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H.J. ten Donkelaar R. de Boer-van Huizen F.T.M. Schouten S.J.H. Eggen 《Neuroscience》1981,6(11):2297-2312
The cells of origin of pathways descending to the spinal cord in the clawed toad Xenopus laevis have been demonstrated with the horseradish peroxidase technique. A technique has been used taking advantage of the phenomenon that damaged axons can take up horseradish peroxidase and transport this enzyme to their parent cell bodies. The following descending supraspinal pathways could be demonstrated: a striatospinal pathway to the rostral part of the cord; distinct hypothalamospinal projections; a projection as far as the lumbar cord from the ventral thalamic nucleus; distinct projections from the mesencephalic tegmentum; a contralateral cerebellospinal projection from the cerebellar nucleus; a projection from neurons directly medial to the nucleus isthmi which shows resemblance to the coeruleospinal pathway of higher veretebrates; massive reticulospinal projections; a vestibulospinal projection arising in the nucleus ventralis VIII and pathways arising in nuclei receiving lateral line afferents. Furthermore, spinal projections from the nucleus of the solitary tract and the nucleus descendons nervi trigemini were observed.Rather massive projections were found to arise in the midbrain tegmentum: a mainly ipsilateral projection from the interstitial nucleus of the fasciculus longitudinalis medialis, a contralateral projection as far as the lumbar cord from a cell group which presumably represents the anuran homologue of the red nucleus of higher vertebrates, and projections from various other parts of the midbrain tegmentum, mainly to more rostral levels of the cord. Only a very small tectospinal projection could be demonstrated.A comparison with experimental data in higher vertebrates makes it likely that the pathways demonstrated from the hypothalamus and brain stem in Xenopus laevis show remarkable similarities to pathways in reptiles, birds and mammals. 相似文献
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The distribution of serotonin-containing nerve cell bodies, fibers and terminals in the lizard Varanus exanthematicus was studied with the indirect immunofluorescence technique, using antibodies to serotonin. Most of the serotonin-containing cell bodies were found in the midline, in both of the raphe nuclei, i.e. the nuclei raphes superior and inferior. A considerable number of more laterally shifted serotonergic neurons was found particularly at three levels of the brain stem, viz. in the caudal mesencephalic tegmentum, at the isthmic level, and over a long distance in the medulla oblongata. These laterally situated serotonin-positive neurons were partly found within the confines of the substantia nigra, the nucleus reticularis superior and the lateral part of the nucleus reticularis medius and ventrolateral part of the nucleus reticularis inferior, respectively. No serotonergic cell bodies were found in the spinal cord. In the brain stem a dense serotonergic innervation was observed in all of the motor nuclei of the cranial nerves, in two layers of the tectum mesencephali, in the nucleus interpeduncularis pars ventralis, the nucleus profundus mesencephali pars rostralis, the periventricular grey, the nucleus parabrachialis, the vestibular nuclear complex, the nucleus descendens nervi trigemini, the nucleus raphes inferior, and parts of the nucleus tractus solitarii. Descending serotonergic pathways could be traced into the spinal cord via the dorsolateral, ventral and ventromedial funiculi, and were found to innervate mainly three parts of the spinal grey throughout the spinal cord, i.e. the dorsal part of the dorsal horn, the motoneuron area in the ventral horn, and the intermediate zone just lateral to the central canal. The results obtained in the present study suggest a close resemblance of the organization of the serotonergic system in reptiles and mammals, especially as to the serotonergic innervation of the spinal cord. 相似文献
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