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排序方式: 共有128条查询结果,搜索用时 15 毫秒
1.
Mariko Sakata Masaji Utsu Kazuo Maeda 《The Ultrasound Review of Obstetrics & Gynecology》2006,6(3):135-140
Objectives. Twin to twin transfusion syndrome (TTTS) is one of the most important problems for perinatal management of monochorionic twins. Since TTTS is deeply related to the prognoses of both fetuses, fetal circulation and placental blood flow of monochorionic twins were studied with the purpose of clarifying characteristic features.
Methods. The patterns and numbers of vascular anastomoses were checked on the placental surface, arterio-arterial (A-A) anastomosed vessels by ultrasound, and circulatory changes were studied with relation to uterine contraction.
Results. The high risk of monochorionic twin pregnancies was largely related to the patterns of vascular anatomy of the placenta and numbers of anastomosed vessels. The first placental vascular connection detected in vivo was the A-A anastomosis characterized by the bidirectional flow waveform in pulsed Doppler velocimetry.
Conclusion. TTTS is related to anastomosed vessels on the surface of placenta. To manage and prevent TTTS, fetal circulation and placental blood flow should be carefully observed. 相似文献
Methods. The patterns and numbers of vascular anastomoses were checked on the placental surface, arterio-arterial (A-A) anastomosed vessels by ultrasound, and circulatory changes were studied with relation to uterine contraction.
Results. The high risk of monochorionic twin pregnancies was largely related to the patterns of vascular anatomy of the placenta and numbers of anastomosed vessels. The first placental vascular connection detected in vivo was the A-A anastomosis characterized by the bidirectional flow waveform in pulsed Doppler velocimetry.
Conclusion. TTTS is related to anastomosed vessels on the surface of placenta. To manage and prevent TTTS, fetal circulation and placental blood flow should be carefully observed. 相似文献
2.
目的:探讨双胎贫血多血质序列症(TAPS)临床特点、治疗及近期预后,以提高临床医生对本病的认识。方法:对广州医科大学附属第三医院胎儿医学中心2013年8月至2016年3月诊断为TAPS的8例病例的临床超声检查、处理及胎儿分娩后新生儿的临床资料进行归纳研究。结果:8例TAPS病例中,7例自然发病病例平均发病孕周24.38周,分期为1期2例,分期为3期5例;1例继发于激光手术后3周为3期病例。4例采取保守期待治疗,4例采取选择性射频消融减胎治疗。保守期待治疗病例中有2例已分娩,受血胎出生平均体质量1732.50 g,平均血红蛋白(Hb)224.00 g/L,平均网织红细胞(Ret)计数0.0563;供血胎儿平均出生体质量1560.00 g,平均Hb 84 g/L,平均Ret计数0.1721。选择性减胎病例全部分娩,新生儿出生平均体质量2227.50 g。8例中除1例失访,2例仍在妊娠,其余5例生长发育及神经系统发育均位于同胎龄正常水平。结论:TAPS复杂双胎的产前超声、产后临床表现及新生儿预后差异较大,故在临床处理中应给以重视。 相似文献
3.
Ierullo AM Papageorghiou AT Bhide A Fratelli N Thilaganathan B 《BJOG : an international journal of obstetrics and gynaecology》2007,114(6):689-693
Objective To assess the safety and efficacy of a modified fetoscopic laser ablation technique for the management of severe twin–twin transfusion syndrome (TTTS) in a large series of pregnancies.
Design Prospective cohort study.
Setting Tertiary referral fetal medicine unit.
Population Women with pregnancies complicated by severe TTTS (Quintero stage III or IV), before 26 weeks of gestation.
Methods Fetoscopic laser ablation of placental anastomoses was performed. The sonoendoscopic approach was used to identify the placental vascular equator and to photocoagulate crossing vessels.
Main outcome measures Overall survival, fetal and perinatal mortalities, gestational age at delivery, birthweight, operating time and recurrence of TTTS.
Results A total of 77 women underwent the procedure. The mean gestational age at treatment was 20 (range 16–26) weeks. On average, four vessels were ablated during each procedure, with a mean operative time of 15 (range 5–25) minutes. None of the women required a repeat fetoscopic laser treatment for recurrence of the TTTS. There was at least one survivor in 74% (57/77) of pregnancies, and the overall survival rate was 57% (88/154).
Conclusions Fetoscopic laser ablation is a safe and effective form of treatment in the management of severe TTTS. The technique of identifying the common villous district of the placenta by ultrasound and photocoagulating any vessels crossing the vascular equator appears to be an acceptable alternative to both the nonselective and highly selective methods described so far. This approach is associated with a short operating time, low likelihood of TTTS recurrence or fetal anaemia and with survival results that are equivalent to previously reported techniques. 相似文献
Design Prospective cohort study.
Setting Tertiary referral fetal medicine unit.
Population Women with pregnancies complicated by severe TTTS (Quintero stage III or IV), before 26 weeks of gestation.
Methods Fetoscopic laser ablation of placental anastomoses was performed. The sonoendoscopic approach was used to identify the placental vascular equator and to photocoagulate crossing vessels.
Main outcome measures Overall survival, fetal and perinatal mortalities, gestational age at delivery, birthweight, operating time and recurrence of TTTS.
Results A total of 77 women underwent the procedure. The mean gestational age at treatment was 20 (range 16–26) weeks. On average, four vessels were ablated during each procedure, with a mean operative time of 15 (range 5–25) minutes. None of the women required a repeat fetoscopic laser treatment for recurrence of the TTTS. There was at least one survivor in 74% (57/77) of pregnancies, and the overall survival rate was 57% (88/154).
Conclusions Fetoscopic laser ablation is a safe and effective form of treatment in the management of severe TTTS. The technique of identifying the common villous district of the placenta by ultrasound and photocoagulating any vessels crossing the vascular equator appears to be an acceptable alternative to both the nonselective and highly selective methods described so far. This approach is associated with a short operating time, low likelihood of TTTS recurrence or fetal anaemia and with survival results that are equivalent to previously reported techniques. 相似文献
4.
Different outcomes of vertical transmission of hepatitis C virus in a twin pregnancy 总被引:4,自引:0,他引:4
Inui A Fujisawa T Sogo T Komatsu H Isozaki A Sekine I 《Journal of gastroenterology and hepatology》2002,17(5):617-619
The risk of vertical transmission of hepatitis C virus (HCV) from mother to infant has been well documented, but the exact mode of transmission is still unclear. In a set of monochorionic diamniotic monozygous twins, only the second baby was infected with HCV from the mother who was positive for serum HCV-RNA. The babies had an uncomplicated vaginal delivery 3 min apart and they were both bottle fed from the outset. The second baby developed clinical hepatitis that persisted to 30 months follow up. The intrauterine environment should have been identical for these twins, and therefore, the maternal HCV factors, including viral load are not the sole determining factors for mother-to-infant transmission of HCV. 相似文献
5.
Michelle Loh Anju Bhatia Kai Lit Tan Edwin Thia George Seow Heong Yeo 《Singapore medical journal》2020,61(10):523
INTRODUCTIONFetoscopic laser photocoagulation (FLP), a treatment option for twin-to-twin transfusion syndrome (TTTS) in monochorionic twin pregnancies, is currently the treatment of choice at our centre. We previously reported on our experience of FLP from June 2011 to March 2014. This paper audits our fetal surgery performance since then.METHODS15 consecutive patients who underwent FLP for Stage II–III TTTS before 26 weeks of gestation from June 2011 to January 2017 were retrospectively reviewed, consisting of five cases from our initial experience and ten subsequent cases. Perioperative, perinatal and neonatal outcomes were analysed.RESULTSOf 15 pregnancies, 10 (66.7%) and 5 (33.3%) were for Stage II and III TTTS respectively, with FLP performed at an earlier Quintero stage in the later cohort. Overall mean gestational ages at presentation, laser and delivery were comparable between the cohorts at 19.7 (15.4–24.3) weeks, 20.3 (16.3–25.0) weeks and 31.2 (27.6–37.0) weeks, respectively. 2 (13.3%) cases had intra-amniotic bleeding and 1 (6.7%) had iatrogenic septostomy. 1 (6.7%) case had persistent TTTS requiring repeat FLP, and another (6.7%) had preterm premature rupture of membranes at seven weeks post procedure. The overall perinatal survival rate was 21 (75.0%) out of 28 infants. One mother underwent termination of pregnancy for social reasons at 1.4 weeks post procedure. Double survival occurred in 8 (57.1%) out of 14 pregnancies, while 13 (92.9%) had at least one survivor.CONCLUSIONFLP requires a highly specialised team and tertiary neonatal facility. Continual training improves maternal and perinatal outcomes, ensuring comparable standards with international centres. 相似文献
6.
Fiona Bamforth Geoffrey Machin Micheil Innes 《American journal of medical genetics. Part A》1996,61(3):209-215
Patterns of X-chromosome inactivation in chorion, amnion, and cord from 79 pairs of twins were examined. Seven sets of triplets were included in the analysis, both as twin pairs and triplets. Twins were stratified as dizygotic (DZ), monozygotic (MZ), monochorionic, and dichorionic and were selected for birth weight discordance, discordance for congenital anomalies, twin-twin transfusion syndrome, and various patterns of vascular anastomosis. X-inactivation was predominantly symmetric. Chorion was the most likely tissue to show asymmetric X-inactivation and was found most frequently in MZ dichorionic twins. There was no correlation of X-inactivation pattern with the selected clinical criteria. This study does not confirm that asymmetric X-inactivation in embryonic tissues is a common phenomenon in female twins, including monozygotic twins. © 1996 Wiley-Liss, Inc. 相似文献
7.
Ying Nie Xiaoyong Qiao Sicong Li Zhuo Pan Jing Zhang Liangzhi Xu 《The Journal of international medical research》2022,50(2)
Monozygotic triplet pregnancies are very rare in assisted reproductive technology, and the relationship between monozygotic multiple pregnancies and several assisted reproductive techniques, including blastocyst transfer, remains unclear. Here, the case of a 28-year-old female patient with dichorionic quadruplet pregnancy following intracytoplasmic sperm injection and transfer of two day-3 fresh embryos, without assisted hatching, is reported. At 7 weeks following embryo transfer, the dichorionic quadruplet pregnancy, comprising monozygotic monochorionic triamniotic (MCTA) triplets plus a singleton, was detected by a transabdominal ultrasound scan. After counselling, the patient underwent selective reduction of the MCTA triplet pregnancy at 7 weeks after embryo transfer. The remaining singleton pregnancy was uneventful, resulting in a live birth at 38+ weeks. As the predictors of monozygotic multiple gestations remain poorly characterized, clinicians and patients should give great consideration to the risks associated with monozygotic multiple pregnancies, even if the patient has not undergone blastocyst transfer. 相似文献
8.
9.
Williams CA Wallace MR Drury KC Kipersztok S Edwards RK Williams RS Haller MJ Schatz DA Silverstein JH Gray BA Zori RT 《Human reproduction (Oxford, England)》2004,19(12):2816-2821
We report on dizygotic (DZ) twins, conceived by IVF and ICSI with assisted hatching, who each had a mixture of 46,XX and 46,XY cells in blood lymphocytes. The female twin had mild genitalia abnormalities but further study revealed anatomically normal reproductive anatomy. Chromosome and fluorescence in situ hybridization studies of buccal, skin and ovarian tissue were normal, as were buccal tissue DNA studies. Fetal ultrasound and fetal membrane pathology were consistent with a monochorionic, diamniotic placenta (MCDAP). These twins thus have blood chimerism but are not chimeric in the other tissues studied. The mechanism for the chimerism could be due to either placental vascular anastamoses (after the development of the haematoblast stem cells) or due to an admixture of trophoblast cells during early blastocyst development. Such trophoblast cell admixtures would be restricted to the extraembryonic tissues so that general physical development in the fetus is normal and without somatic cell chimerism. This case in combination with others previously reported suggests that in IVF conceptions, the prevalence of blood chimerism associated with twinning, and the occurrence of DZ twinning associated with MCDAP, may be higher than previously thought. 相似文献
10.
Prevalence of congenital heart defects in monochorionic/diamniotic twin gestations: a systematic literature review. 总被引:2,自引:0,他引:2
Mert Ozan Bahtiyar Antonette T Dulay Bevin P Weeks Alan H Friedman Joshua A Copel 《Journal of ultrasound in medicine》2007,26(11):1491-1498
OBJECTIVE: Congenital heart defects (CHDs) affect approximately 0.5% of all neonates. Recent literature points to a possible increase in the CHD prevalence among monochorionic/diamniotic (MC/DA) twin gestations. We hypothesized that MC/DA twin pregnancy is a risk factor for CHD. METHODS: A systematic review of all published English literature was conducted on MEDLINE (Ovid and PubMed) from January 2000 through April 2007 using the medical subject heading terms "congenital heart defect" and "monozygotic twins." Four observational studies were included in the final analysis. Published historical data were used for the population background risk of CHD. Relative risk (RR) estimates with 95% confidence intervals (CIs) were calculated by fixed and random effect models. RESULTS: We included a total of 40 fetuses with CHDs among 830 fetuses from MC/DA twin gestations. Compared with the population, CHDs were significantly more prevalent in MC/DA twins regardless of the presence of twin-twin transfusion syndrome (TTTS) (RR, 9.18; 95% CI, 5.51-15.29; P < .001). Monochorionic/diamniotic twin gestations affected by TTTS were more likely to be complicated by CHDs than those that did not have TTTS (RR, 2.78; 95% CI, 1.03-7.52; P = .04). Ventricular septal defects were the most frequent heart defects. Pulmonary stenosis and atrial septal defects were significantly more prevalent in pregnancies complicated with TTTS. CONCLUSIONS: Monochorionic/diamniotic twin gestation appears to be a risk factor for CHDs. Conditions that lead to abnormal placentation may also contribute to abnormal heart development, especially in MC/DA twin pregnancies complicated with TTTS. Fetal echocardiography may be considered for all MC/DA twin gestations because ventricular septal defects and pulmonary stenosis are the most common defects. 相似文献