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1.
《Surgical pathology clinics》2015,8(4):587-621
According to the current World Health Organization (WHO), renal cell carcinomas (RCCs) that primarily affect adults are classified into 8 major subtypes. Additional emerging entities in renal neoplasia have also been recently recognized and these are discussed in further detail by Mehra et al (Emerging Entities in Renal Neoplasia, Surgical Pathology Clinics, 2015, Volume 8, Issue 4). In most cases, the diagnosis of a RCC subtype can be based on morphologic criteria, but in some circumstances the use of ancillary studies can aid in the diagnosis. This review discusses the morphologic, genetic, and molecular findings in RCCs previously recognized by the WHO, and provides clues to distinction from each other and some of the newer subtypes of RCC. As prognosis and therapeutic options vary for the different subtypes of RCC, accurate pathologic distinction is critical for patient care. 相似文献
2.
Shoji Kubo Hiroaki Kinoshita Kazuhiro Hirohashi Takatsugu Yamamoto 《Journal of Hepato-Biliary-Pancreatic Surgery》1995,2(1):85-89
A case of cystadenocarcinoma of the liver is reported. The patient was a 73-year-old woman in whom a tumor was detected in
the lateral segment of the liver during a health examination. Ultrasonograms and computed tomograms showed a multilocular
cystic mass. Magnetic resonance imaging (MRI) showed a multilocular lowintensity mass, including a high-intensity portion
and a portal branch compressed by the tumor. MRI with gadolinium showed an enhanced cyst wall. The cystic part of the tumor
became smaller and the solid part became larger over a 1-month period, indicating that the tumor was malignant. Subsegmentectomy
(S3) was performed and cystadenocarcinoma with cystadenoma was diagnosed by histopathological examination. Identification of
changes in the appearance of a tumor should be helpful for the differential diagnosis of cystadenoma and cystadenocarcinoma. 相似文献
3.
4.
目的:比较研究直肠印戒细胞癌和粘液腺癌临床和病理学特点的差异。方法:回顾性地对比分折20例直肠印戒细胞癌和同期79例直肠粘液腺癌的临床和病理学特点。结果:直肠印戒细胞癌组的一年生存率65.0%,三年生存率30.0%,五年生存率5.0%。黏液腺癌组一年生存率84.8%,三年生存率58.2%,五年生存率38.0%。两在显微镜下黏液分布不同,肉眼所见大体标本相差甚远。结论:直肠印戒细胞癌较直肠粘液腺癌的诊断困难,恶性度高,预后差,临床上应对二区别对待,术中冰冻切片有助于提高病理诊断准确率,从而指导手术。 相似文献
5.
Tetsuo Ohta Takukazu Nagakawa Hiroshi Itoh Luis Fonseca Itsuo Miyazaki Tadashi Terada 《Journal of gastrointestinal cancer》1993,14(3):283-289
Summary We present a serous cystadenoma of the pancreas with focal malignant changes, and describe its characteristic histological
features. On gross examination, a tumor was present on the anterior surface of the body of the pancreas and measured approx
25×25⋻20, mm. Microscopically, most tumor cells showed the typical histological features of serous cystadenoma, characterized
by a microcystic architecture and glycogenrich cells with a uniform and bland appearance. However, in some areas, a tendency
to papillary structures with fibrovascular cores was noted. These papillary lesions were composed mainly of nonmucinous, glycogen-poor
epithelial cells, the nuclei of which showed a mild atypia. In addition, vascular and perivascular invasion was focally observed.
However, there was no clinical evidence of local or distant metastasis. From these findings, we diagnosed this lesion as a
serous cystadenoma of the pancreas with focal malignant changes rather than a serous cystadenocarcinoma of the pancreas. 相似文献
6.
A 35-year-old man complained of a painless enlargement of the right testis. Imaging diagnostic procedures demonstrated a multiloculated cystic tumor, 9 cm in maximal diameter, in the right testis with hydrocele. Orchidectomy specimen showed that the tumor was confined within the testis and separated from the epididymis. The locules of the tumor were lined by single-layered columnar epithelium, intermingled with MUC2 immunopositive goblet and chromogranin-A immunopositive neuroendocrine cells, exhibiting intestinal differentiation. No ciliated cell, teratomatous element or intratubular germ cell neoplasia were seen. Channels of rete testis were compressed peripherally by the tumor but there was no connection with the tumor locules. The tumor was diagnosed as mucinous cystadenoma of the testis. This seems to be the first published case of benign mucinous cystadenoma occurring within the testis. This intratesticular tumor with intestinal differentiation may represent a benign monodermal teratoma. 相似文献
7.
Michael Z. Gilcrease MD PhD Laura Schmidt PhD Berton Zbar MD Luan Truong MD Michael Rutledge MD Thomas M. Wheeler MD 《Human pathology》1995,26(12)
Papillary cystadenoma of the epididymis is an uncommon benign lesion that may occur sporadically or as a manifestation of von Hippel—Lindau (VHL) disease. Neither immunohistochemical studies nor molecular genetic analyses of the VHL gene have been reported previously for this lesion. The authors describe two cases of clear cell papillary cystadenoma of the epididymis, both of which were initially confused with metastatic renal cell carcinoma. Both lesions showed positive immunohistochemical staining for low and intermediate molecular weight keratins (Cam 5.2 and AE1/AE3), EMA, vimentin, α1-antitrypsin, and α1-antichymotrypsin. Each was negative for CEA. Because clear cell papillary cystadenoma is similar to renal cell carcinoma histologically, and because both occur as components of the von Hippel—Lindau disease complex, the authors analyzed both cases for the presence of mutations in the VHL gene. A somatic VHL gene mutation was detected in one of the two tumors by polymerase chain reaction followed by single-strand conformation polymorphism analysis. Direct sequencing revealed a cytosine to thymine transition at nucleotide 694, resulting in the replacement of an arginine with a stop codon after the sixth amino acid of exon 3. As the VHL gene is believed to function as a tumor suppressor gene, VHL gene mutations may play a role in the initiation of tumorigenesis in sporadic cystadenomas of the epididymis. 相似文献
8.
We present an extremely rare case of ovarian serous cystadenoma with mural nodules of rhabdomyoma. The patient, a 48-year-old woman, was admitted to our hospital with left lower abdominal pain and vaginal bleeding. A unilocular cystic tumor, measuring 13 x 10 x 10 cm, was found in her left ovary and was removed. The tumor contained clear serous fluid, approximately 600 mL, and 2 mural nodules, up to 7.5 x 5.5 x 4.5 cm. The internal cystic wall was thin for the most part and lined with ciliated cuboidal epithelium without any malignant feature. The mural part was composed of mainly more mature muscle fibers with easily discernible cross-striations, set in abundant myxoid to fibromyxoid stroma, similar to clinical and microscopic manifestations of genital rhabdomyomas reported in other sites. Because extracardiac rhabdomyoma has never been described occurring in the ovary, especially arising in serous cystadenoma, to our knowledge, this is the first case reported in the English literature. 相似文献
9.
Handra-Luca A Couvelard A Sauvanet A Fléjou JF Degott C 《Virchows Archiv : an international journal of pathology》2004,445(2):203-205
We report an unusual type of mucinous cystadenoma of the pancreas, characterised by a predominantly solid gross appearance due to the presence of an abundant ovarian-type stroma. The tumour, located in the body of the pancreas, was discovered after episodes of acute pancreatitis. It was composed of several mucus-secreting benign cysts placed within a highly cellular ovarian-type stroma, composed of undifferentiated spindle cells with mild atypia but without any increase of mitotic activity and with a low proliferative index. These cells expressed oestrogen and progesterone receptors, but they did not express CD34, CD117, p53 protein or bcl-2. Recognition of this peculiar mainly solid mucinous cystadenoma containing an abundant ovarian-type stroma is difficult. It is conceivable that the mesenchymal component described in our case could represent an early stage in the development of sarcoma in mucinous cystadenoma of the pancreas. 相似文献
10.
Michal M Skálová A Mukensnabl P 《Virchows Archiv : an international journal of pathology》2000,437(4):465-468
We describe a 45-year-old man who had a 2-year history of a slowly enlarging tumor in the left parotid gland. Histologically,
the tumor was a mucinous cystadenoma with focal apocrine differentiation, which revealed a widespread invasive micropapillary
adenocarcinoma component. A rim of lymphoid tissue surrounded the margins of the micropapillary carcinoma. The invasive micropapillary
adenocarcinoma component was morphologically identical with the invasive micropapillary carcinoma of the mammary gland. The
tumor is different from so-far recognized salivary gland tumor entities.
Received: 25 October 1999 / Accepted: 13 June 2000 相似文献