全文获取类型
收费全文 | 3429篇 |
免费 | 267篇 |
国内免费 | 43篇 |
专业分类
耳鼻咽喉 | 35篇 |
儿科学 | 37篇 |
妇产科学 | 97篇 |
基础医学 | 218篇 |
口腔科学 | 128篇 |
临床医学 | 591篇 |
内科学 | 725篇 |
皮肤病学 | 32篇 |
神经病学 | 89篇 |
特种医学 | 150篇 |
外科学 | 588篇 |
综合类 | 211篇 |
一般理论 | 2篇 |
预防医学 | 520篇 |
眼科学 | 48篇 |
药学 | 217篇 |
中国医学 | 10篇 |
肿瘤学 | 41篇 |
出版年
2024年 | 4篇 |
2023年 | 78篇 |
2022年 | 150篇 |
2021年 | 209篇 |
2020年 | 210篇 |
2019年 | 201篇 |
2018年 | 189篇 |
2017年 | 141篇 |
2016年 | 133篇 |
2015年 | 143篇 |
2014年 | 264篇 |
2013年 | 370篇 |
2012年 | 155篇 |
2011年 | 201篇 |
2010年 | 144篇 |
2009年 | 144篇 |
2008年 | 135篇 |
2007年 | 132篇 |
2006年 | 107篇 |
2005年 | 84篇 |
2004年 | 74篇 |
2003年 | 68篇 |
2002年 | 48篇 |
2001年 | 45篇 |
2000年 | 35篇 |
1999年 | 28篇 |
1998年 | 32篇 |
1997年 | 19篇 |
1996年 | 23篇 |
1995年 | 16篇 |
1994年 | 17篇 |
1993年 | 14篇 |
1992年 | 20篇 |
1991年 | 16篇 |
1990年 | 14篇 |
1989年 | 11篇 |
1988年 | 8篇 |
1987年 | 6篇 |
1986年 | 8篇 |
1985年 | 7篇 |
1984年 | 13篇 |
1983年 | 3篇 |
1982年 | 5篇 |
1981年 | 3篇 |
1980年 | 6篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1976年 | 3篇 |
排序方式: 共有3739条查询结果,搜索用时 31 毫秒
1.
《Biomaterials》2015
Bacterial infection of subcutaneous “pockets” housing cardiovascular implantable electronic devices is a significant clinical complication. In this study, pacemakers encapsulated in a blood plasma-based material (PBM) composited with antibiotics were investigated for use as prophylactics against such infections. PBMs, which are made from pooled allogeneic plasma and platelets, are off-the-shelf biomaterials that can be manufactured in the form of complex 3D shapes, extrudable putties, or injectable pastes. In vitro studies with PBM pastes formulated with rifampicin and minocycline demonstrated antibiotic release over 6 days, activity against Escherichia coli, and reduced cytotoxic effects of the antibiotics on fibroblasts. The materials were also evaluated in vivo in a rabbit model in which pacemaker pockets were inoculated with methicillin-resistant Staphylococcus aureus (S. aureus) strain and examined 1 week later. The pockets containing the pacemaker plus S. aureus were grossly purulent and culture positive, whereas pockets into which PBM with antibiotics were injected around the pacemaker were free of purulence and culture negative (p < 0.001). None of the pockets into which PBM without antibiotics were placed demonstrated purulence, but 60% were culture positive. These results demonstrate the potential of PBMs to deliver antibiotics to diminish the incidence of pocket infections for pacemakers and other implantable devices. 相似文献
2.
Purpose: To describe how central venous access devices (CVADs) are utilized for ambulatory oncology patients and to evaluate the rate of complications. Method: Single institution retrospective study of oncology patients with CVADs who received systemic treatment at the Walker Family Cancer Centre (WFCC) between 1 January and 31 December 2018. Results: A total of 480 CVADS were placed in 305 patients, of which 408 (85%) were peripherally inserted central catheters (PICCs) and 72 (15%) were implanted vascular access devices (PORTs). The incidence of early and late complications was 9% and 24%, respectively. For the entire cohort, the rate of venous thromboembolism (VTE) was 16%, of which 9% were CVAD-related thrombosis (CRTs) and 7% were distant VTE. The CRT rates were similar for PICCs and PORTs (9% vs. 7%). A total of 6% of CVADs were complicated by infection (i.e., localized infections and bacteremia), with a total infection rate of 0.43 and 0.26 per 1000 indwelling days for PICCs and PORTs, respectively. The incidence of central line associated bloodstream infections (CLABSI) was greater for PICCs than PORTs, at a rate of 0.22 compared with 0.08 per 1000 indwelling days, respectively. The premature catheter removal rate was 26% for PICCs and 18% for PORTs. PORTs required more additional hospital visits. Conclusions: PICCs were utilized more frequently than PORTs and had a higher rate of premature removal. The rates of VTE and CRT were similar for both CVAD types. PORTs had a lower rate of infection per 1000 indwelling days. However, the management of PORT related complications required more visits to the hospital and oncology clinic. 相似文献
3.
4.
5.
Walid K. Abu Saleh Phillip Mason Odeaa Al Jabbari Hany Samir Brian A. Bruckner 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2015,42(6):569-571
The Impella 5.0, a percutaneously inserted left ventricular assist device, has been used to support patients who have severe heart failure or who are undergoing high-risk percutaneous coronary intervention. We report our surgical placement of the Impella 5.0, through a graft sewn to the aorta, to unload the left ventricle of a 59-year-old man who was undergoing venoarterial extracorporeal membrane oxygenation for postcardiotomy shock. The patient underwent successful placement of a long-term left ventricular assist device before his discharge from the hospital. The versatility of the Impella 5.0 is exemplified in this patient who was successfully bridged to long-term support. 相似文献
6.
7.
8.
9.
A new implantable bladder volume-monitoring device based on the impedance measurement of the detrusor muscle is described.
The system is completely autonomous and forms a mixed-signal (analogue/digital) feedback loop with a neuro-stimulator to rectify
bladder dysfunctions (incontinence and retention) through neuromuscular stimulation techniques. A programmable instrumentation
amplifier and a signal processing block, to eliminate the artefacts caused by the patient’s movements, have been designed
and tested. The layout for the signal processing block has been realised in 0.8 μm BiCMOS technology. 相似文献
10.
William P. Grant DPM Laurence G. Rubin DPM Guy R. Pupp DPM George Vito DPM Dwayne Jacobus DPM Erin A. Jerlin DPM Harry S. Tam DPM 《The Journal of foot and ankle surgery》2007,46(5):325-335
The purpose of this study was to assess 7 methods of fixation for a midtarsal osteotomy. Polyurethane foam models (N = 6) and cadaver specimens (N = 4-7) were used to examine the force generated by the different constructs of fixation. A midtarsal osteotomy was performed on each specimen in the test groups. The osteotomies were fixated either with 2 parallel 0.062-in Kirschner wires and 40-mm-long, 4-mm partially threaded, cancellous, cannulated titanium screws, an external ring fixator (frame), a frame with wires tensioned (tension), a frame with wires tensioned and compressed toward the osteotomy (tension and compression), a frame with tension, compression, and parallel Kirschner wires, or a frame with tension, compression, and two 4.0 cannulated parallel screws, respectively. Each model was fixated, and the force generated by the construct across the osteotomy was recorded via the use of pressure-sensitive film. Statistical analysis of the data in the polyurethane foam group determined that the use of frame with tension, compression, and two 4.0 parallel cannulated screws was statistically superior to 1) frame, 2) frame with tension, 3) 2 parallel Kirschner wires, 4) two 4.0 cannulated parallel screws, and 5) frame with tension and compression. A cadaver study determined that the frame with tension, compression, and 2 parallel Kirschner wires was statistically superior to 1) frame and 2) two parallel Kirschner wires. These findings suggest that there is a difference in the force generated by the type of fixation construct across a midtarsal osteotomy. 相似文献