人乳头瘤病毒及其相关皮肤病

人乳头瘤病毒是一种双链闭环DNA病毒,目前已分离鉴定出118型。根据作用靶点,分为皮肤型和黏膜型,其中皮肤型包括疣状表皮发育不良相关的狭义人乳头瘤病毒型,根据致癌程度不同分为高危型、中危型和低危型。在人乳头瘤病毒相关的皮肤病中,除了常见疣外,还与鲍恩病、疣状表皮发育不良、尖锐湿疣、鲍恩样丘疹病、银屑病等有密切联系,值得进一步研究。     

Dermoscopic evaluation of vascular structures of various skin tumors in Japanese patients

Dermoscopic analysis of skin tumor has been mainly focused on pigmented structures. Recently, several different morphological types of vessels were found to be well associated with pigmented or non‐pigmented skin tumors in white subjects. Therefore, the recognition of such vascular structures has been applied for diagnostic purposes. As little statistical information on the various pigmented skin tumor vessels of Japanese patients has been reported, we therefore tried to evaluate the association between various vascular structures and 741 tumor lesions of Japanese patients. Vascular structures were dermoscopically recognized in 41 of 102 cases of melanoma, 104 of 119 basal cell carcinoma (BCC), 86 of 257 seborrheic keratosis (SK), 35 of 210 dermal and compound nevus (DN/CN), six of 12 squamous cell carcinoma (SCC) and 16 of 41 Bowen disease (BD). The structures of arborizing and glomerular vessels statistically revealed diagnostic specificity for BCC and BD, respectively, and hairpin vessels were helpful for differentiating SK from other pigmented tumors, as already reported in white patients. The most common vascular pattern observed in melanoma was the linear–irregular structure, but this pattern in Japanese patients had less diagnostic value than in white patients, because its sensitivity was not significantly higher than in SCC. The most remarkable differences between our study and previous reports with white patients were low frequency and sensitivity of dotted, comma and polymorphous vessels in lesions of melanoma, BCC and DN/CN; these vessels had less diagnostic value for Japanese patients. Finally, the frequency of vascular structures observed in melanoma rose along with the increase of the Breslow’s tumor thickness, and 88% of melanomas with vascular vessels revealed tumor thicknesses of more than 2 mm.     

CD200在皮肤鳞癌进展过程中的表达

目的研究CD200蛋白在皮肤鳞癌不同进展阶段中的变化趋势。方法收集正常皮肤、日光性角化病、鲍温病、鳞癌、浸润鳞癌的皮肤组织标本各20例,免疫组织化学法检测CD200蛋白在组织中的表达。结果日光性角化、鲍温病、鳞癌和浸润鳞癌组织CD200的表达比例均较正常组织显著增高（P〈0.01）;鳞癌和浸润鳞癌组织CD200的表达比例较日光性角化及鲍温病均显著增高（P〈0.01）。结论 CD200的高表达可能促进了皮肤鳞癌的进展。     

女阴鲍温样丘疹病的诊断(附五例报告)

报告５例鲍温样丘疹病的临床表现及病理特征。该病为良性病变，可自行消退。主要讨论其与Ｂｏｗｅｎ病及Ｐａｇｅｔ病的鉴别诊断，强调正确诊断须临床与病理标准相结合。建议采取保守治疗并进行随访。     

T. AUBREY BOWEN,OCULIST, 1837–93. HIS CHARITABLE BEQUESTS IN VICTORIA

During the economic depression which engulfed Victoria in the 1890s, T. Aubrey Bowen bequeathed 20,000 for division amongst Victorian charitable and benevolent institutions. Five buildings resulting from this bequest were: the Aubrey Bowen Wing at The Victorian Eye and Ear Hospital, the Bowen Memorial Operating Theatre at the Melbourne Hospital, the Bowen Block at the Austin Hospital, the Aubrey Bowen Operating Room and Wards at the Geelong Infirmary and Benevolent Asylum, and the Aubrey Bowen Cottage at the Old Colonists’Homes.     

5-氨基酮戊酸光动力疗法（ALA-PDT）治疗老年面部Bowen病的疗效观察

目的：观察5-氨基酮戊酸光动力疗法（ALA-PDT）治疗老年面部Bowen病的疗效和美容效果。方法：对10例年龄大于65岁、患高血压、糖尿病或不愿手术治疗的Bowen病患者面部皮损进行ALA-PDT治疗。结果：10例Bowen病患者的18个皮损获得完全缓解,1例复发,复发率10%。结论：对老年面部Bowen病,ALA-PDT是一种痛苦小、疗效好、无瘢痕形成、复发率低、美容效果好的治疗方法。     

Tratamiento de la enfermedad de Bowen con imiquimod 5% crema

Imiquimod is an immune modifier that has been shown to be effective for some skin cancer and precancer such as solar keratoses, basal cell carcinoma and Bowen's disease. It has been proved to have antiviral and antitumor properties in animal models. The biological pathway is closely related with the release of some cytokines, mainly interferon (INF)-α and tumoral necrosis factor (TNF)-α.A trial with imiquimod 5% cream, twice daily, three times a week, during 8 weeks was undertaken in 5 patients with biopsy-proven Bowen's disease. One patient had undergone a renal transplantation and was on chronic immunosupressive chemotherapy for 8 years. Lesions were located on the legs, hands and face. After treatment all lesions had cleared up, and in three patients clearance was histologically confirmed with a posttreatment biopsy. All patients complained of mild erythema and itching, but the treatment was well tolerated. Within follow-up periods of 3 to 11 months after treatment none has shown evidence of recurrence.Even though this is a short series of patients, we believe that imiquimod 5% cream is an effective and safe treatment for Bowen's disease at a shorter term than previously advised. Since Bowen's lesions were not fully excised at the end of the treatment, only a longer follow up of our patients will confirm their clearance.