). There were significant improvements in all other outcome variables for each group except PC20. There was a significant improvement in PC20 only in the QID group. The systemic effects of the three regimens were comparable.Conclusion: Dosing of inhaled steroid at 5:30 PM had no increased systemic effects and produced efficacy similar to QID dosing. Dosing at 8 AM did not produce results consistently comparable to QID dosing. Optimal once-daily dosing of inhaled steroid is between 3 PM and 5:30 PM. 相似文献
6.
BACKGROUND : Most published studies show that intranasal corticosteroids have no effect on the hypothalamic-pituitary-adrenal (HPA) axis, but there have been isolated reports to the contrary, contradicting accumulated knowledge on pharmacokinetics. OBJECTIVE : To re-evaluate the effect of fluticasone propionate aqueous nasal spray (FPANS) and triamcinolone acetonide (TAA) aqueous nasal spray on the HPA axis using an improved study design. METHODS : Twenty-three healthy volunteers were randomized in a double-blind, three-way crossover study. The study comprised a 4-day placebo run-in phase followed by three 4-day treatment periods (placebo, FPANS (200 microg once daily) or TAA aqueous nasal spray (220 microg once daily)), separated by 7-14 days washout intervals. Before the first, and on the last day of each treatment period, 12-h overnight urine was collected to assess cortisol excretion and cortisol creatinine ratio. Approximately 26 h after the last administration of study medication, volunteers underwent stimulation with 0.5 microg adrenocorticotropic hormone (ACTH). Serum cortisol concentrations were measured before and 20 and 30 min after injection. Blood and urine samples were analysed for cortisol by liquid chromatography tandem mass spectrometry. RESULTS : Compared with placebo, EP or TAA had no significant effect on mean overnight (12 h) urinary cortisol excretion, and did not significantly suppress the overnight geometric mean urinary cortisol/creatinine excretion ratio. Values for serum cortisol before and after ACTH simulation showed no significant suppression, although there was a slight blunting of the HPA-axis response following TAA treatment. CONCLUSION : This study confirms that there are no detectable effects on the HPA axis following short-term intranasal FP or TAA at their recommended dosages. 相似文献
7.
目的:观察局部注射药物与口服药治疗三叉神经痛的疗效差异。方法:选择门诊三叉神经痛的患者,并随机分成两组,即口服药物组给予卡马西平100mg1-2次/天,若不能止痛每天增加100mg ,直到控制疼痛为止,将最小有剂量作为维持量,一般为600-800mg/d,共36例。局部药物注射组以4%氢羟强的松龙0.5ml加2%利多卡因1.5ml混合后准确地注射到罹患神经通过的骨孔处,共32例。结果:口服药物组6个月有效27例,有效率75%,局部药物注射组6个月有效30例,有效率94%。结论:局部药物注射组的疗效明显优于口服药物组。 相似文献
8.
目的 采用高效液相色谱法测定尿素醋酸曲安萘德软膏中醋酸曲安萘德的含量。方法 Kromasil C18(150mm×4.6mm,5μm)色谱柱;流动相为甲醇水乙醚(62∶38∶2);流量1.0ml·min-1;检测波长为240nm。采用炔诺酮作内标物质。结果 醋酸曲安萘德在0.16~0.79μg范围内呈线性关系,r=0.9998(n=5),平均回收率为100.7%(n=5),RSD为0.97%。结论 本法简便、准确,可以控制该制剂的质量。 相似文献
9.
目的:观察曲安奈德对增生性瘢痕的治疗效果.方法:对63例增生性瘢痕患者采用曲安奈德瘢痕内注射进行治疗.结果:治愈:39例;有效:18例;无效:6例.结论:曲安奈德是治疗增生性瘢痕的有效药物. 相似文献
10.
Safety & efficacy of single subconjunctival triamcinolone 5 mg depot vs topical loteprednol post cataract surgery: less drop cataract surgery
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Jagadeesh Kumar Reddy Vivek Chaitany Neeraj Shah Venkata Prabhakar Guduru Shadab Khan Siddharthan Kuttupalayam 《国际眼科》2019,12(5):774-778
AIM: To do a randomized prospective interventional study for comparing the effects of a single subconjunctival triamcinolone acetonide (SCTA) injection to tapering topical loteprednol in patients undergoing phacoemulsification surgery under topical anesthesia.
METHODS: A total of 400 patients were randomized into 2 groups; Group A (200 patients) received 5 mg SCTA at the end of surgery and topical ketorolac tromethamine (0.5%) with ofloxacin (0.3%) combination for 3wk. Group B (200 patients) received tapering topical loteprednol etabonate (0.5%) along with ofloxacin (0.3%) and ketorolac tromethamine (0.5%) for 3wk. Outcomes evaluated were intraocular pressure (IOP), anterior chamber cells/flare and macular oedema postoperatively at 1, 6 and 12wk.
RESULTS: Baseline parameters were almost similar in both the groups. No statistical difference was seen between the preoperative and postoperative IOP values for Group A (P=0.82) and Group B (P=0.61) and postoperative IOP values in between both groups (P=0.14) at 1wk. Incidence of cells/flare postoperative was statistically not significant (P=0.82) in both groups at all follow up visits. Postoperative macular oedema was not observed at any follow up visit.
CONCLUSION: SCTA appears to be an effective alternative to prolong postoperative topical steroid use. 相似文献