全文获取类型
收费全文 | 3624篇 |
免费 | 185篇 |
国内免费 | 32篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 27篇 |
妇产科学 | 7篇 |
基础医学 | 314篇 |
口腔科学 | 1115篇 |
临床医学 | 126篇 |
内科学 | 253篇 |
皮肤病学 | 38篇 |
神经病学 | 92篇 |
特种医学 | 75篇 |
外科学 | 236篇 |
综合类 | 357篇 |
预防医学 | 448篇 |
眼科学 | 12篇 |
药学 | 587篇 |
中国医学 | 82篇 |
肿瘤学 | 61篇 |
出版年
2023年 | 42篇 |
2022年 | 66篇 |
2021年 | 85篇 |
2020年 | 69篇 |
2019年 | 90篇 |
2018年 | 81篇 |
2017年 | 80篇 |
2016年 | 87篇 |
2015年 | 82篇 |
2014年 | 224篇 |
2013年 | 208篇 |
2012年 | 213篇 |
2011年 | 210篇 |
2010年 | 151篇 |
2009年 | 141篇 |
2008年 | 140篇 |
2007年 | 126篇 |
2006年 | 122篇 |
2005年 | 130篇 |
2004年 | 125篇 |
2003年 | 123篇 |
2002年 | 106篇 |
2001年 | 72篇 |
2000年 | 78篇 |
1999年 | 98篇 |
1998年 | 57篇 |
1997年 | 58篇 |
1996年 | 58篇 |
1995年 | 60篇 |
1994年 | 50篇 |
1993年 | 52篇 |
1992年 | 46篇 |
1991年 | 48篇 |
1990年 | 36篇 |
1989年 | 28篇 |
1988年 | 36篇 |
1987年 | 16篇 |
1986年 | 23篇 |
1985年 | 79篇 |
1984年 | 34篇 |
1983年 | 41篇 |
1982年 | 32篇 |
1981年 | 29篇 |
1980年 | 20篇 |
1979年 | 13篇 |
1978年 | 23篇 |
1976年 | 7篇 |
1975年 | 7篇 |
1974年 | 11篇 |
1973年 | 11篇 |
排序方式: 共有3841条查询结果,搜索用时 15 毫秒
1.
IntroductionThis study was designed to assess whether a dental caries management protocol combining a single application of 38% silver diamine fluoride (SDF) with comprehensive oral health education will successfully divert high-risk children from dental treatment under dental general anaesthesia (DGA), arrest active caries in primary teeth, and improve parent-reported child oral health–related quality of life (OHRQoL).MethodsChildren aged 2 to 10 years, who attended two public dental agencies in Victoria, Australia, and were unable to tolerate restorative treatments in the clinic setting, elected to participate in either a 38% SDF intervention protocol or, alternatively, referral for DGA. Follow-up examinations were completed at 6 months to assess caries progression, decayed missing filled tooth index, PUFA index (pulpal involvement, ulceration, fistula, abscess), DGA referral rates, and OHRQoL (Early Childhood Oral Health Impact Scale [ECOHIS]).ResultsOf the total sample, 89.5% of children (n = 102) [mean (SD) age, 4.1 (1.0) years] with 401 active carious lesions elected to participate in the 38% SDF protocol; 10.5% (n = 12) of parents opted for referral for treatment under DGA. The proportion of active caries subsequently arrested at follow-up (number of arrested lesions/number of lesions treated) was 0.78 (95% CI, 0.69 to 0.87). There was an 88% reduction in referrals for DGA in eligible children over the 6-month period. The 38% SDF intervention group showed a significant improvement in ECOHIS scores at follow-up (P < .001).DiscussionAdoption of the 38% SDF intervention protocol resulted in a significant reduction in the rate of preventable dental hospitalisations. Most parents opted against referral for DGA. Parent-reported OHRQoL for children improved significantly. 相似文献
2.
3.
《Biomaterials》2015
Malignant glioma is the most common intracranial tumor with a dismal prognosis. The radiosensitizing effect of silver nanoparticles (AgNPs) on glioma both in vitro and in vivo had been demonstrated in the previous studies of our group. However, the underlying mechanism is still unclear. Consistent with previous studies, a size and dose dependent antitumor effect and significant radiosensitivity enhancing effect of AgNPs were observed in our experiment system. We also found that cell protective autophagy could be induced by AgNPs and/or radiation, which was verified by the use of 3-MA. The mechanism through which had autophagy and the enhancement of radiosensitivity taken place was further investigated with inhibitors of ERK and JNK pathways. We demonstrated that ERK and JNK played pivotal roles in the radiosensitivity enhancement. Inhibiting ERK and JNK with U0126 and SP600125 respectively, we found that the autophagy level of the cells treated with AgNPs and radiation were attenuated. Moreover, SP600125 down-regulated the apoptosis rate of the co-treated cells significantly. Taken together, the present study would have important impact on biomedical applications of AgNPs and clinical treatment for glioma. 相似文献
4.
Kayoko Minakata Masako Suzuki Hideki Nozawa Kunio Gonmori Kanako Watanabe Osamu Suzuki 《Forensic Toxicology》2006,24(2):83-87
Platinum (Pt) levels were determined in various tissues and body fluids obtained from a patient who died 181 days after cisplatin
overdosing. The symptoms of cisplatin overdose, however, might have almost disappeared by day 40, and the patient’s death
was ascribed to the recurrence of malignant lymphoma. Determination of Pt derived from cisplatin was performed by electrospray
ionization mass spectrometry (ESI-MS) using silver (Ag) as internal standard. Pt and Ag complexed with diethyldithiocarbamate
(DDC) in wetashed blood, and tissue solutions were extracted into isoamyl alcohol, and then acidified with oxalic acid. By
injecting an aliquot of the isoamyl alcohol layer into a mass spectrometer in the direct flow injection mode, the quantitation
was performed using the signals of Pt(DDC)3
+ and Ag(DDC)2
+ at m/z 639 and 403, respectively. The Pt levels ranged from 25ng/ml in blood to 2050ng/g wet weight in the liver of the patient,
indicating that Pt remained at high levels in tissues, even after a period as long as 181 days after cisplatin overdosing. 相似文献
5.
腹股沟区淋巴静脉分流加硝酸银肾盂灌注治疗乳糜尿的临床疗效 总被引:1,自引:0,他引:1
目的 探讨腹股沟区淋巴静脉分流加硝酸银肾盂灌注治疗乳糜尿的疗效。方法 采用2%硝酸银肾盂灌注加同侧腹股沟区淋巴结与大隐静脉主干吻合方法治疗乳糜尿患者28例。其中男16例,女12例,年龄41~68岁,平均46岁。病史6个月~30年,平均3.6年。乳糜尿来自左肾14例,右肾12例,双肾2例。结果 术后3d内尿乳糜试验转阴者8例,7d转阴者17例,11d转阴者3例。27例随访3~12年,复发3例,复发率11%。结论 腹股沟区淋巴静脉分流加硝酸银肾盂灌注是治疗乳糜尿简单、安全、有效的方法,适宜于基层医院开展。 相似文献
6.
DTF降茶氟剂降茶氟初步研究 总被引:9,自引:1,他引:8
王连方 《中国地方病防治杂志》2003,18(1):17-19
目的探讨DTF制剂降茶氟效果。方法在不同制茶方法程序中加入DTF制剂观察其降氟效果。结果在冲泡或煮沸(1.0g茶叶,200ml水量)沏茶中,0.2gDTF可使茶氟降低约60%,使茶水氟浓度由2.0~4.0mg/L降到1.0mg/L左右,茶液色、味、pH值无改变。结论DTF是1种有效的降茶氟剂。 相似文献
7.
过量氟化物导致大鼠腰椎黄韧带退变与骨化 总被引:2,自引:0,他引:2
[目的]研究氟化物在黄韧带骨化中可能的作用机理。[方法]36只雄性SD大鼠,实验组饮用含NaF(质量分数为1014)蒸馏水,分别于3个月及6个月时,检测骨密度,血清、骨组织标本中Ca、P^3+、Mg、Zn、Cu、Fe、F^-含量和血清碱性磷酸酶(ALP)活性;行大鼠腰段标本X线检查后组织病理观察。[结果]3个月实验组10只大鼠中6只出现氟斑牙:6个月实验组均出现氟斑牙,且大鼠中轴骨骨密度显著增加(P〈0.05)。X线检查,6个月实验组中有4只可见黄韧带嵴状骨化影。病理观察,3个月实验组大鼠黄韧带呈退行性改变;6个月实验组部分黄韧带骨化,骨化类型以膜内骨化为主。[结论]过量氟化物可造成SD大鼠腰椎黄韧带的退变、骨化,在黄韧带的骨化中可能起重要作用。 相似文献
8.
目的:明确氟对人牙乳头细胞合成 I型胶原的影响。 方法:对人牙乳头细胞进行体外培养 ,分别给予0 .0、0 .2× 10 - 6、1.0× 10 - 6、5 .0× 10 - 6、2 5 .0× 10 - 6 g/ L 氟处理 ,采用免疫细胞化学方法染色 ,图象分析氟对细胞合成 I型胶原的影响。 结果:I型胶原在对照组和 4种氟浓度处理组细胞表达均为阳性。图象分析结果表明 ,4种氟浓度对体外培养的人牙乳头细胞合成 I型胶原量与对照组相比差异无统计学意义 (P>0 .0 5 )。结论:过量氟对牙本质基质 型胶原的影响可能不是通过影响成牙本质细胞内合成实现的 相似文献
9.
10.
对114例不同类型和级别的结肠癌进行银染核仁形成区嗜银蛋白(Ag-NORs)形态定量研究.结果表明,Ag-NORs数量、大小和分布在结肠未分化癌和印戒细胞癌组与管状腺癌和粘液腺癌组比较,有明显差异.管状腺癌随分化程度的降低,Ag-NORs的数量、形态、大小和分布也发生等级性变化.结果提示,Ag-NORs形态定量的数量、形态、大小和分布4项指标对结肠癌分型有一定意义,对管状腺癌分级有较好的诊断价值。 相似文献