全文获取类型
收费全文 | 684篇 |
免费 | 40篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 54篇 |
妇产科学 | 9篇 |
基础医学 | 174篇 |
口腔科学 | 13篇 |
临床医学 | 77篇 |
内科学 | 49篇 |
皮肤病学 | 37篇 |
神经病学 | 12篇 |
特种医学 | 45篇 |
外国民族医学 | 3篇 |
外科学 | 125篇 |
综合类 | 36篇 |
预防医学 | 3篇 |
眼科学 | 6篇 |
药学 | 7篇 |
肿瘤学 | 88篇 |
出版年
2024年 | 1篇 |
2023年 | 15篇 |
2022年 | 26篇 |
2021年 | 36篇 |
2020年 | 39篇 |
2019年 | 26篇 |
2018年 | 26篇 |
2017年 | 27篇 |
2016年 | 16篇 |
2015年 | 29篇 |
2014年 | 45篇 |
2013年 | 35篇 |
2012年 | 18篇 |
2011年 | 44篇 |
2010年 | 31篇 |
2009年 | 24篇 |
2008年 | 33篇 |
2007年 | 35篇 |
2006年 | 29篇 |
2005年 | 22篇 |
2004年 | 17篇 |
2003年 | 23篇 |
2002年 | 12篇 |
2001年 | 11篇 |
2000年 | 10篇 |
1999年 | 12篇 |
1998年 | 8篇 |
1997年 | 8篇 |
1996年 | 7篇 |
1995年 | 10篇 |
1994年 | 1篇 |
1993年 | 4篇 |
1992年 | 8篇 |
1991年 | 7篇 |
1990年 | 5篇 |
1989年 | 11篇 |
1988年 | 4篇 |
1987年 | 5篇 |
1986年 | 3篇 |
1985年 | 6篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1982年 | 5篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1972年 | 1篇 |
排序方式: 共有743条查询结果,搜索用时 15 毫秒
1.
Masanori Hisaoka Takatoshi Aoki Hiromi Kouho Hirofumi Chosa Hiroshi Hashimoto 《Skeletal radiology》1997,26(3):191-194
The case of a 49-year-old man with Maffucci’s syndrome, who developed multiple spindle cell hemangioendotheliomas, is presented.
The case provides support for recent reports suggesting an association between this peculiar vascular lesion and skeletal
enchondromatosis. 相似文献
2.
James F. Meschia Edward Junkins Karen J. Hofman 《American journal of medical genetics. Part A》1992,44(5):664-667
Epidermal nevi are typically congenital but rarely familial. We report on a family in which 3 relatives have systematized epidermal nevi. The propositus also has evidence of a hemangioma and a hemangioendothelioma. Peripheral blood and skin fibroblast karyotypes of the propositus did not show evidence of mosaicism. Epidermal nevi have been associated with nondermatologic pathology, involving the nervous, vascular, and skeletal systems in sporadic cases. This report demonstrates that nondermatologic pathology can be also be associated with systematized epidermal nevi in a familial setting. The apparent skipping of generations may be explained by autosomal dominant inheritance with decreased penetrance. © 1992 Wiley-Liss, Inc. 相似文献
3.
Summary Six cases of epithelioid sarcoma were studied by conventional light microscopy and immunohistochemistry. The six cases account for 1.4% of the 417 cases of soft tissue sarcoma collected at the Paediatric Tumor Registry, Kiel. The average age of the five male and one female patient was 10.8 years (median: 13 years). Particular clinical findings included the location of the tumours; three were found in the pelvis, two in the head and neck, and one in the hand. Four patients are living without disease, and one patient died of disease three years after diagnosis.Histologically, four of the six tumours revealed multinucleated giant cells. Immunohistochemically using a panel of mono- and polyclonal antibodies all cases stained positively for vimentin, cytokeratin, epithelial membrane antigen (EMA), and human milk fat globulin (HMFG-2). Five cases were positive for neuron specific enolase (NSE), and three stained positively for protein S-100. A positive reaction for alpha-1-antichymotrypsin was noted in two cases. These immunohistochemical findings attest to the multidirectional differentiating capabilities of epithelioid sarcoma and support the concept of derivation from a multipotent mesenchymal stem cell.This study was supported in part by a grant from the Bundesminister für Arbeit und Sozialordnung and the Deutsche Forschungsgemeinschaft (Schm 613/1-1) 相似文献
4.
Ken-ichi Sasaki Yasuo Kokai Shin-ichi Atsumi Hirotoshi Tobioka Norimasa Sawada Koichi Hirata Michio Mori 《Medical Electron Microscopy》1998,31(2):61-67
Epithelioid disorganization is a hallmark of gastrointestinal cancers and is believed to be associated with malignant phenotypes such as invasiveness and the potentiality for metastasis. Although tight junctions (TJs) are known to be crucial for the maintenance of polarized organization of the gastrointestinal epithelium, changes in the TJ proteins in human cancers have not yet been fully elucidated. In this report, we investigated the expression and localization of three TJ proteins-barmotin (7H6 antigen), occludin, and ZO-1-in three phenotypically different human colon cancer cell lines exhibiting differnt grades of epithelioid organization. All three proteins were localized at the most apical part of the cell border corresponding to the site of TJs in T84 cells, in which epithelioid organization was well preserved. In contrast, in COLO320DM cells, which showed no epithelioid phenotypes, occludin was not detectable at either the protein or mRNA level, although barmotin and ZO-1 were present in the cytoplasm. In the third cell line, DLD-1, which showed an epithelioid phenotype intermediate between T84 and COLO320DM, aberrant expression of occludin was found in the basolateral cell membrane. On the other hand, barmotin was present in the cytoplasm, whereas ZO-1 was localized at the cell border. These observations showed that changes in the expression of TJ proteins occur in close correlation with epithelioid disorganization in human colon cancers. 相似文献
5.
Hisayuki Hiraiwa Minoru Hamazaki Satoru Tsuruta Hiroyoshi Hattori Jun-Ichi Mimaya Shirou Hasegawa Sumio Kohno Katsuhiko Aoki 《Pediatrics international》1998,40(6):604-607
Infantile hemangioendothelioma of the thymus is a rare disease. We describe a patient who developed a large anterior mediastinal mass, severe thrombocytopenia and massive pleural effusion at 1 month of age. Glucocorticosteroid and irradiation therapy had no effect on either the tumor size or clinical symptoms and the tumor was resected subtotally. Three months after the subtotal resection, the remaining tumor had almost disappeared and the symptoms had resolved. The patient has now been well for 1 year after surgery without evidence of recurrence. The tumor tissue was characterized by prominent vascular endothelial proliferation intermixed with a normal thymic structure, producing a picture consistent with that of an infantile hemangioendothelioma in the thymus, lmmunohistochemically, the tumor cells showed positive staining for vimentin, factor VIII and CD34. The DNA stemline and proliferative activity were examined by flow cytometry, which revealed a diploid stemline with a low growth fraction. DNA content and cell cycle analyses of the tumor tissue may be useful for predicting the biological behavior of the tumor. 相似文献
6.
The malignant vascular tumors of bone represent an uncommon diverse group of tumors with widely variable clinical and radiographic
presentations. Although the radiographic imaging features of the lytic osseous lesions typically seen with this group of tumors
are relatively nonspecific, the propensity to develop multifocal disease in an anatomic region is a feature that can be helpful
in suggesting the diagnosis of a vascular tumor. The differential diagnosis varies according to the age of the patient and
presence of solitary or multifocal disease. The histologic features are variable and range from tumors with vasoformative
features to those that mimic mesenchymal neoplasm or metastatic carcinoma. Familiarity with the radiographic and pathologic
spectrum of disease is essential for making an accurate diagnosis in this diverse group of neoplasms. This paper will provide
a review of the nomenclature for the malignant vascular tumors of bone and discuss the radiographic and pathologic differential
diagnosis.
Received: 17 December 1999 Revision requested: 8 February 2000 Revision received: 19 May 2000 Accepted: 9 June 2000 相似文献
7.
WANG Li-feng LIU Ming ZHU Hong HAN Wei HU Cheng-yi QI Ji-ping MEI Huan-lin GE Re-le ZHOU Min 《中华医学杂志(英文版)》2006,119(11):966-968
Primary cardiac hemangioendothelioma is extremely rare.1-3 Up to now less than twenty cases have been reported in English literature, the data about this kind of cardiac tumors are scanty. In this report, a case of a huge hemangio-endothelioma that arose from the right atrium and was successfully resected is presented. 相似文献
8.
9.
Lauren N. Stuart Jerad M. Gardner Scott R. Lauer David K. Monson Douglas C. Parker Mark A. Edgar 《Journal of cutaneous pathology》2013,40(10):909-913
Epithelioid sarcoma‐like (pseudomyogenic) hemangioendothelioma (ESHE) represents a rare soft tissue and bone tumor that typically presents as nodule(s) in the distal extremities of young adults. The nodules traverse several tissue planes simultaneously and can involve the dermis, subcutis, skeletal muscle and bone. ESHE shares clinical and microscopic features with epithelioid sarcoma (ES), and, accordingly, is commonly misdiagnosed as ES. However, unlike ES, which has a poor prognosis, ESHE commonly follows an indolent course. Herein, we report a case of ESHE diagnosed by skin biopsy that clinically mimicked a dermatofibroma. We also provide clinical photographs of the lesions in various stages of development, representing information that has not been previously published, to our knowledge. 相似文献
10.
《Seminars in diagnostic pathology》2017,34(2):183-191
A tumor composed of large eosinophilic cells in the liver raises concern for hepatocellular carcinoma, which is typically composed of such cells. However, there are other tumors, both primary and metastatic, that may be composed predominantly of large epithelioid cells. Distinction of these tumors from hepatocellular carcinoma and from each other is of obvious importance for patient management. Similarly, a clear cell tumor anywhere in the body triggers suspicion for renal cell carcinoma. However, other tumors, including hepatocellular carcinoma can rarely be composed entirely of cell cells and the distinction of these from one another, and of primary from metastatic disease is vital. As with the latter, accurate diagnosis is essential for patient management. Using illustrative examples, this article discusses differential diagnosis of liver tumors comprised predominantly of epithelioid cells or clear cells. 相似文献