高压氧对人重症牙周炎牙龈血流量、血流速度和血浓度作用及机理研究

目的 :探讨高压氧 (HBO)对人重症牙周炎牙龈血流量 (GBF)、血流速度 (BCV)和血浓度 (BC)的作用及HBO治疗牙周炎的机理。方法 :选自口腔中心门诊的 3 0例重症牙周炎患者 ,随机分为二组 ,即治疗组和对照组 ,治疗组用HBO治疗 ,对照组用漱口液漱口。用激光多普勒血流仪测定二组治疗前后的GBF、BCV和BC。结果 :HBO能使牙周炎患者GBF增加 2 .1倍 ,BCV增加 6.7倍 ,BC降低为治疗前的 5 8.2 % ,与对照组比均有非常显著性差异 (P <0 .0 1)。结论 :HBO能使牙周炎患者GBF和BCV增加 ,BC减少 ,能改善牙龈微循环 ,对治疗牙周炎有积极意义     

产学研结合下的协同创新机制探索

协同创新中心是发展人才、学科与科研的一种全新模式。在组织管理、人才培养、学科合作、项目分工和成果转移等均需大胆进行机制体制改革。参考美国、芬兰、日本等国家创新体系机制,可为协同创新中心建设提供借鉴。     

阵发性心房颤动机制的心内非接触式标测初步研究

目的　阵发性心房颤动 (paroxysmalatrialfibrillation ,PAF)的发生和维持机制仍不甚明了 ,尤其缺少人类在体的心内标测证据。本组采用心内非接触式标测技术观察PAF的机制并指导消融。方法　 15例患者 (男性 13例 ,女性 2例 ) ,年龄 34～ 6 6平均 (5 2± 9)岁 ,左心房 (leftatrium ,LA)内径 2 2～4 0 (32 6± 6 2 )mm。均经房间隔穿刺在LA内对PAF进行非接触式标测 ,观察冲动的传导 ,并在其指导下对关键的传导通路进行线性消融以终止PAF。结果　 15例中有 7例自发和 8例诱发的PAF ,等电位标测显示PAF时LA内的冲动大致可归纳为以单个折返性波阵面为主 (Ⅰ型 )和有 2个子波 (Ⅱ型 )的两种类型。其冲动的传导表现出总体的随机性与局部或一定时间相对有序相交织存在的特点。PAF平均周长(16 1 3± 2 0 0 )ms ,其中Ⅰ型PAF为 (16 5 4± 2 0 7)ms,Ⅱ型为 (15 3 3± 17 2 )ms,差异有显著性 (P <0 0 5 )。无论是自发还是诱发 (经冠状静脉窦远端 35 0～ 6 0 0次 /minS1S1刺激 )的PAF ,左、右肺静脉 (pulmonaryvein ,PV)口周围 ,LA上部及后壁均是折返或子波的主要传导通路。 4例PAF在LA上部可见明显的狭窄传导区 ,此处放电 3～ 13次平均 (7 0± 4 5 )次 (5 5～ 6 0℃ ,30s)即可终止PAF ;另有 7例在分别对左、     

Adrenocortical activation during long-term exercise in dogs: Evidence for a glucostatic mechanism

Summary Experiments were performed to elucidate the mechanism of changes in plasma 17-OHCS level during prolonged muscular exercise of moderate intensity. Dogs performed 120 min standard treadmill exercise. Plasma level of 17-OHCS increased during exercise. There was no change in the rate of removal of intravenously injected cortisol as compared with resting conditions. Exercise-dependent increase in plasma 17-OHCS level was prevented by continuous intravenous glucose infusion at a rate sufficient to prevent exercise hypoglycaemia. The same result was obtained when systemic hypoglycaemia persisted but glucose supply to the brain or liver was augmented by continuous glucose infusion to the carotid artery or portal vein. The same amount of glucose infused into a peripheral vein failed to abolish the adrenocortical response to exercise. The insulin-evoked hypoglycaemia of the magnitude comparable to that obtained during standard exercise did not significantly affect plasma 17-OHCS in resting animals.It is concluded that activation of glucocorticoid secretion during exercise is related to the glucostatic mechanism. Exercise hypoglacaemia per se is not responsible for adrenocortical activation. The results suggest that brain and hepatic glucoreceptors are engaged in the activation of the pituitary-adrenocortical system during exercise.     

臀肌挛缩伴骨盆倾斜症的发病机制及治疗

目的：分析伴骨盆倾斜的臀肌挛缩症的发病机制,。以此指导临床治疗,方法（1）1990年1月－2000年1月共收治臀肌挛缩症病人143例,其中伴骨盆倾斜患者31例,全部行手术治疗。术中重点探查臀大肌,臀中肌的挛缩情况并视具体情况行松解或肌腱延长术。（2）观察,分析臀部肌内解剖以探讨臀肌挛缩症病人发生骨盆倾斜的机制,结果：（1）经随访,手术后除1例遗留轻微踊行,1例遗留约6度骨盆倾斜外,余病人均步态正常,骨盆倾斜消失,达到临床治愈。（2）结合解剖学观察及术中所见,认为单纯臀大肌挛缩不会导致骨盆倾斜,臀中肌挛缩才会导致骨盆倾斜。结论：臀中肌挛缩是伴骨盆倾斜的臀肌挛缩症病人的发病机制,对此类病人只要早发现,治疗方法正确,均能取得良好的效果。