双炔失碳酯或丙睾配伍dl-15甲基PGF_(2α)抗早孕的临床比较

本文报告65例双炔失碳酯配伍d1-15甲基PGF_(2α)(以下简称PG)抗早孕结果并与33例丙睾配伍PG抗早孕结果进行比较。结果显示,双炔失碳酯组完全流产59例,占90%;不全流产3例,占5%;失败3例,占5%;总有效率95%。丙睾组完全流产27例,占82%;不全流产6例,占18%;总有效率100%。两组总有效率无显著差异;完全流产率无显著差异;但不全流产率有明显差异(P<0.05)。药流后点滴出血天数,双炔失碳酯组平均为8.1±5.0天;丙睾组平均为18.9±19.1天;两组有明显差别(P<0.05)。双炔失碳酯经阴道给药后无一例发生心、肝、肾功能变化。     

双炔失碳酯类似物的抗生育活性研究

本文报道八个双炔失碳酯类似物的小鼠抗早孕、抗着床试验结果,同时考查了生物活性与油水分布系数之间的关系,发现抗早孕活性与油水分布系数之间为线性相关。双炔失碳半琥珀酸酯的抗早孕效果优于已用于临床的双炔失碳丙酸酯。     

Effects of Mifepristone Compound on the Receptors of Estrogen and Progesterone in Early Pregnancy Deciduas

Mifeprlstone,a norethindrone, is the first synthetic effective steroid which canbind to the progesterone receptor with greater affinity than progesterone, but lacksthe agonistic effect. Its anti--progestin action results in the withdrawal of progesterone at cellular level to interrupt its biological action and can terminate early pregnancy['j. At present, the dose of mifepristone in combination with the analogue ofprostaglandin in terminating early pregnancy is 150 mg-- 200 mg and the complete…     

Effect of Mifepristone and Anordrin Compound on Levels of Estrogen and Progesterone Receptor mRNAs in Human Decidua of Early Pregnancy

Objective To provide the theoretical fundation for the further clinical application of mi fepristone and anordrin compound. Materials & Methods Ribonuclease protection assay was used for the detection and quantitation of estrogen and progesterone receptor mRNAs in human decidua from the termination of early pregnancy. Three groups, each of which had 6～8 cases, were studied. Results Compared to the normal control group, estrogen and progesterone receptor mRNAs increased significantly (P＜0.05) in the mifepristone group, whereas the changes in the group administrated mifepristone compound which contains anordrin were not obvious. Conclusions The result suggests that with the similar clinical effect, mifepristone compound has less side effect on the patients, thus being more suitable for the anti-ear ly pregnancy drug.     

Anordrin对人体子宫内膜超微结构的影响

本文报道了口服Anordrin一个周期的妇女子宫内膜腺体细胞和基质细胞超微结构的变化。结果指出,服药2—3天后两类细胞的线粒体都发生肿胀,这可能是抑制腺体细胞发育和基质细胞转化的重要原因。溶酶体的提早出现又表明Anordrin 有促使子宫内膜早衰的作用,这可能与黄体功能不足有关,另从Anordrin 对离体培养子宫内膜的作用看,也不能排除Anordrin 对细胞有直接作用。     

双炔失碳酯加强米非司酮终止早孕的临床观察

目的:观察双炔失碳酯加强米非司酮对人体抗早孕的作用,以期提高药物流产的成功率,减轻药物流产后出血时间长的副作用。方法: 143例研究对象使用随机数字表法分为对照组72例,常规药物流产;观察组71例,在常规药物流产基础上加用双炔失碳酯7. 5mg,间隔24h, 2次。观察分析两组对象孕囊排出时间、流产后阴道出血情况及尿hCG的变化。结果:与对照组相比,观察组孕囊排出时间及流产后出血时间均明显缩短(P<0. 01 ),药流后出血时间≤14天者明显增加(P<0. 01 ), >21天者明显减少(P<0. 01 ),流产后两周尿hCG阳性率明显降低(P<0. 05);观察组完全流产率高于对照组,但无统计学差异(P>0. 05)。结论:在常规流产药物的基础上加用小剂量双炔失碳酯可以加强米非司酮的抗早孕作用,缩短药物流产后出血时间,提高药物流产的安全性。     

双炔失碳酯经阴道给药的抗生育研究

双炔失碳酯为一种女用口服探亲避孕药。实验证明本品在动物经阴道给药具有显著的抗生育作用。其抗着床作用优于口服给药法。经阴道给药法方便易行,且无明显不良反应。本资料可为临床研究提供借鉴。     

双炔失碳酯注射剂抗小鼠早孕的研究

作者设计与筛选注射溶媒作成了双炔失碳酯注射剂。该注射剂急性毒性低、安全性好,置于95±2℃恒温振荡水浴中76小时和37℃恒温孵箱中放置3月,其外观及含量均无改变,经热解动力学参数测定其活化能为68.1kJ/mol,表明其稳定性好。双炔失碳酯剂量为3mg/kg的抗小鼠早孕试验结果表明,注射剂较口服53号抗孕片的抗早孕效果显著提高(P<0.01)。组织学观察,小鼠胚胎的蜕膜细胞及滋养层细胞均表现出不同程度的退化坏死。     

α—双炔失碳酯诱导人早幼粒白血病HL—60细胞分化

目的：研究α－双炔失碳酯对人早幼粒细胞白血病ＨＬ－６０细胞的分化诱导作用。方法 ：细胞生长用台盼蓝排染法；细胞分化根据细胞形态，酸性磷酸酶活性来决定；细胞周期变化用流式细胞光度术；细胞特异性抗原的表达用免疫细胞化学方法。     

反相HPLC测定“抗孕-53”差向异构体

本文介绍了“抗孕-53”差向异构体的反相HPLC测定方法。“抗孕-53”差向异构体中,α体的C_2炔基处于e键,β体的C_2炔基处于α键,利用两者极性的微小差异,本文用甲醇:水(85:15)为流动相在Zorbax-C_(18)色谱柱中分离,以uv200nm检测。所建立的方法简便,灵敏、准确。