全文获取类型
收费全文 | 24354篇 |
免费 | 2047篇 |
国内免费 | 1463篇 |
专业分类
耳鼻咽喉 | 163篇 |
儿科学 | 436篇 |
妇产科学 | 368篇 |
基础医学 | 4339篇 |
口腔科学 | 364篇 |
临床医学 | 2290篇 |
内科学 | 4561篇 |
皮肤病学 | 401篇 |
神经病学 | 1147篇 |
特种医学 | 734篇 |
外国民族医学 | 12篇 |
外科学 | 2426篇 |
综合类 | 3667篇 |
现状与发展 | 6篇 |
预防医学 | 1060篇 |
眼科学 | 426篇 |
药学 | 2087篇 |
10篇 | |
中国医学 | 366篇 |
肿瘤学 | 3001篇 |
出版年
2024年 | 61篇 |
2023年 | 468篇 |
2022年 | 1000篇 |
2021年 | 1436篇 |
2020年 | 939篇 |
2019年 | 908篇 |
2018年 | 780篇 |
2017年 | 761篇 |
2016年 | 876篇 |
2015年 | 1014篇 |
2014年 | 1620篇 |
2013年 | 1511篇 |
2012年 | 1601篇 |
2011年 | 1691篇 |
2010年 | 1440篇 |
2009年 | 1541篇 |
2008年 | 1441篇 |
2007年 | 1397篇 |
2006年 | 1166篇 |
2005年 | 942篇 |
2004年 | 701篇 |
2003年 | 555篇 |
2002年 | 406篇 |
2001年 | 421篇 |
2000年 | 317篇 |
1999年 | 284篇 |
1998年 | 283篇 |
1997年 | 261篇 |
1996年 | 192篇 |
1995年 | 199篇 |
1994年 | 180篇 |
1993年 | 159篇 |
1992年 | 134篇 |
1991年 | 122篇 |
1990年 | 88篇 |
1989年 | 92篇 |
1988年 | 101篇 |
1987年 | 70篇 |
1986年 | 64篇 |
1985年 | 108篇 |
1984年 | 58篇 |
1983年 | 55篇 |
1982年 | 52篇 |
1981年 | 60篇 |
1980年 | 67篇 |
1979年 | 48篇 |
1978年 | 41篇 |
1977年 | 30篇 |
1976年 | 43篇 |
1973年 | 20篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
2.
《Molecular therapy》2022,30(8):2856-2867
- Download : Download high-res image (173KB)
- Download : Download full-size image
3.
4.
5.
《European journal of medical genetics》2020,63(4):103825
BackgroundThe collagen type IV alpha 1 chain (COL4A1) is an essential component of the basement membrane in small vessels. Pathogenic variants in COL4A1 cause perinatal cerebral hemorrhages in an autosomal-dominant fashion. However, little is known about the long-term outcomes of patients with mildly affecting COL4A1 mutations.Case reportWe report a 17-year-old boy, who presented with recurrent intracranial hemorrhages in the periventricular white matter. He had been followed-up as a child with cerebral palsy bearing intracranial calcifications, developmental delay and epilepsy. Screening tests in infancy provided negative results for intrauterine infections. Severe motor and cognitive deficits persisted after admission. Carbazochrome was introduced on day 19 of admission, which appeared to prevent extension and reactivation of cerebral hemorrhages for over 6 months after discharge.ResultsTargeted sequencing of NOTCH3 and TREX1 excluded causal mutations in these genes. The whole-exome sequencing revealed that he carried a de novo mutation in COL4A1 (p.Gly696Ser). An overview of the literature for 345 cases with COL4A1 mutations supported evidence that p.Gly696Ser is associated with the unique phenotype of late-onset hemorrhage among patients with COL4A1-associated cerebral angiopathy.ConclusionsThis case first demonstrates that infants with COL4A1-associated leukoencephalopathy and calcifications have a risk for developing the rupture of small vessels in the cerebral white matter after 10 years of age. 相似文献
6.
7.
《Drug discovery today》2022,27(6):1733-1742
Compounds that exhibit assay interference or undesirable mechanisms of bioactivity are routinely encountered in assays at various stages of drug discovery. We observed that assays for the investigation of thiol-reactive and redox-active compounds have not been collected in a comprehensive review. Here, we review these assays and subject them to experimental optimization to improve their reliability. We demonstrate the usefulness of our assay cascade by assaying a library of bioactive compounds, chemical probes, and a set of approved drugs. These high-throughput assays should complement the array of wet-lab and in silico assays during the initial stages of hit discovery campaigns to pursue only hit compounds with tractable mechanisms of action. 相似文献
8.
《Asian journal of surgery / Asian Surgical Association》2021,44(8):1037-1042
BackgroundStoma-related obstruction (SRO) is defined as small bowel obstruction occurring around the limbs of diverting ileostomy (DI). This study was aimed to investigate the incidence, risk factors, and management of SRO after laparoscopic colorectal surgery with DI creation.MethodsThis study included 155 patients who underwent laparoscopic colorectal surgery with DI creation for rectal cancer (n = 138), ulcerative colitis (UC) (n = 14), and familial adenomatous polyposis (FAP) (n = 3) between 2011 and 2019. Univariate and multivariate analyses were performed to identify the risk factors of SRO.ResultsThe incidence of SRO was 7.7% (n = 12), and it was significantly lower (P < 0.01) in patients with lower anterior resection or intersphincteric resection (4.3%) than in those with ileal-pouch anal anastomosis (IPAA) (35.2%). The multivariate analysis revealed that IPAA was independently associated with the development of SRO (P = 0.001; odds ratio, 9.4; 95% confidence interval, 2.5–35.4). Eleven of 12 patients (92%) with SRO required trans-stomal tube decompression, and 8 of those (67%) underwent early stoma closure.ConclusionIPAA was an independent risk factor of SRO in laparoscopic colorectal surgery with DI creation. Early stoma closure was needed in most cases of SRO. 相似文献
9.
10.
Jin Wu Hao Wang Qing Li Qian-Ying Guo Si-Qi Tao Yu-Xian Shen Zheng-Sheng Wu 《Pathology, research and practice》2019,215(9):152523
Mammary carcinoma (MC) is one of most common malignancy in women, and ring finger protein 2 (RNF2) possesses various roles in vast human tumors. In MC tissues as well as in cell lines RNF2 exhibited high expression, had significant association with tumor size, lymph node status, TNM stage, patients’ poor survival, and promoted cell proliferation, colony formation, cell migration and invasion of MC cell lines which was mediated by downregulation of E-cadherin protein. These data reveal that RNF2 protein plays a vital role in the development of MC and may be a potential therapy target of MC. 相似文献