全文获取类型
收费全文 | 10084篇 |
免费 | 808篇 |
国内免费 | 481篇 |
专业分类
耳鼻咽喉 | 74篇 |
儿科学 | 99篇 |
妇产科学 | 97篇 |
基础医学 | 1885篇 |
口腔科学 | 134篇 |
临床医学 | 831篇 |
内科学 | 1518篇 |
皮肤病学 | 99篇 |
神经病学 | 317篇 |
特种医学 | 381篇 |
外科学 | 643篇 |
综合类 | 1506篇 |
预防医学 | 863篇 |
眼科学 | 59篇 |
药学 | 1071篇 |
1篇 | |
中国医学 | 570篇 |
肿瘤学 | 1225篇 |
出版年
2024年 | 38篇 |
2023年 | 181篇 |
2022年 | 459篇 |
2021年 | 487篇 |
2020年 | 387篇 |
2019年 | 452篇 |
2018年 | 407篇 |
2017年 | 347篇 |
2016年 | 379篇 |
2015年 | 418篇 |
2014年 | 664篇 |
2013年 | 643篇 |
2012年 | 494篇 |
2011年 | 676篇 |
2010年 | 401篇 |
2009年 | 506篇 |
2008年 | 496篇 |
2007年 | 507篇 |
2006年 | 463篇 |
2005年 | 427篇 |
2004年 | 350篇 |
2003年 | 308篇 |
2002年 | 279篇 |
2001年 | 250篇 |
2000年 | 183篇 |
1999年 | 145篇 |
1998年 | 140篇 |
1997年 | 119篇 |
1996年 | 98篇 |
1995年 | 88篇 |
1994年 | 83篇 |
1993年 | 62篇 |
1992年 | 50篇 |
1991年 | 50篇 |
1990年 | 50篇 |
1989年 | 44篇 |
1988年 | 30篇 |
1987年 | 21篇 |
1986年 | 17篇 |
1985年 | 44篇 |
1984年 | 35篇 |
1983年 | 19篇 |
1982年 | 20篇 |
1981年 | 20篇 |
1980年 | 8篇 |
1979年 | 8篇 |
1978年 | 5篇 |
1976年 | 4篇 |
1974年 | 2篇 |
1973年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
《Saudi Pharmaceutical Journal》2022,30(11):1572-1588
Non-alcoholic fatty liver disease (NAFLD) is one of the most common complications of a metabolic syndrome caused by excessive accumulation of fat in the liver. Orthosiphon stamineus also known as Orthosiphon aristatus is a medicinal plant with possible potential beneficial effects on various metabolic disorders. This study aims to investigate the in vitro inhibitory effects of O. stamineus on hepatic fat accumulation and to further use the computational systems pharmacology approach to identify the pharmacokinetic properties of the bioactive compounds of O. stamineus and to predict their molecular mechanisms against NAFLD. Methods: The effects of an ethanolic extract of O. stamineus leaves on cytotoxicity, fat accumulation and antioxidant activity were assessed using HepG2 cells. The bioactive compounds of O. stamineus were identified using LC/MS and two bioinformatics databases, namely the Traditional Chinese Medicine Integrated Database (TCMID) and the Bioinformatics Analysis Tool for the Molecular Mechanism of Traditional Chinese Medicine (BATMAN-TCM). Pathway enrichment analysis was performed on the predicted targets of the bioactive compounds to provide a systematic overview of the molecular mechanism of action, while molecular docking was used to validate the predicted targets. Results: A total of 27 bioactive compounds corresponding to 50 potential NAFLD-related targets were identified. O. stamineus exerts its anti-NAFLD effects by modulating a variety of cellular processes, including oxidative stress, mitochondrial β-oxidation, inflammatory signalling pathways, insulin signalling, and fatty acid homeostasis pathways. O. stamineus is significantly targeting many oxidative stress regulators, including JNK, mammalian target of rapamycin (mTOR), NFKB1, PPAR, and AKT1. Molecular docking analysis confirmed the expected high affinity for the potential targets, while the in vitro assay indicates the ability of O. stamineus to inhibit hepatic fat accumulation. Conclusion: Using the computational systems pharmacology approach, the potentially beneficial effect of O. stamineus in NAFLD was indicated through the combination of multiple compounds, multiple targets, and multicellular components. 相似文献
2.
3.
4.
John Bickle 《Topics in Cognitive Science》2015,7(2):299-311
David Marr's three-level method for completely understanding a cognitive system and the importance he attaches to the computational level are so familiar as to scarcely need repeating. Fewer seem to recognize that Marr defends his famous method by criticizing the “reductionistic approach.” This sets up a more interesting relationship between Marr and reductionism than is usually acknowledged. I argue that Marr was correct in his criticism of the reductionists of his time—they were only describing (cellular activity), not explaining (cognitive functions). But a careful metascientific account of reductionistic neuroscience over the past two decades reveals that Marr's criticisms no longer have force. Contemporary neuroscience now explains cognition directly, although in a fashion—causal-mechanistically—quite different than Marr recommended. So while Marr was correct to reject the reductionism of his day and offer an alternative method for genuinely explaining cognition, contemporary cognitive scientists now owe us a new defense of Marr's famous method and the advantages of its explanations over the type now pursued successfully in current reductionist neuroscience. There are familiar reasons for thinking that this debt will not be paid easily. 相似文献
5.
6.
《Clínica e investigación en ginecología y obstetricia》2022,49(2):100740
Preeclampsia is a disease with a significant incidence worldwide that is directly associated with 15% of maternal deaths. This is usually characterized by the presence of hypertension and proteinuria, which manifests itself from the middle of pregnancy. MicroRNAs are single-stranded RNA molecules that act primarily by degrading transcribed messenger RNA or inhibiting microRNA translation. Placental microRNAs play a role in the growth and function of the placenta, their potential use as diagnostic biomarkers is considered feasible due to the ability to enter the maternal circulation and be detectable in maternal plasma. 相似文献
7.
8.
9.
A. Armentia S. Martín-Armentia A. Moral D. Montejo B. Martin-Armentia R. Sastre S. Fernández A. Corell D. Fernandez 《Allergologia et immunopathologia》2019,47(4):350-356
Introduction and objectivesBiological aerosols play a vital role in the interactions between the atmosphere, biosphere, climate and public health and fungal spores are a component with allergic importance.We constructed a database in Castile & Leon (Spain) and carry out molecular-level component-resolved diagnosis to complete the air quality study carried out since 2006 by our aerobiological network (RACYL) to aid clinical diagnosis and treatment.MethodsWe reviewed a database of 19,774 patients (adults and children) with allergic respiratory disease treated in our unit during the last 12 years. We also made a component-resolved diagnosis of the molecules involved in the pathology in a randomly selected population of 150 patients.ResultsThe dimeric glycoprotein Alt a1 from Alternaria is the most prevalent and most useful allergen in the diagnosis of patients with allergy to fungi in our area (94.4%), followed by enolase Alt a 6 (Alternaria), ribonuclease Asp f 1 of Aspergillus and mannitol dehydrogenase from Cla h 8 (Cladosporium).ConclusionsOur results have helped determine which spore molecules are most-closely associated with allergies. Molecular analysis will be useful to determine more accurate and useful immunotherapy in these patients. 相似文献
10.
目的 克隆土耳其斯坦东毕吸虫磷酸丙糖异构酶的全长基因。方法 根据日本血吸虫和曼氏血吸虫磷酸丙糖异构酶基因的保守区设计引物,利用RT—PCR扩增出土耳其斯坦东毕吸虫磷酸丙糖异构酶基闪的大片段,再结合RACE技术分别得到磷酸丙糖异构酶基因的3’端和5’端,将3部分序列拼接后获得磷酸丙糖异构酶基因全长cDNA序列,并提交GenBank。结果 成功克隆了土耳其斯坦东毕吸虫磷酸丙糖异构酶基因全长cDNA序列并提交GenBank,登录号为DQ092331。结论 土耳其斯坦东毕吸虫磷酸丙糖异构酶基因全长cDNA的克隆为进一步表达及其生物学性能的分析提供了理论基础。 相似文献