全文获取类型
收费全文 | 32169篇 |
免费 | 1805篇 |
国内免费 | 741篇 |
专业分类
耳鼻咽喉 | 125篇 |
儿科学 | 736篇 |
妇产科学 | 280篇 |
基础医学 | 3391篇 |
口腔科学 | 349篇 |
临床医学 | 4719篇 |
内科学 | 7664篇 |
皮肤病学 | 148篇 |
神经病学 | 1613篇 |
特种医学 | 1295篇 |
外科学 | 3536篇 |
综合类 | 3904篇 |
现状与发展 | 2篇 |
一般理论 | 1篇 |
预防医学 | 2323篇 |
眼科学 | 286篇 |
药学 | 2818篇 |
10篇 | |
中国医学 | 563篇 |
肿瘤学 | 952篇 |
出版年
2023年 | 426篇 |
2022年 | 813篇 |
2021年 | 1218篇 |
2020年 | 1061篇 |
2019年 | 1208篇 |
2018年 | 1210篇 |
2017年 | 1058篇 |
2016年 | 995篇 |
2015年 | 1157篇 |
2014年 | 2172篇 |
2013年 | 2396篇 |
2012年 | 1561篇 |
2011年 | 1923篇 |
2010年 | 1534篇 |
2009年 | 1607篇 |
2008年 | 1682篇 |
2007年 | 1527篇 |
2006年 | 1399篇 |
2005年 | 1151篇 |
2004年 | 963篇 |
2003年 | 839篇 |
2002年 | 705篇 |
2001年 | 573篇 |
2000年 | 508篇 |
1999年 | 432篇 |
1998年 | 359篇 |
1997年 | 366篇 |
1996年 | 302篇 |
1995年 | 296篇 |
1994年 | 275篇 |
1993年 | 258篇 |
1992年 | 235篇 |
1991年 | 217篇 |
1990年 | 196篇 |
1989年 | 181篇 |
1988年 | 184篇 |
1987年 | 152篇 |
1986年 | 117篇 |
1985年 | 153篇 |
1984年 | 195篇 |
1983年 | 114篇 |
1982年 | 123篇 |
1981年 | 115篇 |
1980年 | 121篇 |
1979年 | 88篇 |
1978年 | 74篇 |
1977年 | 81篇 |
1976年 | 85篇 |
1975年 | 76篇 |
1973年 | 62篇 |
排序方式: 共有10000条查询结果,搜索用时 281 毫秒
1.
A 25-year-old, emaciated man without medical treatment was found to have died suddenly at home by his mother. At autopsy, there were no injuries to his body, but significant circulatory insufficiency was observed. Electron microscopy revealed abnormal mitochondria in cells of the cardiac conduction system. The conduction system was filled with mitochondrial size abnormalities and mitochondrial cristae abnormalities. No notable abnormal findings were observed in other organs. Genetic examination of the blood revealed the mitochondrial pathogenetic variant m.3243A>G. Epileptic seizures, diabetic ketoacidosis, and hyperosmolar hyperglycemic state were unlikely to be the cause of sudden death. The cause of death was diagnosed as arrhythmia possibly induced by the failure of the cardiac conduction system due to mitochondrial disease. This is a rare case of sudden death caused by an accumulation of abnormal mitochondria in the cardiac conduction system. 相似文献
2.
3.
The purpose of this study is to show a very rare complication of acute cocaine poisoning, namely heart rupture. In the present case report, acute cocaine intoxication caused massive myocardial infarction, resulting in heart rupture and cardiac tamponade. A crime scene investigation found a dead body on the street in a drug dealing district. Examination of the body showed no external injuries. A thorough autopsy was performed showing massive cardiac tamponade with 510 ml of blood within the pericardium and full-thickness tissue lesion at the posterior wall of the left ventricle of 3.5 × 3 cm. Histological examination in hematoxylin and eosin was performed and confirmed the interruption of the posterior wall of the left ventricle with the presence of blood. In fact, although the correlation between cocaine and myocardial damage is well established, the relationship between heart rupture and acute cocaine intoxication is an extremely rare event. Moreover, since there are, to date, few reports of similar deaths, our report provides useful information regarding sudden death in a cocaine abuser. It is, therefore, of crucial importance to report this case to the scientific community. 相似文献
4.
Ludefu Su Yu Liu Yanhong Tang Mingmin Zhou Liang Xiong Congxin Huang 《International journal of clinical and experimental pathology》2021,14(4):408
Background and objective: Myocardial infarction (MI) is a common critical disease of the cardiovascular system. The process of MI is often accompanied by the excessive activation of cardiac sympathetic nerves, which leads to arrhythmia. Resiniferatoxin (RTX) is a transient receptor potential vanilloid 1 (TRPV1), involved in the cardiac sympathetic afferent reflex. However, whether RTX can reduce the occurrence of arrhythmia and exert a cardioprotective effect by inhibiting the sympathetic reflex during MI is still unknown. Methods: The left anterior descending artery of cardiac was clamped to construct a model of MI. RTX (50 μg/ml) was used by epicardial application in MI rats. Ventricular electrophysiologic properties were continuously monitored by a body surface ECG. Yrosine hydroxylase (TH) and growth associated protein 43 (GAP43) were detected by Immunofluorescence staining. Connexin43 and transforming growth factor beta receptor 1 (TGF-β1) were detected by western blot. Norepinephrine (NE) and BNP levels in blood and tissue were determined by ELISA. Cardiac function was assessed by echocardiography. Results: The ERP, APD90, QRS, QT and the Tend-Tpeak intervals in MI rats were all prolonged, but decreased after RTX treatment (n = 3, P<0.05). In contrast, the RR interval was shortened in the MI group, but prolonged in the MI+RTX group (n = 3, P<0.05). RTX treatment significantly reduced ventricular arrhythmias after MI. TH- and GAP43-positive nerve densities and TGF-β1, and cx-43 protein expression were up-regulated in the MI group compared to the sham group, and they were decreased in the MI+RTX group compared to the MI group (n = 3, P<0.05). RTX can decrease serum and tissue NE and BNP levels (n = 3, P<0.05). RTX pretreatment significantly decreased heart rate, HW/BW ratio and LVIDS, and increased LVEF andLVFS values (n = 3, P<0.05). Conclusion: RTX improved cardiac dysfunction, ventricular electrophysiologic properties, and sympathetic nerve remodeling in rats with MI by inhibiting the excessive cardiac sympathetic drive. 相似文献
5.
6.
《The Medical clinics of North America》2022,106(3):545-555
7.
《Diagnostic Histopathology》2022,28(11):493-500
After decades of relative stagnation lung cancer is emerging as a disease type where rapid progress is being made in diagnosis and therapy, as well as in our understanding of disease biology. Much of this progress is of immediate impact to diagnosticians, and more is likely to affect diagnostic practice in the near future. In this review we seek to briefly summarize several key areas of active research of immediate or probable imminent value to trainee and consultant pulmonary pathologists alike. We cover some major changes in tumour classification, grading, and patient stratification, as well as considering the state of the art in machine-assisted interpretation of lung cancer histology, and the use of genetically modified lung cancer models. 相似文献
8.
9.
10.
Elizabeth D. Krebs Robert B. Hawkins J. Hunter Mehaffey Clifford E. Fonner Alan M. Speir Mohammed A. Quader Jeffrey B. Rich Leora T. Yarboro Nicholas R. Teman Gorav Ailawadi 《The Journal of thoracic and cardiovascular surgery》2019,157(4):1533-1542.e2