Histological and histomorphometrical changes in rat alveolar bone following antagonistic tooth extraction and/or ovariectomy

OBJECTIVE: To examine changes appearing in the alveolar bone following the removal of the mechanical stress of occlusal loading, as well as the added influence of estrogen deficiency on such changes. DESIGN: The right mandibular molars of female rats were extracted. After 8 weeks, 12 animals were ovariectomized (OVX), and the other 12 were subjected to sham surgery (sham). Four weeks after surgery, all rats were sacrificed. The left-half and right-half maxillas of the sham group (the sham-occluded side and the sham-extruded side, respectively) and right-half maxilla of OVX group (the OVX-extruded side) were examined by histological observation and bone histomorphometry. RESULTS: The vertical height of alveolar bone in the sham-extruded and the OVX-extruded sides increased as compared with that of the sham-occluded side. In both extruded sides, active bone formation occurred on the surface of the alveolar bone facing the periodontal ligament, but the bone marrow was expanded and the bone volume had decreased in the internal area of the alveolar bone. In the OVX-extruded side, the bone marrow expanded more remarkably than that of the sham-extruded side, and the highest percentage of osteoclast surface was detected. CONCLUSIONS: Around the extruded teeth, there were regional differences in bone dynamics between the internal area of the alveolar bone and the bone surface facing the periodontal ligament, and estrogen deficiency seems to have caused further loss of bone volume in the interior of the alveolar bone supporting the extruded tooth.     

腺垂体功能减退症123例临床分析

目的 提高对腺垂体功能减退症的认识。方法 对安徽医科大学第二附属医院内分泌科2015年8月至2020年9月收治的123例腺垂体功能减退症病人的资料进行回顾性分析。结果 男47例（38.2%）,女76例（61.8%）,年龄范围16～83岁。颅内占位或术后49例（39.9%）,希恩综合征39例（31.7%）,空泡蝶鞍综合征15例（12.2%）,下丘脑-垂体发育不良9例（7.3%）,病因不明11例（8.9%）。以消化道症状就诊47例（38.2%,为首要就诊症状）,垂体危象23例（18.7%）。性腺轴受损104例（86.7%,为最主要受损腺体）,3个腺体（性腺轴、甲状腺轴、肾上腺轴）均受损61例（55.5%）。低钠血症60例（52.2%）,血脂异常87例（75%）,低血糖21例（18.8%）,贫血47例（40.9%）。结论 腺垂体功能减退症临床表现多样,应提高对该病的认识,避免误诊和漏诊,确诊后及时予以激素替代治疗。     

Influence of Occlusal Stimuli on the Microvasculature in Rat Dental Pulp

Objective:To examine the influence of occlusal stimuli on the vasculature in the dental pulp, using an occlusal hypofunction model.Materials and Methods:Twenty 7-week-old male Sprague-Dawley rats were divided into two groups. To produce occlusal hypofunction, the appliances were attached to the maxillary and mandibular incisors. Untreated rats served as controls. Serial horizontal paraffin sections of the mandibular first molar were processed by conventional methods. To evaluate the microvasculature in the dental pulp, sections of each specimen were stained with hematoxylin-eosin.Results:In the experimental group, the arterioles in the tooth pulp tissue ran convergently, and their inside diameter was significantly smaller than that of the control group.Conclusion:This study suggests that occlusal stimuli influence the periodontal ligament throughout the microvasculature of the dental pulp.     

胃癌癌前病变与脾虚胃热气滞血瘀的关系

对１１７例经胃粘膜活检病理检查确诊为胃粘膜上皮不典型增生、不完全性结肠型肠上皮化生患者的发病诱因进行了调查，结果显示发病诱因以饥饱失调、忧思恼怒及烟酒过度为主，长期饥饱失宜而致脾胃气虚之证，日久气机不畅致化热成瘀。脾虚胃热、气滞血瘀之间可相互影响、相互转化而形成虚实挟杂之证。在治疗上应针对病机采用健脾清热、行气活血、化瘀散结之大法，选用相应的药物而治之。     

鼠牙正畸移动中牙周膜功能状态与牙根吸收的关系

目的:探讨鼠牙正畸移动中牙周膜功能状态与牙根吸收的关系。方法:选择33只6~8周龄体质量(250±20)g的SD大鼠,随机分为正常对照组(C组,11只)和实验组(22只)。通过拔除实验组大鼠右下颌所有磨牙,使上颌左、右第一磨牙咬合力改变,3周后分别形成牙周膜代偿性机能亢进模型和牙周膜废用性萎缩模型,据此实验组又分为萎缩组与亢进组(A、B组,各11只)。在各组大鼠上颌切牙和第一磨牙间放置5mm镍钛螺簧,初始力值0.59N(60g),近中移动磨牙。14d后处死动物,拍摄X线片测定各组牙齿移动距离,并通过抗酒石酸酸性磷酸酶染色测定牙根吸收情况。结果:牙周膜废用性萎缩组牙根吸收程度〔(44.064±13.531)μm〕明显大于B、C2组〔(20.648±2.491μm),(28.045±5.683)μm,P<0.01〕,且牙移动距离B组与A、C2组也有显著性差异(P<0.01)。结论:正畸牙移动中,牙周膜废用性萎缩的无咬合接触牙较咬合力代偿性增强或正常咬合接触牙更易发生牙根吸收。     

炉甘散对豚鼠口腔溃疡模型的影响

炉甘散对豚鼠口腔溃疡模型的影响路绪文，王书杰（中国人民解放军第２５１医院张家口０７５０００）炉甘散为我院研制的以炉甘石、甘草、冰片为主要成分的纯中药制剂，为证实其对口腔溃疡的治疗作用，本文采用稀盐酸化学烧伤型豚鼠口腔溃疡模型，对炉甘散治疗口腔溃疡进行...     

血脂康胶囊治疗高脂血症临床观察

对４４６例高脂血症又属中医脾虚、痰瘀阻滞症的患者，进行随机分组。一为血脂康胶囊（由红曲制成，下称血脂康）治疗组３Ｈ例，一为阳性药组（下称对照组）１２２例。８周为１疗程。观察结果，血脂康总显效率为７９．７％（２５８／３Ｈ），对照组为３１．２％（３８／１２２）。血脂康组总胆固醇（ＴＣ）、甘油三酯（ＴＧ）下降率分别是２３．０％、３６．５％，下降明显（Ｐ＜０．００１）；高密度脂蛋白胆固醇（ＨＤＬ一Ｃ）上升１９．６％，升高明显（Ｐ＜０．００１）。对照组这些指标比疗前也明显下降（Ｐ＜０．００１）。二组相比，总显效率及各项指标的改善，血脂康均优于对照组（Ｐ＜０．００１）。综合分析，血脂康是安全有效的。     

鼠正畸牙移动中废用性萎缩牙周膜与牙槽骨改建关系的研究

目的:探讨大鼠磨牙牙周膜废用性萎缩功能状态对正畸牙槽骨改建的影响。方法:选择30只5周龄体重(250g±20g)的SD大鼠,随机分为牙周膜废用性萎缩组(15只)和正常对照组(15只)。通过拔除实验组大鼠右下颌所有磨牙使右上颌第一磨牙丧失咬合接触,3周后形成牙周膜废用性萎缩动物模型。在两组大鼠上颌切牙和第一磨牙间放置5mm镍钛螺簧,初始力值50g,近中移动磨牙。分别于加力后0、3、7、14d处死动物,通过组织学方法对第一磨牙压力侧牙槽骨破骨细胞进行染色并记数;并对14d组拍摄X光片测定牙齿移动距离。结果:牙周膜废用性萎缩组牙齿移动距离(0.611mm±0.142mm)小于正常对照组(0.679mm±.090mm),差异无显著性(P>0.05);萎缩组大鼠压力侧破骨细胞数在实验全过程中(除0d外)均低于对照组,差异有显著性。结论:正畸治疗中,无咬合接触的牙周膜废用性萎缩牙较正常咬合接触牙对矫治力反应差,骨改建率低,易发生玻璃样变和潜掘性骨吸收,延缓牙移动,因此对无咬合接触牙的临床治疗中应采用轻力。     

四君子汤对脾虚证模型大鼠淋巴细胞功能的影响

为探讨四君子汤对机体免疫功能的影响。采用利血平注射法复制脾虚证模型。以分别代表细胞与体液免疫功能的T、B淋巴细胞活性及血清IgG、IgM的水平为指针,观察了益气健脾基本方剂四君子汤对它们的影响。结果发现脾虚证模型大鼠较正常大鼠T淋巴细胞转化率及血清IgM水平显著降低。四群子汤防治组与正常大鼠无显著差异。提示四君子汤对脾虚证的防治作用表现为增强T淋巴细胞活性及升高IgM水平的作用两上方面。