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1.
国产达美康治疗Ⅱ型糖尿病的临床观察 总被引:1,自引:0,他引:1
本文应用国产达美康对71例NIDDM患者进行了临床观察,同时以优降糖做对照。结果显示:达美康降糖效果与优降糖相当,降血脂方面优于优降糖,并可降低全血粘度,而对照组无此变化,提示达美康在降低血粘度、改善微循环、防治糖尿病性微血管病变上有它独特的作用。结果表明达美康是治疗NIDDM安全而有效的口服降糖药。 相似文献
2.
目的观察正常人的低密度脂蛋白(native low density lipoprotein,nLDL),人工氧化的低密度脂蛋白(oxidized lowdensity lipoprotein,ox-LDL)及非胰岛素依赖型糖尿病(Non-insulin dependent diabetes mellitus,MDDM)患者的低密度脂蛋白(diabetic low density lipoprotein,dLDL)对兔胸主动脉环内皮的损伤作用及左旋精氨酸(L-arginine,L-Arg),维生素B6(pyridoxine,VB6)的拮抗效应.方法采用离体动脉环灌流的方法,观察兔胸主动脉环对乙酰胆碱(acetycholine,Ach),钙离子载体A23187的舒张反应.结果3种LDL均抑制动脉环对Ach及A23187的舒张,损伤强度为ox-LDL>dLDL>nLDL,并具有浓度依赖性;L-Arg、VB6能明显拮抗LDL的抑制作用,但并不能完全逆转.以SOD作为保护药对照,250 U/ml的浓度能够显著抑制dLDL对内皮的损伤.结论3种低密度脂蛋白主要可能通过降低NO生物活性损伤内皮,L-Arg、VB6具有内皮保护作用. 相似文献
3.
Kiyoshi Hashizume Kazuo Ichikawa Satoru Suzuki Teiji Takeda Keishi Yamauchi Mutsuhiro Kobayashi Xiao-Yun MA 《Journal of bone and mineral metabolism》1992,10(2):39-49
Calorie restriction is important in managing patients with maturity onset diabetes mellitus (NIDDM). The effect of such restriction
on calcium metabolism is not known. The objective of this study was to determine whether patients on calorie restricted diets
would show any modification of parathyroid hormone (PTH) and calcitonin (CTN).
The serum levels of PTH and CTN were measured by radioimmunoassays in 269 patients with NIDDM. The patients were divided into
two groups depending on the intake of calorie, and PTH and CTN were monitored for 2 years. Plasma levels of vitamin D were
measured by competitive protein binding assays before and after each program.
The level of PTH (520.8±266.0 pg/ml) (mean±S.D.) was significantly (P<0.01) higher in 109 diabetic patients whose calorie intake was restricted for 2 years (diet (D) group) as compared with that
(256.6±103.8 pg/ml) of 160 diabetic patients whose calorie intake was not restricted (non-diet (ND) group). The daily oral
calcium intake of the two groups did not differ significantly. We found no significant difference in the serum PTH level in
the ND groupVS. normal control subjects (248.8±98.4, N=78). The serum calcium concentration and the amount of calcium excreted in urine
were slightly but significantly (P<0.01) lower in the D than in the ND group. The rate of tubular reabsorption of phosphate (% TRP) was significantly lower
in the D group than that in the ND group (P<0.01). The serum CTN level was significantly (P<0.01) lower in the D group (33.9±11.3 pg/ml) than in the ND group (64.9±21.2 pg/ml) 2 years after each treatment. The plasma
1,25-(OH)2-vitamin D level was significantly (P<0.01) lower in the D group (22.2±6.6 pg/ml) than in the ND group (50.6±4.2 pg/ml). When
the restriction of calorie intake in the D group was canceled, their PTH levels decreased, which was accompanied by increase
in the 1,25-(OH)2-vitamin D levels, whereas their CTN levels were unchanged.
These observations suggested that a restricted calorie intake is a risk factor for secondary hyperparathyroidism as well as
for a low serum level of CTN in patients with NIDDM. 相似文献
4.
观察了30例伴有高脂血症的Ⅱ型糖尿病患者用小剂量乐脂平(500mg/d)治疗4周后血清脂质、脂蛋白的变化。结果:血总胆固醇、甘油三酯及极低密度脂蛋白—胆固醇水平较治疗前下降,高密度脂蛋白—胆固醇明显升高,血糖、血肌酐及血尿酸无明显变化。服用该药未观察到不良反应,提示乐脂平能较好地改善糖尿病患者的脂代谢紊乱。 相似文献
5.
J. J. J. de Sonnaville M. Bouma L. P. Colly W. Devillé D. Wijkel R. J. Heine 《Diabetologia》1997,40(11):1334-1340
Summary In primary care it is difficult to treat the growing number of non-insulin-dependent diabetic (NIDDM) patients according
to (inter)national guidelines. A prospective, controlled cohort study was designed to assess the intermediate term (2 years)
effect of structured NIDDM care in general practice with and without ’diabetes service' support on glycaemic control, cardiovascular
risk factors, general well-being and treatment satisfaction. The ’diabetes service', supervised by a diabetologist, included
a patient registration system, consultation facilities of a dietitian and diabetes nurse educator, and protocolized blood
glucose lowering therapy advice which included home blood glucose monitoring and insulin therapy. In the study group (SG;
22 general practices), 350 known NIDDM patients over 40 years of age (206 women; mean age 65.3 ± SD 11.9; diabetes duration
5.9 ± 5.4 years) were followed for 2 years. The control group (CG; 6 general practices) consisted of 68 patients (28 women;
age 64.6 ± 10.3; diabetes duration 6.3 ± 6.4 years). Mean HbA1 c (reference 4.3–6.1 %) fell from 7.4 to 7.0 % in SG and rose from 7.4 to 7.6 % in CG during follow-up (p = 0.004). The percentage of patients with poor control (HbA1 c > 8.5 %) shifted from 21.4 to 11.7 % in SG, but from 23.5 to 27.9 % in CG (p = 0.008). Good control (HbA1 c < 7.0 %) was achieved in 54.3 % (SG; at entry 43.4 %) and 44.1 % (CG; at entry 54.4 %) (p = 0.013). Insulin therapy was started in 29.7 % (SG) and 8.8 % (CG) of the patients (p = 0.000) with low risk of severe hypoglycaemia (0.019/patient year). Mean levels of total and HDL-cholesterol (SG), triglycerides
(SG) and diastolic blood pressure (SG + CG) and the percentage of smokers (SG) declined significantly, but the prevalence
of these risk factors remained high. General well-being (SG) did not change during intensified therapy. Treatment satisfaction
(SG) tended to improve. Implementation of structured care, including education and therapeutic advice, results in sustained
good glycaemic control in the majority of NIDDM patients in primary care, with low risk of hypoglycaemia. Lowering cardiovascular
risk requires more than reporting results and referral to guidelines. [Diabetologia (1997) 40: 1334–1340]
Received: 5 February 1997 and in revised form: 22 May 1997 相似文献
6.
7.
吴秋玲 《山西中医学院学报》2000,1(3):5-7
目的 :观察消渴灵冲剂对Alloxan糖尿病大鼠的治疗作用。方法 :设立高、低剂量组与西药二甲双胍组作对照 ,动态地观察大鼠FBG、IRI及血流变等指标。结果 :消渴灵可降低Alloxan糖尿病大鼠异常升高的FBG、GHb水平 ,升高空腹IRI水平 ,与治疗前相比差异显著 (P <0 .0 1)。其降糖作用与二甲双胍组相比无差异。消渴灵可降低Alloxan糖尿病大鼠异常升高的Hr、Lr、Br等血流变指标 ,对抗血液的高凝高粘状态 ,其疗效优于二甲双胍 (P <0 .0 1) ,消渴灵有助于糖尿病大鼠恢复体重。结论 :其机理可能在于促进胰岛 β细胞的分泌功能 ,升高血中IRI水平 ,增进细胞对葡萄糖的利用 ,增强免疫功能 ,改善营养状态 ,改善血流变等。 相似文献
8.
目的:探讨2型糖尿病患者骨密度改变及骨折发生率。方法:逆向随机选取住院骨折病人380例,测定骨密度改变,同时测定其血Ca,P,AKP,GLU,BGP浓度,并统计其中糖尿病的发生率及测定值对比情况。结果;骨折病人中的糖尿病患者机率为6.32%,骨折病人的骨密度改变在糖尿病组和非糖尿病组病人中有显著差异,和本区普查结果无显著差异。结论:糖尿病病人的骨折发生率和非糖尿病患者及无明显差异,但骨密度改变有明 相似文献
9.
H. Lind MD D. Erlinge MD PhD J. Brunkwall MD PhD L. Edvinsson MD 《Clinical autonomic research》1995,5(4):191-197
Vascular smooth muscle contractile responses to neuropeptide Y, ,ß-methyleneATP and noradrenaline were studied in circular segments of isolated vessels with intact endotheliumin vitro from 12 patients with diabetes mellitus type 2 (NIDDM) and 12 control subjects. The dilatory effect of acetylcholine was used to test the function of the endothelium. Subcutaneous arteries and veins (diameter 0.1–1.1 mm) were obtained during surgery. There was no difference in contractile responses to noradrenaline or ,ß-methyleneATP between diabetic and control vessels. The contractile response to neuropeptide Y, however, was markedly reduced in the diabetic group. The maximal contractile effect (46.0 ± 14.0%,p < 0.05) but not the sensitivity to neuropeptide Y was significantly less in diabetic veins compared to control (107.5 ± 19.6%). Thus, the attenuation of neuropeptide Y responses was present in humans as previously observed in alloxan-induced diabetes mellitus in rabbits. There was no difference in the dilator effect of acetylcholine between the diabetic and the control group in any of the vessel types, indicating that the difference in vascular reactivity to neuropeptide Y was not endothelium-dependent. In conclusion, the present study has shown that the postjunctional effects of neuropeptide Y, a co-transmitter of the peripheral sympathetic nervous system, is selectively attenuated in diabetes mellitus. 相似文献
10.