全文获取类型
收费全文 | 2878篇 |
免费 | 230篇 |
国内免费 | 35篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 32篇 |
妇产科学 | 20篇 |
基础医学 | 325篇 |
口腔科学 | 871篇 |
临床医学 | 167篇 |
内科学 | 252篇 |
皮肤病学 | 16篇 |
神经病学 | 186篇 |
特种医学 | 112篇 |
外科学 | 458篇 |
综合类 | 194篇 |
现状与发展 | 1篇 |
预防医学 | 93篇 |
眼科学 | 14篇 |
药学 | 259篇 |
中国医学 | 72篇 |
肿瘤学 | 58篇 |
出版年
2023年 | 52篇 |
2022年 | 103篇 |
2021年 | 168篇 |
2020年 | 101篇 |
2019年 | 115篇 |
2018年 | 116篇 |
2017年 | 103篇 |
2016年 | 106篇 |
2015年 | 115篇 |
2014年 | 161篇 |
2013年 | 210篇 |
2012年 | 134篇 |
2011年 | 156篇 |
2010年 | 116篇 |
2009年 | 140篇 |
2008年 | 140篇 |
2007年 | 135篇 |
2006年 | 119篇 |
2005年 | 103篇 |
2004年 | 76篇 |
2003年 | 94篇 |
2002年 | 59篇 |
2001年 | 60篇 |
2000年 | 43篇 |
1999年 | 39篇 |
1998年 | 44篇 |
1997年 | 37篇 |
1996年 | 34篇 |
1995年 | 28篇 |
1994年 | 26篇 |
1993年 | 15篇 |
1992年 | 25篇 |
1991年 | 15篇 |
1990年 | 9篇 |
1989年 | 12篇 |
1988年 | 13篇 |
1987年 | 9篇 |
1986年 | 16篇 |
1985年 | 11篇 |
1984年 | 9篇 |
1983年 | 14篇 |
1982年 | 10篇 |
1981年 | 5篇 |
1980年 | 8篇 |
1979年 | 6篇 |
1978年 | 9篇 |
1977年 | 4篇 |
1975年 | 3篇 |
1974年 | 3篇 |
1972年 | 3篇 |
排序方式: 共有3143条查询结果,搜索用时 343 毫秒
1.
2.
《European journal of surgical oncology》2019,45(10):1812-1816
ObjectivesMeshes/matrices are commonly used in immediate breast reconstruction. There are few studies comparing biological and synthetic meshes and it is unknown what type of mesh gives the best long-term results. The aim of this study was to compare long-term health-related quality of life (HrQoL) and patient satisfaction in implant-based immediate breast reconstruction with a biological mesh (Surgisis®) with that of patients reconstructed with a synthetic mesh (TIGR ® Matrix Surgical Mesh).Material and methodsBoth cohorts were prospectively included and consecutively operated. Clinical data was collected. HrQoL was evaluated with EuroQoL-5 dimension – 3 levels questionnaire (EQ-5D-3L) and the Hospital Anxiety and Depression Scale (HADS) and the Breast-Q.Results and conclusionSeventy-one patients were operated on in the biological group and 49 in the synthetic group. The response rates were 75 and 84 per cent, respectively. Mean follow-up time was 74 months and 23 months, respectively. There were no statistical differences in satisfaction and quality of life between the two groups. Complications and radiation seem to lead to a lower satisfaction. Our findings could indicate that biological and synthetic meshes give an equal long-term result as regards patients’ perceived quality of life. 相似文献
3.
4.
目的 探究下颌磨牙区即拔即种的临床疗效。方法 选取2017年1月至2019年1月江门市口腔医院收治的60例需进行下颌磨牙区种植的患者随机分为A、B组,A组给予即拔即种,B组给予延期种植,比较两组留存率、浅蝶形骨吸收率、种植12个月后PIS指标及满意度进行评价。结果 随访12个月两组留存率均为100%,浅碟形骨吸收率A组前磨牙为16.67%、磨牙为22.22%,B组前磨牙为10.00%、磨牙为25.00%,差异均无统计学意义(P>0.05),A组植入30个种植体,60个牙间乳头,其中3度29个、2度24个、1度7个,B组植入30个种植体,60个牙间乳头,其中3度14个、2度24个、1度22个,A组牙间乳头PIS指标优于B组,且A组牙间乳头PIS评分(2.36±0.52)较B组(1.87±0.48)显著提高,差异均具有统计学意义(P<0.05),A组对治疗效果满意率为93.33%较B组66.67%显著提高,差异具有统计学意义(P<0.05)。结论 对于下颌磨牙区缺牙患者可采取即拔即种的方法修复,缩短缺牙时间,促进咬合和咀嚼功能恢复,舒适且美观,提高患者的满意度,值得在临床上推广。 相似文献
5.
C Edward Hoffler Kurt D Hankenson Joshua D Miller Sukhinderdeep K Bilkhu Steven A Goldstein 《Journal of orthopaedic research》2006,24(8):1687-1698
To understand in situ behavior of osteocytes, we characterized a model of osteocytes in their native bone matrix and demonstrated real-time biologic activity of osteocytes while bending the bone matrix. Using 43 male Sprague-Dawley rats, dumbbell-shaped explants were harvested from stainless steel femoral implants after 6-12 weeks and incubated in culture medium or fixed. Sixteen specimens were used to determine bone volume density (BV/TV), volumetric bone mineral density (BMD) and histology for different implantation periods. Osteocyte viability was evaluated by L-lactate dehydrogenase (LDH) activity in 12 cultured explants. Confocal microscopy was used to assess tracer diffusion in three explants and changes in osteocyte pH of a mechanically loaded explant. From 6 to 12 weeks, explant BV/TV and volumetric BMD trended up 92.5% and 101%, respectively. They were significantly and highly correlated. Tissues were uniformly intramembranous and all bone cell types were present. Explants maintained LDH activity through culture day 8. Diffusion at 200 microM was limited to 1,209 Da. Explants appeared capable of reproducing complex bone biology. This model may be useful in understanding osteocyte mechanotransduction in the context of a physiologically relevant bone matrix. 相似文献
6.
T. M. Skerry M.D. M.R.C.V.S. R. Suswillo A. J. El Haj N. N. Ali R. A. Dodds L. E. Lanyon 《Calcified tissue international》1990,46(5):318-326
Summary Previous studies of Alcian blue-induced birefringence in adult avian cortical bone showed that a short period of intermittent
loading rapidly produces an increased level of orientation of proteoglycans within the bone tissue. In the absence of further
loading, this persists for over 24 hours. We have proposed that this phenomenon could provide a means for “capturing” the
effects of transient strains, and so provide a persistent, constantly updated strain-related influence on osteocyte populations
related to the bones' averaged recent strain history, in effect, a “strain memory” in bone tissue. In our present study, we
use the Alcian blue-induced birefringence technique to demonstrate that proteoglycan orientation also occurs after intermittent
loading of both cortical and cancellous mammalian bonein vivo andin vitro. We also show that the change in birefringence is proportional to the magnitude of the applied strain, and that the reorientation
occurs rapidly, reaching a maximal value after only 50 loading cycles. Examination of electron micrographs of bone tissue
after staining with cupromeronic blue allows direct visualization and quantification of the change in proteoglycan orientation
produced by loading. This shows that intermittent loading is associated with a realignment of the proteoglycan protein cores,
bringing them some 5 degrees closer to the direction of collagen fibrils in the bone matrix. 相似文献
7.
John R. Jarrett M.D. 《Aesthetic plastic surgery》1990,14(1):87-92
Immediate reconstruction of more than 1000 breasts was performed on high-risk patients on whom a prophylactic mastectomy was done. The mastectomy removes as much breast tissue as possible while leaving sufficient skin, and possibly the nipple-areola complex, to enable immediate reconstruction. The creation of symmetrical, well-balanced muscle pockets for the implant is the most important factor in producing satisfactory results in these cases. 相似文献
8.
V. Jacomella A. Sauser A. C. Truttmann B. V. Kuhlmann-Siegenthaler S. Capillo M. G. Bianchetti 《Acta diabetologica》1997,34(3):235-237
The recognized existence of a circadian pattern in extracellular magnesium balance might mirror either an inherent rhythm
in the homeostasis of this ion or dietary factors. Since in vitro insulin enhances cellular magnesium uptake, the circadian
rhythm in extracellular magnesium metabolism might be modulated at least in part by carbohydrate intake. To assess this hypothesis,
the effects of oral glucose loading on plasma total and ionized magnesium were investigted in lean healthy humans with a negative
family history for essential hypertension and diabetes mellitus. Plasma total and ionized magnesium was similar before glucose
loading and 30, 60, 90, 180, and 210 min thereafter. It is therefore concluded that in healthy humans the circadian pattern
of extracellular magnesium is not modulated by the metabolic and hormonal mechanisms that adjust the concentration of glucose.
Received: 5 February 1997 / Accepted in revised form: 14 April 1997 相似文献
9.
选择南方热区某特种部队战士52人,分两组分别口服5mgVitB1和VitB2,收集4h尿液,用荧光法进行负荷试验。结果:VitB1组,所测29人中,15人缺乏,9人不足,2人正常,3人充裕;VitB2组,所测23人中,11人缺乏,12人不足,反映该部队全年约5%的发病是由于VitB1、VitB2缺乏不足所致。其原因为膳食摄入不够 相似文献
10.
We tested the ability of normal subjects to make changes in the conjugacy of their saccades. Subjects dichoptically viewed a grid the size of which was 10% larger in one eye. The grids were centred onto a flat screen at 57 cm or 1 m from the subject. Horizontal saccades immediately became larger in the eye viewing the larger grid. For some subjects this disconjugacy persisted even under subsequent monocular viewing. Such persistent changes occurred mainly in the field where the required disconjugacy was divergent for centrifugal saccades, convergent for centripetal saccades. Vertical saccades also developed compensatory disconjugacy; its amplitude was smaller but less variable. To explain these results we propose a fast associative learning mechanism that pairs peripheral disparity with saccades and is capable of producing saccade disconjugacy even in the absence of disparity. For horizontal saccades a secondary conditioning of monocular depth cues by the disparity would also be involved. 相似文献