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1.
We present the case of a male patient with severe SARS-CoV-2 pneumonia, with simultaneous onset of p-ANCA positive rapidly progressive glomerulonephritis. We discuss the different therapeutic possibilities, emphasising the appropriateness of their administration according to the time in the course of the infection. 相似文献
2.
J. Savige L. Amos Frank Ierino H. G. Mack R. C. Andrew Symons P. Hughes 《Ophthalmic genetics》2016,37(4):369-376
Background: Dense deposit disease and atypical hemolytic uremic syndrome are often caused by Complement Factor H (CFH) mutations. This study describes the retinal abnormalities in dense deposit disease and, for the first time, atypical haemolytic uremic syndrome. It also reviews our understanding of drusen pathogenesis and their relevance for glomerular disease. Methods: Six individuals with dense deposit disease and one with atypical haemolytic uremic syndrome were studied from 2 to 40 years after presentation. Five had renal transplants. All four who had genetic testing had CFH mutations. Individuals underwent ophthalmological review and retinal photography, and in some cases, optical coherence tomography, and further tests of retinal function. Results: All subjects with dense deposit disease had impaired night vision and retinal drusen or whitish-yellow deposits. Retinal atrophy, pigmentation, and hemorrhage were common. In late disease, peripheral vision was restricted, central vision was distorted, and there were scotoma from sub-retinal choroidal neovascular membranes and atypical serous retinopathy. Drusen were present but less prominent in the young person with atypical uremic syndrome due to a heterozygous CFH mutation. Conclusions: Drusen are common in forms of C3 glomerulopathy caused by compound heterozygous or heterozygous CFH mutations. They are useful diagnostically but also impair vision. Drusen have an identical composition to glomerular deposits. They are also identical to the drusen of age-related macular degeneration, and may respond to the same treatments. Individuals with a C3 glomerulopathy should be assessed ophthalmologically at diagnosis, and monitored regularly for vision-threatening complications. 相似文献
3.
目的:探讨增殖性肾小球肾炎大鼠动物模型中系膜细胞α-平滑肌肌动蛋白(α-SMA)表达与细胞表型的关系。方法:应用单克隆抗体1-22-3(MoAb1-22-3)及Habu蛇毒素分别诱导大鼠增殖性肾小球肾炎动物模型。用免疫组化技术并结合计算机图像分析,检测两个不同诱因引起模型的各个阶段的系膜细胞内α-平滑肌肌动蛋白,SMeb的表达程度,系膜细胞增殖和细胞外基质(ECM)分泌的情况。结果:在MoAb1-22-3模型,随着系膜细胞增殖程度的加理,ECM积聚增多,α-SMA的表达程度也增加,三者平行变化并具有高度相关性,而Habu模型则系膜细胞增殖和ECM增加的同时α-SMA,SMemb表达不增加。结论:α-SMA不是系膜细胞被激活并处于增殖/分泌表型唯一标志。 相似文献
4.
李松林副主任医师将肾小球肾炎的病机概括为湿、热、毒、瘀、虚等方面,在中医辨证的基础上,结合现代医学对其病因和发病机理的认识及中草药药理作用,针对不同的病理机制和临床表现,提出清热解毒法,活血化瘀法,调补脾肾法,扶正固本法,并视症有机结合,恰当治疗,疗效显著。 相似文献
5.
Fibrillary glomerulonephritis and immunotactoid glomerulopathy. 总被引:6,自引:0,他引:6
6.
Sibylle von Vietinghoff Wolfgang Schneider Friedrich C Luft Ralph Kettritz 《Nephrology, dialysis, transplantation》2006,21(11):3324-3326
7.
目的:介绍实验性小鼠膜性肾小球肾炎(MGN)的复制方法,并探讨其免疫荧光定量分析在肾小球肾炎研究中的应用价值。方法:制备阳离子化牛血清白蛋白(GBSA)并复制小鼠MGN,对各组小鼠进行电镜及免疫荧光观察,并进行免疫荧光定量研究。结果:电镜、免疫荧光观察均显示病理Ⅰ组(PⅡ组)具有典型的MGN病变,病理Ⅱ组(PⅡ组)病变轻微且不典型。免疫荧光定量研究证实PⅠ、PⅡ组与对照组差异有显著性;PⅠ、PⅡ组间差异无显著性。结论:C—BSA可作为复制小鼠MGN的良好抗原,隔日2mg/只尾静脉注射4w即可复制出稳定的小鼠MGN模型。免疫荧光定量分析不仅能直接而准确地反映MGN病理变化,而且在MGN早期即具有诊断价值。 相似文献
8.
目的 探讨自制苏芪合剂对Ⅲ~Ⅳ级IgA肾病患者的疗效及患者T细胞功能的改善.方法 28例Ⅲ~Ⅳ级IgA肾病患者随机分为两组,对照组:醋酸泼尼松-日1mg,kg,隔日晨起顿服,盐酸苯那普利-日10mg;治疗组:在上述用药的基础上加用自制苏芪合剂.8周后,观察患者缓解率、T细胞功能及不良反应.结果 治疗组患者在缓解率、T细胞功能改善等方面优于对照组,且因糖皮质激素的使用而出现的不良反应少于对照组.结论 苏芪合剂联合治疗Ⅲ~Ⅳ级IgA肾病疗效显著并能有效改善T细胞功能. 相似文献
9.
R S Nanra 《Nephrology, dialysis, transplantation》1992,7(5):384-390
Comprehensive renal function tests were performed in 84 patients with analgesic nephropathy, 33 glomerulonephritis patients matched for creatinine clearance, and 30 control subjects. A system of 1-day renal function tests including urine microscopy, creatinine clearance, phenolsulphonphthalein excretion, urine concentration and acidification, and electrolyte excretion, was used. Patients with analgesic nephropathy were found to have significant sterile pyuria and haematuria, even those with mild renal insufficiency, significantly reduced concentrating ability and a distal acidifying defect, and a tendency to impaired sodium conservation. These function defects are consistent with the primary lesion of renal papillary necrosis in analgesic nephropathy; the detection of these defects have implications in patient management. 相似文献
10.
Ulver DERICI Erdal KAN Dilek ERTOY Turgay ARINSOY Ayse DURSUN Zerrin BICIK Sukru SINDEL 《Nephrology (Carlton, Vic.)》2002,7(3):155-157
SUMMARY: Renal involvement is not uncommon in rheumatoid arthritis (RA). Many RA patients have renal dysfunction either secondary to the drugs used to treat arthritis or because of the chronic inflammation. Renal pathologies have often included amyloidosis, drug-related renal disease and mesangial glomerulonephritis. However, membranoproliferative glomerulonephritis has only been rarely reported. We report a case of rheumatoid arthritis associated with membranoproliferative glomerulonephritis that rapidly progressed to end-stage renal disease. 相似文献