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Takanori Ito Taishi Takahara Natsuki Taniguchi Yuki Yamamoto Akira Satou Akiko Ohashi Emiko Takahashi Naoto Sassa Toyonori Tsuzuki 《Pathology international》2023,73(11):542-548
Clinical and genomic features of prostate cancer (PCa) vary considerably between Asian and Western populations. PTEN loss is the most frequent abnormality in intraductal carcinoma of the prostate (IDC-P) in Western populations. However, its prevalence and significance in Asian populations have not yet been well studied. In the present study, we evaluated PTEN expression in IDC-P in a Japanese population and its association with ERG expression. This study included 45 and 59 patients with PCa with and without IDC-P, respectively, who underwent radical prostatectomy. PTEN loss was observed in 10 patients with PCa with IDC-P (22%) and nine patients with PCa without IDC-P (17%). ERG expression was relatively frequent in patients with PCa with PTEN loss, although a significant difference was not observed. The co-occurrence of PTEN loss and ERG expression was observed in four patients with PCa with IDC-P and one without IDC-P. PTEN loss and ERG expression did not affect progression-free survival, regardless of the presence of IDC-P. The frequency of PTEN loss in IDC-P is lower in Asian patients than in Western patients. Our results indicate that mechanisms underlying IDC-P in Asian populations are different from those of Western populations. 相似文献
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Masashi Kato MD Akihiro Hirakawa PhD Yumiko Kobayashi Ms Akiyuki Yamamoto Ryo Ishida MD Tomoyasu Sano MD Tohru Kimura MD Tsuyoshi Majima MD Shohei Ishida MD Yasuhito Funahashi MD Naoto Sassa MD Takashi Fujita MD Yoshihisa Matsukawa MD Tokunori Yamamoto MD Ryohei Hattori MD Momokazu Gotoh MD Toyonori Tsuzuki MD 《The Prostate》2019,79(10):1065-1070
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Masashi Kato MD Akihiro Hirakawa PhD Yumiko Kobayashi Akiyuki Yamamoto MD Ryo Ishida MD Osamu Kamihira MD Tomoyasu Sano MD Tsuyoshi Majima MD Shohei Ishida MD Yasuhito Funahashi MD Naoto Sassa MD Takashi Fujita MD Yoshihisa Matsukawa MD Ryohei Hattori MD Momokazu Gotoh MD Toyonori Tsuzuki MD 《The Prostate》2020,80(3):284-290
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The concept of intraductal carcinoma of prostate (IDC-P) has evolved over the years and its clinicopathologic significance has come to be more clearly appreciated. In contrast to morphologically malignant intraductal lesions that represent earlier stages of the malignant process in other anatomic sites such as the breast, IDC-P has now been generally recognized as a prognostically unfavorable manifestation of later stage spreading of its invasive counterpart. We here briefly review the evolution of the IDC-P concept, the histological diagnostic criteria and differential diagnosis, the clinical significance, as well as recent molecular data of IDC-P. 相似文献
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