全文获取类型
收费全文 | 4518篇 |
免费 | 331篇 |
国内免费 | 104篇 |
专业分类
耳鼻咽喉 | 475篇 |
儿科学 | 20篇 |
妇产科学 | 77篇 |
基础医学 | 375篇 |
口腔科学 | 611篇 |
临床医学 | 472篇 |
内科学 | 203篇 |
皮肤病学 | 33篇 |
神经病学 | 44篇 |
特种医学 | 216篇 |
外科学 | 493篇 |
综合类 | 866篇 |
预防医学 | 188篇 |
眼科学 | 59篇 |
药学 | 297篇 |
3篇 | |
中国医学 | 125篇 |
肿瘤学 | 396篇 |
出版年
2024年 | 2篇 |
2023年 | 44篇 |
2022年 | 118篇 |
2021年 | 167篇 |
2020年 | 149篇 |
2019年 | 138篇 |
2018年 | 134篇 |
2017年 | 138篇 |
2016年 | 151篇 |
2015年 | 149篇 |
2014年 | 296篇 |
2013年 | 269篇 |
2012年 | 280篇 |
2011年 | 288篇 |
2010年 | 263篇 |
2009年 | 245篇 |
2008年 | 224篇 |
2007年 | 259篇 |
2006年 | 253篇 |
2005年 | 203篇 |
2004年 | 167篇 |
2003年 | 141篇 |
2002年 | 116篇 |
2001年 | 104篇 |
2000年 | 104篇 |
1999年 | 78篇 |
1998年 | 68篇 |
1997年 | 61篇 |
1996年 | 52篇 |
1995年 | 35篇 |
1994年 | 48篇 |
1993年 | 31篇 |
1992年 | 30篇 |
1991年 | 17篇 |
1990年 | 13篇 |
1989年 | 15篇 |
1988年 | 15篇 |
1987年 | 17篇 |
1986年 | 8篇 |
1985年 | 19篇 |
1984年 | 7篇 |
1983年 | 6篇 |
1982年 | 4篇 |
1981年 | 7篇 |
1980年 | 7篇 |
1979年 | 5篇 |
1978年 | 3篇 |
1976年 | 2篇 |
1973年 | 2篇 |
1969年 | 1篇 |
排序方式: 共有4953条查询结果,搜索用时 15 毫秒
1.
《The British journal of oral & maxillofacial surgery》2022,60(7):890-895
Patients undergoing sentinel node biopsy (SLNB) for early oral squamous cell carcinoma (OSCC) who harbour occult metastases (pN+ve) may be at greater risk of mortality due to prolonged overall treatment times than those identified as pN+ve on elective neck dissection (ELND). A retrospective comparative survival analysis was therefore undertaken to test this hypothesis. Patients were identified from the South Glasgow multidisciplinary team (MDT) database. Group 1 comprised 38 patients identified as pN+ve, or who were false negative, on sentinel lymph node biopsy (SLNB). Group 2 comprised 146 patients staged pN+ve on ELND. The groups were compared with the Kaplan Meier method and Cox proportional hazards model. In addition, a matched-pair analysis was performed. A unique and specifically designed algorithm was deployed to optimise the pairings. No difference in disease-specific or overall survival was found between the groups. Patients undergoing SLNB as the initial neck staging modality in early OSCC and are identified as pN+ve do not appear to be at a survival disadvantage compared with those staged with ELND. 相似文献
2.
ObjectivesMap regional lymph node metastases for lateralized oral cavity squamous cell carcinoma (OCSCC) and evaluate factors associated with regional metastases and recurrence.Materials and methodsRetrospective cohort study of 715 patients with lateralized OCSCC surgically treated in 1997–2011. Analysis was performed using log-rank, Kaplan-Meier, and multivariable logistic and Cox regression.ResultsRegional metastases were identified in ipsilateral levels IIA (24%), IB (18%), III (13%), V (9%), IV (7%), IA (2%) and IIB (1%) and the contralateral neck (3%). Lymphovascular invasion (LVI) (Hazard Ratio [HR] 2.2, 95% Confidence Interval [CI] 1.2–3.9) and T category (T3 vs. T1: HR 4.1, 95% CI 1.9–9.3; T4 vs. T1: HR 2.3, 95% CI 1.2–4.3) were associated with regional metastases. Most (71%) isolated regional metastatic recurrences were in undissected levels of the neck, including 58% in levels IV and V. Tumors of the hard palate (HR 4.3, 95% CI 1.2–16.1), upper alveolus (HR 3.2, 95% CI 1.0–4.7) or with LVI (HR 2.0, 95% CI 1.0–3.9) were associated with isolated regional recurrence. For upper alveolar/hard palate tumors, depth of invasion (DOI) ≥4 mm (P = .003) and LVI (P = .04) were associated with regional metastases.ConclusionsFor lateralized OCSCC, elective neck dissection of level IIB or the contralateral neck may rarely be needed, but additional surgical or radiation treatment of levels IV and V may be considered based on patient risk factors, including T category 3–4 or LVI. For upper alveolar/hard palate tumors, DOI ≥4 mm is an appropriate threshold for elective neck dissection. 相似文献
3.
4.
《European journal of surgical oncology》2019,45(11):2151-2158
IntroductionLymph node yield (LNY) in neck dissection has been identified as a prognostic factor in oral cavity cancer. The purpose of this study was to investigate the impact of additional use of optical imaging on LNY in therapeutic ND in oral cancer.MethodsConsecutive patients with oral squamous cell carcinoma with clinical neck metastasis planned for primary tumor resection were randomized to conventional neck dissection or near-infrared fluorescence (NIRF)-guided neck dissection, respectively. In the intervention group, patients were injected with ICG-Nanocoll prior to surgery. Intraoperatively, an optical hand-held camera system was used for lymph node identification. Also, NIRF imaging of the neck specimen was performed, and optical signals were pinned with needle markings to guide the pathological examination. The endpoint of the study was LNY per neck side in levels Ib-III.Results31 patients were included with 18 neck sides in the control group and 18 neck sides in the intervention group for evaluation. During NIRF-guided ND, individual lymph nodes could be identified by a bright fluorescent signal and individual tumor-related drainage patterns could be observed in the neck. The LNY in the intervention group was significantly higher compared to the control group (p = 0.032) with a mean of 24 LN (range: 12–33 LN in levels Ib-III compared to 18 LN (range: 10–36 LN) in the control group, respectively.ConclusionsNIRF-guided ND significantly improved the nodal yield compared to the control group. Intraoperative real-time optical imaging enabled direct visualization of tumor-related drainage patterns within the neck lymphatics. 相似文献
5.
6.
Acoustic rhinometry was performed in 35 normal nose-breathing children between 3 and 6 years. The average cross-sectional areas at the nasal valve, at the anterior end of the turbinates, and in the nasopharynx were 0.34±0.06 cm2, 0.35±0.08 cm2 and 1.37±0.48 cm2 respectively. The average minimal cross-sectional area was 0.29±0.06 cm2. The minimal cross-sectional area was located at the nasal valve in 14 and at the anterior end of nasal tubinates in 21 of the 35 children. As would be expected, the cross-sectional areas at different sites of the nasal cavity increased with increasing age of the children. But, whereas the minimal cross-sectional area increased by 0.024 cm2 per year, the nasopharyngeal cross-sectional area increased by 0.20 cm2 per year. No significant differences were found between boys and girls. Measurements of the posterior nasal and nasopharyngeal cross-sectional areas were unreliable, whenever the minimal cross-sectional area was less than 0.2 cm2. Furthermore, assessment of the nasopharynx may be difficult because of involuntary movements of the soft palate. 相似文献
7.
目的 研究透明质酸钠玻璃体腔内充填对严重开放性眼球损伤预后的影响。方法 在严重开放性眼球损伤一期手术缝合后玻璃体腔内充填透明质酸钠至眼压Tn。结果 用透明质酸钠在玻璃体腔内充填,眼球萎缩的发生率(6.67%)明显低于用BSS液充填的发生率(70.58%)。结论 透明质酸钠玻璃体腔内充填在严重开放性眼球损伤治疗中的应用对眼球外形维持和视功能恢复有重要作用。 相似文献
8.
真皮-脂肪颗粒混合液注射移植修复面部凹陷性组织缺损 总被引:2,自引:0,他引:2
目的探索一种新的面部凹陷性组织缺损的修复方法。方法将真皮颗粒和脂肪颗粒混合制成真皮-脂肪颗粒混合液,用2mm脂肪抽吸针注射移植修复面部凹陷性组织缺损。结果本组18例,17例1次填充成功,仅1例因缺损面积过大而补充填充1次,全部病例伤口均Ⅰ期愈合,无感染,外形明显改善。结论真皮-脂肪颗粒混合移植修复面部凹陷性组织缺损,手术简单易行,术后吸收少,效果较好,值得推广。 相似文献
9.
目的探讨低能量氦-氖激先局部加穴位照射对肺结核空洞的治疗作用机理。方法91例初治Ⅲ型肺结核(肺部有空洞)随机分为实验组46例,对照组45例,均用6个月短程化疗方案.实验组加氦-氖激光局部、双肺俞穴位照射治疗3个疗程,观察空洞闭合及痰菌阴转情况,以X2检验分析组间治疗结果的差异.结果实验组治疗2、3个月空洞闭合分别为58.3%、70.8%;对照组为354%、479%,二者均有显著性差异(P<0.05),实验组痰菌阴转、肺部病灶吸收、临床症状改善均高于对照组。结论低能量氦-氖激光局部加双肺俞穴位照射,可加速肺结核空洞的闭合及临床症状的改善 相似文献
10.
本文报告胰岛细胞脑内移植治疗I型糖尿病共3例,分别经过3个月、4个月、6个月的临床观察,其临床症状明显改善或消失,空腹血糖由移植前平均12.38mmol/L下降至7.77mmol/L;3例患者普通胰岛素用量平均每日62.3~u,移植后第21~30天均完全停用胰岛素,其中1例已持续撤离胰岛素治疗达5个月。观察结果提示:胰岛移植物在患者的脑内成活,并具有良好的内分泌功能。 相似文献