全文获取类型
收费全文 | 814篇 |
免费 | 43篇 |
国内免费 | 53篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 30篇 |
妇产科学 | 16篇 |
基础医学 | 70篇 |
口腔科学 | 7篇 |
临床医学 | 85篇 |
内科学 | 241篇 |
皮肤病学 | 7篇 |
神经病学 | 115篇 |
特种医学 | 22篇 |
外科学 | 115篇 |
综合类 | 115篇 |
预防医学 | 15篇 |
眼科学 | 11篇 |
药学 | 25篇 |
中国医学 | 13篇 |
肿瘤学 | 15篇 |
出版年
2024年 | 2篇 |
2023年 | 15篇 |
2022年 | 42篇 |
2021年 | 47篇 |
2020年 | 38篇 |
2019年 | 47篇 |
2018年 | 41篇 |
2017年 | 31篇 |
2016年 | 38篇 |
2015年 | 31篇 |
2014年 | 59篇 |
2013年 | 56篇 |
2012年 | 25篇 |
2011年 | 46篇 |
2010年 | 34篇 |
2009年 | 51篇 |
2008年 | 52篇 |
2007年 | 49篇 |
2006年 | 35篇 |
2005年 | 28篇 |
2004年 | 17篇 |
2003年 | 18篇 |
2002年 | 15篇 |
2001年 | 6篇 |
2000年 | 8篇 |
1999年 | 5篇 |
1998年 | 5篇 |
1997年 | 6篇 |
1996年 | 5篇 |
1995年 | 7篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1992年 | 4篇 |
1991年 | 7篇 |
1990年 | 5篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 4篇 |
1985年 | 4篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1981年 | 3篇 |
1980年 | 1篇 |
1979年 | 4篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1976年 | 1篇 |
排序方式: 共有910条查询结果,搜索用时 0 毫秒
1.
Experimental studies demonstrated a severe cardiac load of the CO2 pneumoperitoneum caused by an accelerated after- and a decreased preload. Patients displaying cardiovascular risks are therefore
often rejected from laparoscopic surgery. Hence, the pathophysiological changes and the intraoperative risk of the CO2 pneumoperitoneum in high-risk cardiopulmonary patients (NYHA II–III, n= 15) undergoing laparoscopic cholecystectomy are described. The changes in cardiac after- and preload seem to be due to the
elevated intraabdominal pressure rather than transperitoneally resorbed CO2 and are reversible by desufflation. In one patient conversion to open operation had to be performed because of a severe drop
in cardiac output and right ventricle ejection fraction. Mixed oxygen saturation was predicting intraoperative worsening in
this case. The described pathophysiological changes may seem to be well tolerated even in high-risk cardiac patients. Monitoring
of hemodynamics should include an arterial catheter line and blood gas analyses. Pharmacologic interventions or pressureless
laparoscopic procedures might not be necessary as long as laparoscopic cholecystectomy is performed.
Received: 13 December 1996/Accepted: 8 January 1997 相似文献
2.
Management of abdominal sepsis 总被引:2,自引:0,他引:2
D. Berger K. Buttenschoen 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》1998,383(1):35-43
Introduction: Today the management of the different forms of peritonitis is generally standardised. The classification of primary and secondary
peritonitis is well accepted. From a pathophysiological point of view, postoperative and post-traumatic peritonitis should
be considered as independent entities. The bacteriological isolates from the inflamed peritoneal cavity do not correlate with
the clinical course, and the occurrence of enterococci and bacteroides may be slightly related to ongoing infectious complications.
Classification: Valuable scoring systems mainly rely on systemic signs of the septic disease and seem to better differentiate the prognosis
of the disease than more surgically oriented scores do. Although the scoring systems did not allow any clinical decision,
they should be used to help better compare patients treated in different institutions. The observation of the minor relevance
of bacteriology and the superiority of general sepsis scores agrees with the fact that pre-existing septic organ dysfunction
and pre-existing comorbidity are the main determinants of mortality. Treatment: Surgical therapy focuses on the control of the source of infection because it has been clearly shown that, without resolving
the source of infection, the prognosis remains poor. Adjuvant surgical measures aim at the further reduction of the bacterial
load in the peritoneal cavity. Planned relaparotomy, relaparotomy on demand, and continuous closed peritoneal lavage are used.
Results: Clinical results proved these methods to be equally effective although pathophysiological considerations favour closed peritoneal
lavage. Conclusion: Summarising the available data, we need a more sophisticated understanding of the pathophysiology of the peritonitis, and
well-designed clinical studies are necessary to define the optimal surgical treatment modalities.
Received: 27 November 1997 相似文献
3.
中国病理生理杂志第6—10卷论著的引文分析与比较 总被引:1,自引:0,他引:1
林影 《中国病理生理杂志》1995,11(6):562-566
中国病理生理杂志于1985年创刊,是目前国内唯一的病理生理学科高级学术刊物。本文对该刊第6-10卷所发表的论著做出版周期和引文分析。 相似文献
4.
Transport of organic cations (OC) is important for the recycling of endogenous OC and also a necessary step for detoxification of exogenous OC in the body. Even though the identification and characterisation of numerous OC transporters in recent years has allowed the elucidation of molecular mechanisms underlying OC transport, elucidation of the regulation of this transport is just beginning. This review summarises the general properties of OC transport and then analyses the literature on the regulation of these processes. Studies on short- and long-term regulation of OC transport are considered separately. Important aspects of short-term regulation have been clarified and the regulatory pathways of several OC transporters have been characterised. Short-term regulation appears to be transporter subtype-, tissue- and species-dependent and to involve transporter phosphorylation. Transporter phosphorylation may alter the affinity for substrates or/and expression on the plasma membrane. Even though several studies have shown long-term regulation of OC transport, the pathophysiological meaning of these changes are not well understood. In this case, regulation seems to be subtype-, tissue- and gender-specific. Further research is necessary to clarify this important issue of regulation of OC transport. 相似文献
5.
6.
Important inroads are being made into understanding the pathophysiology of diarrhea. Clear understanding of key mechanisms
should suggest new approaches to combat disease. Exciting developments are occurring in terms of super-ORS solutions, particularly
with the promise of short chained glucose polymers and glutamine. Perhaps the most important development is the prospect of
a good rotavirus vaccine being available before the end of the decade.
Chronic diarrhea seems to be on the increase globally, probably because of the success of ORS. The mechanisms that lead to
mucosal injury are elusive, and therapy still largely supportive and empiric. Celiac disease continues to be a puzzle, because
of the uncomfortable feeling that a majority of cases may be missed because of atypical presentations. The successful use
of long term parenteral nutrition has allowed survival and better charaterization of cases that otherwise would have perished
as ‘lethal protracted diarrhea’. Microvillus inclusion disease may be the commonest congenital secretory diarrhea. The role
of the recently reported high prevalence of glucoamlase deficiency may be important. Lastly, attention to micronutrients,
particularly low vitamin A and probably zinc may prove to be important in prevention and amelioration of diarrhea and growth
failure. 相似文献
7.
The drugs used in migraine therapy can be divided into two groups: agents that abort an established migraine attack and agents used prophylactically to reduce the number of migraine attacks. Both groups have drugs that are specific for migrainous headaches and that are non-specific, and are used to treat the accompanying headache (analgesics), vomiting (anti-emetics), anxiety (sedatives and anxiolytics), or depression (antidepressants). The main drugs with specific action on migraine include ergot alkaloids (ergotamine, dihydroergotamine), agonists (sumatriptan) or partial agonists (methysergide) at a specific subtype of 5-HT1-like receptors, -adrenoceptor antagonists (propranolol, metoprolol), calcium antagonists (flunarizine) and anti-inflammatory agents (indomethacin). The pharmacological basis of therapeutic action of several of these drugs is not well understood. In the case of the ergot alkaloids and 5-HT1-like receptor agonists, however, it is likely that the antimigraine effect is related to the potent and rather selective constriction of the large arteries and arteriovenous anastomoses in the scalp and dural regions. In addition, these drugs inhibit plasma extravasation into the dura in response to trigeminal ganglion stimulation, but it is possible that this effect is related to the selective vasoconstriction in the extracerebral vascular bed. The selectivity of the pharmacological effects of these antimigraine drugs (constriction of the extracerebral arteries and arteriovenous anastomoses, poor penetration into the central nervous system and the absence of an antinociceptive effect even after intrathecal administration) strongly suggests that excessive dilatation in the extracerebral cranial vasculature, probably initiated by a neuronal event, is an integral part of the pathophysiology of migraine. 相似文献
8.
Eugene Oteng-Ntim Charlotte Cottee Susan Bewley Elizabeth N. Anionwu 《Current Obstetrics & Gynaecology》2006,16(6):353-360
With advances in management, many women with sickle cell disease now survive to have children. The high risk of fetal and maternal sequelae mandates multidisciplinary management involving an obstetrician, a haematologist, an anaesthetist and a haemoglobinopathy specialist nurse. Hydroxyurea, a new treatment for sickle cell disease, is contraindicated in pregnancy. Exchange transfusion may be indicated in women with a serious obstetric or haematological complications. In those with sickle cell disease, the entire pregnancy is a high-risk period that warrants close monitoring. It is thus important for every obstetrician to be familiar with the condition. 相似文献
9.
三峡大学医学院病理生理学教研室在教学中,用病理生理学发展规律激发学生创新思维潜力,用临床实例帮助学生清除思维定势,用医学创新事例介绍探讨学生创新思维培养方法;通过总结相关经验,以期为医学本科创新教育提供参考。 相似文献
10.
赵志钢 《中华医学教育探索杂志》2011,10(3):301-303
在病理生理学实验教学中应用虚拟实验,可增加教学的生动性与趣味性,充分调动学生的学习积极性,使其在虚拟的实验环境中较为真实地模拟完成实验;能有效缓解教学需求与现有实验条件不足的矛盾,促进教师教学观念的转变和教学方法的改进,并为学生带来崭新的学习方式. 相似文献