Ultrastructural and biochemical studies on the intestinal absorption of a medium-chain triglyceride (MCT), tricaprylin

The intestinal absorption of a medium-chain triglyceride (MCT) was studied by electron microscopy and biochemical analysis. In jejunal absorptive cells of rats fed tricaprylin, the smooth endoplasmic reticulum in the apical cytoplasm appeared to increase in number and contained one or two particles about 40–80 nm in diameter that were less electron dense and similar in size and profile to very low density lipoprotein. Similar particles were also observed packed in the dilated Golgi sacs and in the extended intercellular spaces. These particles were remarkably increased in number as compared with those in fasted rats. Biochemical analysis of lymph from the main intestinal lymph duct showed that caprylate was apparently demonstrated only in the lymph of rats given tricaprylin at the maximum rate 3h after oral administration. The study strongly suggests that medium-chain triglyceride is at least in part transported via lacteal, possibly in the form of very low density lipoprotein.     

A pilot study of an anti-MRSA bio-engineered lacteal complex (anti-MRSA BLC) in a murine septicemia model

Methicillin-resistant Staphylococcus aureus (MRSA) is an important pathogen of humans and other animals, causing septicemia, abcessation, toxemia, and other infectious diseases. Refined bioengineered lacteal complex (BLC), made specifically against MRSA, is a novel complex of low molecular weight immunogenic and antimicrobial molecules. It was evaluated in vivo using a mouse model of MRSA-induced peritonitis. Intraperitoneal dosing of anti-MRSA BLC demonstrated a therapeutic effect (83% survival) against an intraperitoneal MRSA challenge that caused 100% mortality in untreated animals. Anti-MRSA BLC is a promising therapeutic modality for MRSA infection.     

彩色多普勒超声对乳腺肿块良恶性鉴别诊断的价值

目的探讨二维超声及超声多普勒血流显像鉴别乳腺肿块的诊断价值。方法对166个乳腺肿块（良性肿块组117个,恶性肿块组49个,均经手术病理证实）进行超声检查,对比分析良、恶性肿块的二维超声特点、彩色血流情况及血流动力学参数的特征。结果与病理学检查结果对照,良、恶性肿块在二维超声图像上均有各自声像特征,在彩色多普勒检测中,82．1％（96／117）乳腺良性肿瘤内未探及血流信号,17．9％（21／117）在肿块周围测及少量血流信号,血流信号以I级为主,血流阻力指数0．44～0．66,91．8％（45／49）乳腺恶性肿瘤肿块内可以探及血流信号,血流信号以Ⅱ～Ⅲ级为主,血流阻力指数0．63—0．95。结论彩色多普勒超声作为安全、无创的检查方法,对乳腺肿块的定性诊断准确性较高,可清晰显示肿块的二维声像图特点和血流特征,对乳腺肿块的鉴别均有重要临床应用价值。     

彩色多普勒超声对乳腺良恶性肿块诊断的价值

目的应用彩色多普勒观测乳腺肿块的血流特点,评价其在鉴别乳腺良恶性肿块方面的意义。方法应用高频彩色多普勒对135例156个乳腺肿块进行扫查,观察肿块的彩色血流信号、血流分布部位及血流参数,与手术病理结果对照分析。结果恶性组血流检出率明显高于良性组,前者以Ⅱ、Ⅲ级为主,后者以0、Ⅰ级为主;良性组血流分布以周边及内部血流为主;恶性以穿入及内部血流为主;良性组的峰值流速及阻力指数均明显低于恶性组。结论彩色多普勒超声是鉴别乳腺良恶性肿块的重要指标。     

乳腺浸润性导管癌和纤维腺瘤的超声诊断

目的分析并探讨乳腺浸润性导管癌和纤维腺瘤的超声诊断及鉴别诊断要点。方法回顾性分析76例乳腺浸润性导管癌和乳腺纤维腺瘤的二维声像图特征及彩色多普勒特征,均经手术病理证实。结果乳腺浸润性导管癌大多表现为形态不规则、边界不清、内回声不均匀、后方回声有衰减、部分有沙粒样钙化及蟹足样改变,彩色多普勒血流分级大多为Ⅱ～Ⅲ级,RI〉0．70。乳腺纤维瘤大多表现为形态规则、边界清、内回声均匀、后方回声增强,彩色多普勒血流分级大多为0～I级,RI〈0．70。结论乳腺浸润性导管癌和乳腺纤维腺瘤可以通过二维超声及彩色多普勒超声加以诊断及鉴别诊断。     

梯度压力治疗仪对预防乳腺癌术后患肢淋巴水肿的效应

目的探讨运用梯度压力治疗仪对乳腺癌术后患肢淋巴水肿的发生与功能恢复作用。方法将100例Ⅱ～Ⅲ期乳腺癌且行乳腺癌改良根治术后康复患者随机分为对照组和试验组,各50例。2组均行常规乳腺癌术后护理并由专业护士指导按照临床康复路径进行康复锻炼,试验组配合梯度压力治疗仪治疗护理。观察2组患肢周长及肩关节活动度。结果试验组患者淋巴水肿发生率明显低于对照组(p<0.01);肩关节前屈、后伸、外展及内收的活动范围显著增加(p<0.01)。结论梯度压力治疗仪运用于乳腺癌术后患者可明显降低患肢淋巴水肿的发生率,减轻患肢肌肉的疲劳,促进患肢功能恢复,提高生活质量。     

乳腺超声在妇女健康体检中的应用价值

目的探讨乳腺超声在妇女健康体检中对发现乳腺疾病的应用价值。方法以2009年在我院体检中心进行健康体检的女性为分析对象,进行分类、统计分析。结果 2 563例受检女性中,878例经超声检出有乳腺疾病,检出率达34.3%,其中乳腺增生占60.0%,居本次统计的首位;其次是乳腺囊肿、乳腺纤维腺瘤及单纯性乳管扩张,分别达15.6%、14.9%及7.7%等。结论将超声应用于女性健康体检或妇女病普查中,对患乳腺疾病的女性做到早期发现、早期诊断、早期治疗,对减少乳腺癌的发生有至关重要的作用。