全文获取类型
收费全文 | 826篇 |
免费 | 67篇 |
国内免费 | 71篇 |
专业分类
儿科学 | 33篇 |
妇产科学 | 5篇 |
基础医学 | 45篇 |
口腔科学 | 7篇 |
临床医学 | 44篇 |
内科学 | 44篇 |
皮肤病学 | 4篇 |
神经病学 | 4篇 |
特种医学 | 12篇 |
外国民族医学 | 1篇 |
外科学 | 42篇 |
综合类 | 273篇 |
预防医学 | 9篇 |
眼科学 | 3篇 |
药学 | 204篇 |
中国医学 | 108篇 |
肿瘤学 | 126篇 |
出版年
2024年 | 2篇 |
2023年 | 5篇 |
2022年 | 7篇 |
2021年 | 13篇 |
2020年 | 6篇 |
2019年 | 14篇 |
2018年 | 16篇 |
2017年 | 15篇 |
2016年 | 13篇 |
2015年 | 18篇 |
2014年 | 40篇 |
2013年 | 41篇 |
2012年 | 42篇 |
2011年 | 57篇 |
2010年 | 37篇 |
2009年 | 43篇 |
2008年 | 35篇 |
2007年 | 49篇 |
2006年 | 46篇 |
2005年 | 50篇 |
2004年 | 52篇 |
2003年 | 20篇 |
2002年 | 30篇 |
2001年 | 36篇 |
2000年 | 30篇 |
1999年 | 24篇 |
1998年 | 21篇 |
1997年 | 18篇 |
1996年 | 23篇 |
1995年 | 15篇 |
1994年 | 19篇 |
1993年 | 14篇 |
1992年 | 9篇 |
1991年 | 6篇 |
1990年 | 10篇 |
1989年 | 9篇 |
1988年 | 9篇 |
1987年 | 5篇 |
1986年 | 4篇 |
1985年 | 9篇 |
1984年 | 6篇 |
1983年 | 8篇 |
1982年 | 5篇 |
1981年 | 9篇 |
1980年 | 5篇 |
1979年 | 4篇 |
1978年 | 7篇 |
1977年 | 3篇 |
1976年 | 4篇 |
1975年 | 1篇 |
排序方式: 共有964条查询结果,搜索用时 15 毫秒
1.
Sarabjit S. Neelam Alvise Bernabei Curtis Freedland Roxanna Thompson Thomas H. Corbett Gordon D. Luk 《Investigational new drugs》1990,8(3):263-268
Summary Unresectable solid tumors in the metastatic stage are quite resistant to current chemotherapy and radiation therapy regimens. Flavone acetic acid (FAA) is a novel antitumor agent which appears to work through a different mechanism than the conventional chemotherapeutic agents. In preclinical studies it has shown effectiveness against a variety of transplantable murine and human tumors and appears to be solid tumor selective. It also has non-overlapping toxicities as compared to conventional agents. We therefore investigated FAA in vitro against human colon cancer cells and explored whether its effectiveness could be enhanced in combination with other agents such as adriamycin (ADR), cis-platinum (CP) and difluoromethyornithine (DFMO) — an inhibitor of polyamine biosynthesis. Addition of FAA for 24 hours in liquid media produced dose dependent growth inhibition. Using soft agar colony assay, growth was inhibited by 58% by 3mM FAA and only 1.4% by 0.375mM FAA. The combination of FAA and cis-platinum produced synergism at the lower doses tested. The combination of FAA and adriamycin produced antagonism at all doses tested and the combination of FAA with DFMO did not produce results significantly different from DFMO alone. We conclude that enhancement of FAA activity can be achieved in combination with conventional antitumor agents, but may be drug and dose specific. 相似文献
2.
Tomáš Šimůnek Martin Štěrba Olga Popelová Michaela Adamcová Radomír Hrdina Vladimír Geršl 《Pharmacological reports : PR》2009,61(1):154-171
The risk of cardiotoxicity is the most serious drawback to the clinical usefulness of anthracycline antineoplastic antibiotics, which include doxorubicin (adriamycin), daunorubicin or epirubicin. Nevertheless, these compounds remain among the most widely used anticancer drugs. The molecular pathogenesis of anthracycline cardiotoxicity remains highly controversial, although the oxidative stress-based hypothesis involving intramyocardial production of reactive oxygen species (ROS) has gained the widest acceptance. Anthracyclines may promote the formation of ROS through redox cycling of their aglycones as well as their anthracycline-iron complexes. This proposed mechanism has become particularly popular in light of the high cardioprotective efficacy of dexrazoxane (ICRF-187). The mechanism of action of this drug has been attributed to its hydrolytic transformation into the iron-chelating metabolite ADR-925, which may act by displacing iron from anthracycline-iron complexes or by chelating free or loosely bound cellular iron, thus preventing site-specific iron-catalyzed ROS damage. However, during the last decade, calls for the critical reassessment of this “ROS and iron” hypothesis have emerged. Numerous antioxidants, although efficient in cellular or acute animal experiments, have failed to alleviate anthracycline cardiotoxicity in clinically relevant chronic animal models or clinical trials. In addition, studies with chelators that are stronger and more selective for iron than ADR-925 have also yielded negative or, at best, mixed outcomes. Hence, several lines of evidence suggest that mechanisms other than the traditionally emphasized “ROS and iron” hypothesis are involved in anthracycline-induced cardiotoxicity and that these alternative mechanisms may be better bases for designing approaches to achieve efficient and safe cardioprotection. 相似文献
3.
阿霉素不同剂量静脉注射的药动学及其临床意义 总被引:1,自引:0,他引:1
采用HPLC法测定14例肿瘤患者使用不同剂量阿霉素的血药浓度,并计算药代参数。40mg/m2和25mg/m2两组的血药峰浓度、AUC、Vc差异有显著性。阿霉素的药代动力学存在明显的个体差异,血药峰浓度、Vc、K12与疗效相关。 相似文献
4.
Agustin Avils Bibiana Soto Renaldo Guzmn Edna L. García M. Jesús Nambo Jos C. Díaz-Maqueo 《Pediatric blood & cancer》1995,24(3):171-175
From January 1986 to December 1989, 157 previously untreated patients, with Hodgkin's disease stage I or II without bulky disease, were enrolled in a clinical comparative study. The objectives of the study were to compare the efficacy and safety of using epirubicine or mitoxantrone instead of adriamycin in the combination chemotherapy regimen ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine). The complete response rate was better in the patients treated with the ABVD or EBVD regimens compared to the MBVD arm. Also, differences in overall survival and relapse-free survival were better in the patients who received ABVD or EBVD compared to the MBVD regimen. Hematological, gastrointestinal and cardiac toxicity were similar in the three groups. Dose intensity, delays and complications were also similar in the three groups. The mitoxantrone-containing regimen was found to have less efficacy in comparison to the other regimens tested in the present study in patients with favorable stage I or II Hodgkin's disease. © 1995 Wi1ey-Liss Inc. 相似文献
5.
Kimura K Nakano T Park YB Tani M Tsuda H Beppu Y Moriya H Yokota J 《Clinical & experimental metastasis》2002,19(6):477-486
Relevant animal models for metastasis of osteosarcoma is needed to understand the biology and to develop the treatment modality
of metastasis of human osteosarcoma. Therefore, we screened six human osteosarcoma cell lines for metastatic ability in nude
mice. The HuO9 cell line was identified as being metastatic to the lung after intravenous injection. We established two sublines,
HuO9-M112 and HuO9-M132, with high metastatic potential to the lung from the parental HuO9 cells by in vivo selection. There were no differences between these two sublines and the parental cells in the growth rate in vitro and the tumorigenicity after subcutaneous injection in nude mice, however, mice injected with the metastatic sublines became
moribund earlier than mice injected with the parental HuO9 cells did. Thus, adriamycin (ADR) and recombinant interleukin-12
(IL-12) were administered to mice injected with the HuO9-M112 subline to suppress experimental lung metastases. Production
of lung colonies was significantly suppressed and the prognoses of mice were significantly improved by both ADR and IL-12
treatments. These results indicate that both ADR and IL-12 are effective agents against pulmonary metastatic osteosarcoma,
and that these sublines are useful for studies on the biological behavior and treatment of pulmonary metastatic osteosarcoma.
This revised version was published online in July 2006 with corrections to the Cover Date. 相似文献
6.
对 6 8例原发性三叉神经痛患者施行阿霉素神经干注射治疗。全部病例均在术后 2周内三叉神经痛症状消失 ,其中 6 3.2 %在术后 2 4h内痛疼消失 ;2 8.9%在术后 1周内疼痛消失 ;7.9%在术后 2周内疼痛消失。随访结果显示 ,3年内复发率为 10 .3% ,3~ 5年复发率为 15 .4%。该方法具有复发率低、疗效肯定、安全、微创等特点。 相似文献
7.
目的 观察茯苓对阴虚水肿模型大鼠的影响,研究茯苓利水作用特点及机制,并评价茯苓对阴虚水肿所表现出热象的影响。方法 尾iv阿霉素联合ig甲状腺片复制阴虚水肿模型大鼠,给予茯苓水煎液或六味地黄丸干预4周,观察大鼠水肿情况和一般生长状态,检测24 h尿量和尿蛋白,测量肛温,进行冷热板实验计算热板停留时间比;检测血清总蛋白(total cholesterol,TP)、白蛋白(albumin,Alb)、尿素氮(blood urea nitrogen,BUN)、肌酐(creatinine,Cr)、环磷酸腺苷(cyclic adenosine monophosphate,c AMP)、环磷酸鸟苷(cyclic guanosine monophosphate,c GMP)水平;测定肾组织超氧化物歧化酶(superoxide dismutase,SOD)活性及活性氧(reactive oxygen species,ROS)、丙二醛(malondialdehyde,MDA)水平;苏木素-伊红(HE)染色观察肾组织病理变化;Western blotting检测肾脏组织Klotho和棕色脂肪组织中解偶联蛋白1... 相似文献
8.
Magnetic albumin microspheres entrappingadriamycin ( ADM- MAM) is a novel chemothera-peutic compound with site- specific drug delivery,which was exploited and developed in 1 970 's[1] .However,there wasno detailinformation indexed onits toxicity[2 ] . In recentyears,we studied the toxici-ty of the compounds macroscopically and microscopi-cally and also gotits value of LD50 .1 METHODSAND RESULTSBased on the method previously reported[1] ,thecompound of ADM- MAM was synthesized[14 ]… 相似文献
9.
生脉注射液对阿霉素致心脏损伤保护作用的实验研究 总被引:4,自引:0,他引:4
用Wister大鼠模型研究生脉注射液对阿霉素致心脏损伤的保护作用。结果:使用生脉注射液比单纯使用阿霉素,血清SOD活性升高,MDA、GOT、LDH、HBDH、LDH1/LDH2比值及心肌病理计分下降。表明;生脉注射液对阿霉素导致的心脏损伤具有保护作用,其机理与其清除氧自由基,保护SOD活性有关。 相似文献
10.
丹参及生脉液对阿霉素所致大鼠肾小球硬化的实验性治疗作用 总被引:4,自引:0,他引:4
观察丹参及生脉液对阿霉素所致 S D 大鼠肾小球硬化实验性治疗作用。摘除大鼠左肾7 d 后,尾静脉注射阿霉素(6 m g·kg - 1) 。隔日腹腔注射丹参及生脉液,8 周后处死大鼠。观察血红蛋白( Hb) 、血尿素氮( B U N) 、胆固醇( Ch) 及24 h 尿蛋白含量; E L I S A 法测定肾皮质Ⅳ型胶原( Ⅳcol .) 及层粘连蛋白( L N) ;用免疫组化法,计算机图象分析肾小球系膜区Ⅳcol .及 L N 含量。结果显示:模型丹参及模型生脉液组肾皮质、肾小球系膜区Ⅳcol.及 L N 含量明显低于模型对照组( P < 0 .05) ,高于正常对照组( P < 0 .01) 。提示丹参及生脉液能减轻阿霉素所致肾小球硬化的程度。 相似文献