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目的 了解西安地区育龄妇女TORCH感染的流行病学特征,为优生优育提供参考依据。方法 应用化学发光免疫法检测14094名育龄妇女TORCH抗体IgM和IgG,从季节、年龄、户籍等方面进行流行病学分析,采用SPSS 20.0软件对数据进行卡方(χ2)检验。结果 TORCH - IgG阳性率大于80%的病毒为CMV(90.90%)、RV(83.59%)、HSV I(82.95%)。TORCH - IgM阳性率分别为 CMV(2.31%)、RV(1.42%)、HSV I(0.22%)、HSV II(0.15%)、TOX(0.12%)。不同年龄组TOX - IgM(χ2 = 8.20,P = 0.017)、CMV - IgM(χ2 = 7.55,P = 0.023)、HSV II - IgM(χ2 = 6.74,P = 0.034)阳性率差异有统计学意义;不同季节组RV - IgM(χ2 = 10.40,P = 0.015)阳性率差异有统计学意义;不同户籍组TOX - IgM(χ2 = 5.13,P = 0.024)、CMV - IgM(χ2 = 5.28,P = 0.022)阳性率差异有统计学意义。结论 RV和HSV I对西安地区育龄妇女威胁较小,而TOX、HSV II和CMV威胁较大;其中,年龄因素影响TOX、CMV、HSV II感染,季节因素影响RV感染,户籍因素影响TOX、CMV感染,因此,为进一步降低新生儿出生缺陷率,需加强该地区育龄妇女TORCH感染筛查。 相似文献
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先天性心脏病患者B19等病原感染的调查研究 总被引:9,自引:0,他引:9
Objective To explore relationship of Parvovirus B19(B19), Toxoplasma
gondii(TOX), rubella virus(RV), cytomegalovirus (CMV) or herpes simplex virus type-2
(HSV-2) infection with congenital heart disease (CHD). Methods We conducted a
case-control study on detection of B19, TOX, RV, CMV or HSV-2 gene in cardiac tissue of 66
cases of CHD and 38 cases controls with polymerase chain reaction (PCR). Results 1) The positive rates of
B19, TOX, CMV and HSV-2 in 66 cases CHD were 18.2%, 15.2%, 25.8% and 4.5%, respectively,
while that in 38 cases control groups were 0%, 2.6%, 21.2% and 2.6%, reapectively. The
positively of B19, TOX was significantly different (P<0.05) between CHD and control
groups, while no statistical difference (P<0.05) for CMV and HSV-2. 2) Seven of 30
(23.3%) CHD were positive for RV-RNA, compared with control group which was all negative
(P=0.0327). Conclusion The results show that B19, TOX, RV infection mighet be
important risk factors for CHD, while CMV and HSV-2 had no relationship with CHD. 相似文献
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