全文获取类型
收费全文 | 6950篇 |
免费 | 603篇 |
国内免费 | 112篇 |
专业分类
耳鼻咽喉 | 105篇 |
儿科学 | 1101篇 |
妇产科学 | 226篇 |
基础医学 | 1575篇 |
口腔科学 | 432篇 |
临床医学 | 344篇 |
内科学 | 1023篇 |
皮肤病学 | 113篇 |
神经病学 | 469篇 |
特种医学 | 317篇 |
外科学 | 964篇 |
综合类 | 369篇 |
现状与发展 | 2篇 |
预防医学 | 141篇 |
眼科学 | 79篇 |
药学 | 114篇 |
2篇 | |
中国医学 | 31篇 |
肿瘤学 | 258篇 |
出版年
2024年 | 15篇 |
2023年 | 132篇 |
2022年 | 253篇 |
2021年 | 284篇 |
2020年 | 271篇 |
2019年 | 322篇 |
2018年 | 260篇 |
2017年 | 257篇 |
2016年 | 267篇 |
2015年 | 230篇 |
2014年 | 448篇 |
2013年 | 408篇 |
2012年 | 253篇 |
2011年 | 351篇 |
2010年 | 291篇 |
2009年 | 300篇 |
2008年 | 279篇 |
2007年 | 279篇 |
2006年 | 234篇 |
2005年 | 224篇 |
2004年 | 184篇 |
2003年 | 163篇 |
2002年 | 149篇 |
2001年 | 144篇 |
2000年 | 138篇 |
1999年 | 122篇 |
1998年 | 152篇 |
1997年 | 122篇 |
1996年 | 128篇 |
1995年 | 93篇 |
1994年 | 74篇 |
1993年 | 101篇 |
1992年 | 93篇 |
1991年 | 76篇 |
1990年 | 43篇 |
1989年 | 46篇 |
1988年 | 44篇 |
1987年 | 44篇 |
1986年 | 41篇 |
1985年 | 55篇 |
1984年 | 45篇 |
1983年 | 36篇 |
1982年 | 34篇 |
1981年 | 42篇 |
1980年 | 41篇 |
1979年 | 25篇 |
1978年 | 24篇 |
1977年 | 20篇 |
1976年 | 10篇 |
1973年 | 6篇 |
排序方式: 共有7665条查询结果,搜索用时 15 毫秒
1.
《European journal of medical genetics》2022,65(6):104495
Spondyloepimetaphyseal dysplasias (SEMDs) belong to a clinically and genetically heterogeneous group of inherited skeletal disorders defined by a defect in the growth and shape of vertebrae, epiphyses and metaphyses. Rhizomelic SEMD is characterized by a disproportionate small stature caused by severe shortening and deformation of the limbs’ proximal bones, with the cranio-facial sphere unaffected. We report a second individual, an 8-year-old girl, with autosomal recessive rhizomelic SEMD associated with a homozygous exonic missense variant, c.226G > A p.(Glu76Lys), in GNPNAT1 identified by trio genome sequencing. Our data corroborate the recent findings of Ain et al. and further delineate the clinical and radiographic features of this form of SEMD associated with rhizomelic dysplasia while outlining a potential hotspot in this newly described genetic disorder. 相似文献
2.
3.
《Journal of vascular and interventional radiology : JVIR》2022,33(4):399-407
PurposeTo evaluate the midterm outcomes of percutaneous transluminal renal angioplasty (PTRA) for pediatric renovascular hypertension (RVH).Materials and MethodsThe clinical data of patients who underwent PTRA for RVH in the authors’ hospital from 2012 to 2019 were retrospectively analyzed. Postprocedural blood pressure, glomerular filtration rate (GFR) of the affected kidney, restenosis, and complications were closely monitored.ResultsPTRA was performed in a total of 30 children (20 boys and 10 girls), with a mean age of 7.3 years ± 0.7 (range, 40 days to 13.9 years) and a mean weight of 25.0 kg ± 2.3 (range, 3.4–53 kg). The median follow-up period was 26.5 months (range, 1 month to 7.5 years). Technical success was achieved in 26 (86.7%) of the 30 patients. Restenosis developed in 3 patients (10.0%). Only 1 patient underwent stent implantation, and the stent fractured 8 months later, requiring further intervention. There were no other complications. In terms of clinical benefit of blood pressure control after the initial PTRA procedure, 15 patients (50%) were cured and 7 patients (23.3%) showed improvement. There was no significant difference in the etiology, lesion location, and lesion length between patients with clinical benefit and failure (P = .06, P = .202, and P = .06, respectively). GFR of the affected kidney was significantly improved from 19.9 mL/min ± 11.2 to 38.1 mL/min ± 11.9 at the 6-month follow-up after PTRA (P < .001).ConclusionsThe overall results of PTRA for pediatric RVH caused by different etiologies are promising. PTRA not only provided a clinical benefit of blood pressure control in 73.3% of the patients but also significantly improved the function of the affected kidney. 相似文献
4.
5.
《Clinical neurophysiology》2019,130(1):128-137
ObjectiveHigh frequency oscillations (HFO) between 80–500 Hz are markers of epileptic areas in intracranial and maybe also scalp EEG. We investigate simultaneous recordings of scalp and intracranial EEG and hypothesize that scalp HFOs provide important additional clinical information in the presurgical setting.MethodsSpikes and HFOs were visually identified in all intracranial scalp EEG channels. Analysis of correlation of event location between intracranial and scalp EEG as well as relationship between events and the SOZ and zone of surgical removal was performed.Results24 patients could be included, 23 showed spikes and 19 HFOs on scalp recordings. In 15/19 patients highest scalp HFO rate was located over the implantation side, with 13 patients having the highest scalp and intracranial HFO rate over the same region. 17 patients underwent surgery, 7 became seizure free. Patients with poor post-operative outcome showed significantly more regions with HFO than those with seizure free outcome.ConclusionsScalp HFOs are mostly located over the SOZ. Widespread scalp HFOs are indicative of a larger epileptic network and associated with poor postsurgical outcome.SignificanceAnalysis of scalp HFO add clinically important information about the extent of epileptic areas during presurgical simultaneous scalp and intracranial EEG recordings. 相似文献
6.
7.
Takashi Murakami Naoto Sakamoto Akihito Nagahara 《Journal of gastroenterology and hepatology》2019,34(10):1685-1695
Sessile serrated adenoma/polyps (SSA/Ps) are early precursor lesions in the serrated neoplasia pathway, which results in BRAF‐mutated colorectal carcinomas with not only high levels of microsatellite instability but also microsatellite stable. SSA/Ps with advanced histology, including cytological dysplasia or minimally invasive carcinomas, are important lesions because SSA/Ps are considered major contributors to “interval cancers” and these lesions can rapidly become dysplastic or invasive carcinomas. Clinicopathologically, SSA/Ps with dysplasia or invasive carcinoma were associated with advanced age, female sex, and proximal colon. Although SSA/Ps with submucosal invasive carcinoma were smaller and invaded less deeply into the submucosal layer than conventional tubular adenomas with submucosal invasive carcinoma, SSA/Ps with submucosal invasive carcinoma frequently had a mucinous component and exhibited a higher potential for lymphatic invasion and lymph node metastasis. In an SSA/P series, endoscopic characteristics, including (semi)pedunculated morphology, double elevation, central depression, and reddishness, may help accurately diagnose SSA/Ps with advanced histology. Removal of SSA/Ps with dysplasia or invasive carcinoma was recommended. Endoscopic treatment such as endoscopic mucosal resection or endoscopic submucosal dissection is useful for those lesions. However, surgical resection with lymph node dissection might be indicated when SSA/Ps with invasive carcinoma are endoscopically suspected, because these have the high risk of lymph node metastasis. Greater awareness may promote further research into improving the detection, recognition, and complete resection rates of SSA/Ps with dysplasia or invasive carcinoma and reduce the interval cancer rates. 相似文献
8.
Over the last 15 years photodynamic therapy (PDT) has become a viable treatment for pre-malignant and malignant disease of the oesophagus. Its initial use was in the palliation of oesophageal malignant obstruction bringing improved swallowing hence increasing nutritional intake and improving general quality of life. As the therapeutic boundaries of PDT have stretched, current studies look at the role of PDT in the treatment of pre-malignant dysplastic Barrett's epithelium and early malignancy as a curative mucosal ablative technique. As a curative treatment in early oesophageal cancer, PDT provides an alternative treatment to oesophagectomy for those more elderly or less medically fit patients.This paper reviews the uses of photodynamic therapy in oesophageal cancer with reference to the available publications on its use in the palliation of oesophageal cancer and treatment of early cancer and high grade dysplasia in Barrett's mucosa. 相似文献
9.
10.
目的探讨股骨近端纤维结构不良的手术治疗方式。方法对19例股骨近端纤维结构不良的不同手术治疗方式及术后疗效进行回顾性分析。结果1例术后3d引流管口渗出血清样物质,加强抗感染、营养支持及换药处理后愈合。19例均获随访,时间13—58个月。复查X线片见缺损修复区内有新骨生成改变,骨折处骨愈合;1例术后20个月因外伤致股骨转子下内固定物旁骨折再次手术发现肿瘤复发,行再次刮除植骨内固定术后14个月愈合;除1例未行内固定的病例外,余患者术后患肢功能均得到良好恢复,8—12个月可弃拐行走。结论股骨近端纤维结构不良应积极手术治疗,在彻底刮除病变和充分植骨的基础上,强调内固定的应用。 相似文献